Clinical trials: completed, in Uganda
Sickle Cell Anemia, Malaria
Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Malaria is fatal and increases the risk of death among children with sickle cell anemia. Chemoprophylaxis significantly improves quality of life in these children.
- Trial name
- NCT00399074
- Testing
- sulfadoxine pyrimethamine
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Makerere University
Malaria, Fever
Training in Fever Case Management With Rapid Diagnostic Tests (RDTs) for Malaria in Uganda
Malaria remains one of the most devastating infectious diseases in the world. Despite the potential for serious adverse outcomes with each episode of malaria, most cases in endemic areas are diagnosed on clinical grounds alone.
- Trial name
- NCT00716599
- Testing
- training in use of rapid diagnostic tests (RDTs) for malaria
- Where
- Uganda
- Volunteers
- 14,000 people
- Sponsor
- University of California, San Francisco
HIV Infections
Effect of Multiple Micronutrient Supplementation on Growth, Morbidity, and Mortality of HIV Infected Children in Uganda
Micronutrient deficiencies are common in HIV infected children and are aggravated by poor nutrition, especially in poor resource countries such as Uganda.
- Trial name
- MMS (NCT00122941)
- Testing
- multiple micronutrients
- Where
- 2 sites in Norway, Uganda
- Volunteers
- 860 people
- Sponsor
- Makerere University
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Schistosomiasis, Malaria
The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda
The overall objective of the project is to contribute to an increased knowledge about the effect of praziquantel on schistosomiasis related morbidity and re-infection level among communities living along Lake Victoria in Mayuge…
- Trial name
- NCT00215267
- Testing
- praziquantel
- Where
- Uganda
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
HIV Infections
Comparison of Plasma Drug Levels of Triomune 40 With Those of the Originator Products
This study aims to compare the steady state pharmacokinetics of stavudine, lamivudine, and nevirapine in HIV positive Ugandan patients taking Triomune 40 with the pharmacokinetics of the originator products known as Viramune…
- Trial name
- NCT00455585
- Testing
- nevirapine, stavudine, lamivudine
- Where
- Uganda
- Volunteers
- 18 people
- Sponsor
- Makerere University
Schistosomiasis, Helminthiasis
Schistosomiasis in Formal and Non-Formal Schools in Uganda: Implications for Control Programmes
Current efforts to control schistosomiasis and soil-transmitted helminthes infections focus on the school-age population, and school-based treatment delivery programs offer a major cost advantages because of the use of the…
- Conditions
- Schistosomiasis, Helminthiasis, Anaemia
- Trial name
- NCT00463593
- Where
- Uganda
- Volunteers
- 1,293 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Posttraumatic Stress Disorder
Treatment of Posttraumatic Stress Disorder by Trained Lay Counsellors in an African Refugee Settlement
The study is a pragmatic trial to study the efficacy of two active methods of psychotherapy for the treatment of posttraumatic stress disorder in a refugee camp in Africa. Treatment was administered by lay counsellors.
- Trial name
- NCT00550056
- Testing
- Narrative Exposure Therapy, Trauma Counselling
- Where
- Uganda
- Volunteers
- 277 people
- Sponsor
- University of Konstanz
Tuberculosis, HIV Infections
Tuberculosis in HIV Infected Patients in Uganda
This was a clinical trial in HIV infected patients with tuberculosis. The study assessed whether the addition of prednisolone, a type of steroid medication, to the standard treatment for tuberculosis improved immune and viral…
- Trial name
- NCT00057421
- Testing
- prednisolone
- Where
- Uganda
- Volunteers
- 190 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Herpesvirus 2, Human
Male Circumcision for HIV Prevention in Rakai, Uganda
Circumcision in HIV unifected men may reduce the likelihood of becoming infected with HIV, reduce sexually transmitted infections (STIs) in men, not engender increases in sexual risk behaviors, and be acceptable to men as a…
- Conditions
- HIV Infections, Herpesvirus 2, Human, Syphilis, Genital Diseases, Male
- Trial name
- NCT00425984
- Testing
- Adult male circumcision
- Where
- Uganda
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mansonelliasis, Pruritus
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available.
- Conditions
- Mansonelliasis, Pruritus, Lymphoedema, Abdominal Pains
- Trial name
- NCT00215280
- Testing
- ivermectin and albendazole
- Where
- Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Tuberculosis, Pulmonary
TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment
This study is a placebo-controlled factorial study, randomized to study drug (moxifloxacin vs. ethambutol) and treatment frequency (daily vs.
- Trial name
- NCT00140309
- Testing
- moxifloxacin (with isoniazid, rifampin, pyrazinamide)
- Where
- 23 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Centers for Disease Control and Prevention
Infections, Meningococcal, Meningitis, Meningococcic
Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine
Hypothesis: Lower doses of each A/C/Y/W135 component of the meningococcal polysaccharide vaccine could confer a similar functional immunogenic response as the dose of 50 μg currently being used, and subsequently be equally…
- Trial name
- NCT00271479
- Testing
- A, C, Y, W135 meningococcal polysaccharide vaccine
- Where
- 2 sites in Norway, Uganda
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Epicentre
Low Weight for Age in Preschool Children
Effect of Mass Deworming on Child Growth
The purpose of the study was to determine whether periodical mass deworming improves growth in children below six years of age.
- Trial name
- NCT00344669
- Testing
- Albendazole 400 mg, given 6 monthly
- Where
- Uganda
- Volunteers
- 10,000 people
- Sponsor
- Makerere University