Clinical trials: open to volunteers, in Uganda
Rheumatic Heart Disease in Children
Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children
This study will look at whether children ages 5-8 who take Penicillin V by mouth twice a day are less likely to develop rheumatic heart disease (RHD) over a 3-year period compared to children who do not take the medicine.
- Trial name
- MEERCATS 2 (NCT07798232)
- Testing
- Oral Penicillin V
- Where
- Uganda
- Volunteers
- 9,622 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant
Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis
PRISM-TB is an international, seamless, multicenter, open-label, randomized, controlled, pragmatic, stratified medicine, treatment shortening, multi-arm multi-stage (MAMS), noninferiority Phase 2/3 clinical trial for…
- Conditions
- Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant, Tuberculosis, MDR
- Trial name
- PRISM-TB (NCT06441006)
- Testing
- Bedaquiline, Linezolid, Pretomanid
- Where
- 6 sites in Mongolia, Pakistan and 3 more
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Infectious Disease
An International Observational Study of Adults With Acute Infection
Prospective, longitudinal studies of people with acute infections are essential to understand risk factors, clinical manifestations, pathobiology, and management strategies.
- Trial name
- NCT07069400
- Testing
- No intervention
- Where
- 56 sites in United States, Argentina and 19 more
- Volunteers
- 1,500 people
- Sponsor
- University of Minnesota
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple…
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Infertile Patients, Infertility Drugs
- Trial name
- NCT07771283
- Testing
- Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
- Where
- 3 sites in Uganda, Ukraine
- Volunteers
- 360 people
- Sponsor
- LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro
Rheumatic Heart Disease in Children
Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness
This study will look at how many children develop rheumatic heart disease (RHD) over a 3-year period. The study will include children ages 5 to 8 who do not have RHD at the start and who live in areas where the disease is common.
- Trial name
- MEERCATS 1 (NCT07790302)
- Where
- Uganda
- Volunteers
- 7,500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Meningitis
Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda
This study will investigate the burden, causes, diagnostics, treatments and preventive measures related to meningitis in northern Uganda.
- Trial name
- NCT05496673
- Testing
- Pastorex Latex Agglutination Test, Biofire PCR for meningitis, Immy CrAg Lateral Flow Assay
- Where
- Uganda
- Volunteers
- 11,100 people
- Sponsor
- University of Rochester
Malaria (Plasmodium Falciparum), Malaria Incidence
Insecticide-Treated Baby Wraps for the Prevention of Malaria
The objective is to test the protective effect of permethrin-treated and etofenprox-treated lesus against malaria in young children
- Trial name
- NCT07773350
- Testing
- Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis
A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB)
The A5414 study will evaluate whether treatment for drug-susceptible pulmonary tuberculosis (TB) can be tailored according to a participant's risk of an unfavorable outcome.
- Trial name
- NCT07595042
- Testing
- Isoniazid, Rifampin, Pyrazinamide
- Where
- 29 sites in Argentina, Australia and 14 more
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Schistosomiasis, Schistosoma Mansoni
Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis
The goal of this clinical trial is to learn if treating individuals living in Uganda who have liver fibrosis (scarring) due to schistosomiasis would benefit from more frequent treatment with drug praziquantel.
- Conditions
- Schistosomiasis, Schistosoma Mansoni, Liver Fibrosis, Portal Hypertension
- Trial name
- SchiFT (NCT07754617)
- Testing
- Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year
- Where
- Uganda
- Volunteers
- 600 people
- Sponsor
- Rhode Island Hospital
Sepsis
Call for Life Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-attributable mortality in sub-Saharan Africa (sSA) is high, with in-hospital mortality in some settings approaching 40%.
- Trial name
- C4L-Sepsis (NCT07407868)
- Testing
- Interactive Voice Response system-Call for life IVR
- Where
- 2 sites in Uganda
- Volunteers
- 1,410 people
- Sponsor
- Makerere University
Malaria, PLASMODIUM FALCIPARUM MALARIA
Assessing Vaccine Effectiveness of R21/Matrix-M Across Malaria Transmission Settings (AVERT)
The AVERT study is a prospective observational test-negative case control study evaluating the real-world effectiveness of the R21/Matrix-M malaria vaccine among children younger than 5 years in Burkina Faso and Uganda.
- Trial name
- AVERT (NCT07749911)
- Testing
- R21/Matris-M Malaria vaccine
- Where
- 21 sites in Burkina Faso, Uganda
- Volunteers
- 20,000 people
- Sponsor
- Clinton Health Access Initiative Inc.
Abdominal Neoplasm
KeyScope Study in Uganda
KeyScope and KeyLoop (collectively called KeySuite) are laparoscopic prototypes that the investigators have designed for the resources, needs and challenges of low- and middle- income countries (LMICs).
- Trial name
- NCT06212570
- Testing
- KeySuite
- Where
- Uganda
- Volunteers
- 12 people
- Sponsor
- Duke University
Stroke
Prevention and Rehabilitation of Stroke in Uganda
Stroke is increasing in low-income countries in Africa, and knowledge is lacking on risk factors and how to prevent stroke as well as how to best use the resources for rehabilitation after stroke which are very limited.
- Trial name
- NCT05807269
- Where
- 2 sites in Uganda
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Mental Illness, Suicidal
Disclosure, Social Harm, and Support Activation Study
To characterize how disclosure of suicide or severe emotional distress functions socially in rural eastern Uganda: who people have disclosed to, what happened, what harms resulted, who they would want involved in future support…
- Trial name
- NCT07730307
- Testing
- Survey Questionnaire
- Where
- Uganda
- Volunteers
- 361 people
- Sponsor
- Yale University
Hiv, Cryptococcal Meningitis
Platform Trial For Cryptococcal Meningitis (PLATFORM-CM)
Cryptococcal meningitis is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy.
- Trial name
- PLATFORM-CM (NCT06666322)
- Testing
- Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2
- Where
- 2 sites in Uganda
- Volunteers
- 2,000 people
- Sponsor
- David Boulware
Tuberculosis, Tuberculosis, Pulmonary
Shortened Regimen for Drug-susceptible TB in Children
While drug-susceptible tuberculosis (TB) disease in children currently requires four to six months of treatment, most children may be able to be cured with a shorter treatment of more powerful drugs.
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Tuberculosis, Lymph Node, Mycobacterium Tuberculosis
- Trial name
- SMILE-TB (NCT06253715)
- Testing
- Isoniazid, Rifampin, Pyrazinamide
- Where
- 9 sites in India, Indonesia and 5 more
- Volunteers
- 860 people
- Sponsor
- Johns Hopkins University
Contraception
I-CAN Uganda Effectiveness Trial
This is a cluster-randomized controlled trial to determine the effectiveness of the community-based "I-CAN" intervention to improve agency in contraceptive decision-making and use in rural Uganda.
- Trial name
- I-CAN (NCT07711717)
- Testing
- I-CAN
- Where
- Uganda
- Volunteers
- 1,560 people
- Sponsor
- University of California, San Francisco
Mental Health
Testing Multi-level Scale-Up Strategies: Ugandan School System
The overall objective of the project is to address the school mental health evidence-based interventions (EBIs) scale-up and sustainability challenges in low-and-middle-income countries (LMICs) by studying "system level…
- Trial name
- NCT07466563
- Testing
- Mental Health Evidence-Based Interventions (EBIs)., EBI Support
- Where
- 2 sites in Uganda
- Volunteers
- 1,536 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mental Health Literacy, Depression, Anxiety
Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda
This study record describes a two-phase of clinical trial study. The first phase is a pilot study phase (to study feasibility and efficacy of the intervention), and the second phase is an effectiveness study phase (a fully…
- Trial name
- NCT06087159
- Testing
- mHealth Toolkit for Wellness & Empowering Lives of School Community (mWEL)
- Where
- 2 sites in Uganda
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tuberculosis
Candidate Clinical Correlate of Prognostic Outcome for TB Study
As part of the ongoing efforts within the Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) study, the Candidate Clinical Correlate as Prognostic Outcome for TB (C3PO) study serves as a supplement aimed…
- Trial name
- C3PO (NCT07018076)
- Testing
- RS ratio, Blood-based host immune response assays
- Where
- 3 sites in Uganda, Vietnam
- Volunteers
- 750 people
- Sponsor
- University of California, San Francisco