Clinical trials: open to volunteers, in United Kingdom
Hepatocellular Carcinoma, Cholangiocarcinoma
Deep Liver Phenotyping and Immunology Study
Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the two most common causes of primary liver cancer and HCC is the second highest cause of cancer death worldwide.
- Trial name
- DELPHI (NCT04946773)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Oxford
Warm Antibody Autoimmune Hemolytic Anemia
A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia
The primary objective of this study is: To evaluate the long-term safety of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia (wAIHA).
- Trial name
- NCT04138927
- Testing
- Fostamatinib disodium
- Where
- 37 sites in United States, Australia and 16 more
- Volunteers
- 90 people
- Sponsor
- Rigel Pharmaceuticals
Glioma
Mapping Molecular Markers of Brain Tumour Activity Using MRI
Regions of tumour whose cells (the building blocks of the tumour) are actively multiplying generate a particular type of molecular footprint (consisting of various types of proteins) compared to tumours whose cells are relatively…
- Trial name
- NCT05140785
- Testing
- Advanced MRI sequences
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Non-Alcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver
European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)
The EU-PNAFLD (The European Paediatric NALFD Registry) will be a network composed of European centres involved in the care of children with NAFLD, and will include Hepatologists, Endocrinologists, and Scientists, supported by…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver, Non-alcoholic Steatohepatitis
- Trial name
- EU-PNAFLD (NCT04190849)
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Polycystic Ovary Syndrome
Reproductive Endocrinology Oxford Study (RepOx)
This is a prospective observational study that aims to identify the underlying mechanisms of PolyCystic Ovarian Syndrome (PCOS) and associated comorbidities such as subfertility, miscarriage; and pregnancy complications such as…
- Trial name
- RepOx (NCT05177562)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 1,175 people
- Sponsor
- University of Oxford
Magnetic Resonance Imaging
Evaluation of New Magnetic Resonance Techniques
The aim of this research protocol is to undertake evaluation of new and emerging MR techniques in patients and healthy volunteers following software or hardware upgrades, as well as for newly developed MR techniques; to establish…
- Trial name
- NCT05118555
- Where
- United Kingdom
- Volunteers
- 2,850 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Rectal Cancer
Robotic vs. TaTME Rectal Surgery (ROTA STUDY)
Background Recent novel surgical techniques for resection of low rectal cancer have been introduced and these approaches have the potential to overcome anatomical limitations like obesity, narrow male pelvis and bulky and low…
- Trial name
- ROTA (NCT04200027)
- Testing
- total mesorectal excision
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital
Cancer
Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
The Hamlet.rt study is a prospective data collection and patient questionnaire study for patients undergoing image-guided radiotherapy with curative intent.
- Trial name
- Hamlet rt (NCT04060706)
- Testing
- Radical Image-Guided Radiotherapy
- Where
- United Kingdom
- Volunteers
- 310 people
- Sponsor
- CCTU- Cancer Theme
Mitral Regurgitation
Tendyne European Experience Registry
TENDER is a multicenter, single-device, retrospective and prospective, observational study to assess safety and efficacy of the Tendyne Mitral Valve System in a real-world population.
- Trial name
- TENDER (NCT04898335)
- Testing
- Tendyne Mitral Valve System
- Where
- 30 sites in Austria, Belgium and 8 more
- Volunteers
- 400 people
- Sponsor
- LMU Klinikum
Obesity, Type 2 Diabetes
Gut Hormones and Roux en Y Gastric Bypass
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.
- Trial name
- NCT01945840
- Testing
- Roux en Y Gastric Bypass Surgery, Gut hormone infusion, Very low calorie diet
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetic Kidney Disease
Prognostic Imaging Biomarkers for Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a common complication of diabetes, and is now the most common form of chronic kidney disease. DKD is the leading cause of kidney disease requiring dialysis or kidney transplantation, and its…
- Trial name
- iBEAt (NCT03716401)
- Testing
- MRI (magnetic resonance imaging), US (ultrasound), Renal Biopsy
- Where
- 7 sites in Finland, France and 4 more
- Volunteers
- 500 people
- Sponsor
- University of Leeds
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Renal Cell Carcinoma
Renal Adjuvant MultiPle Arm Randomised Trial
RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means).
- Trial name
- RAMPART (NCT03288532)
- Testing
- Durvalumab, Tremelimumab
- Where
- 35 sites in United Kingdom
- Volunteers
- 1,750 people
- Sponsor
- University College, London
Melanoma
Serial Tumour Biopsies and Blood Biomarkers in Melanoma
Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma.
- Trial name
- NCT04493723
- Testing
- Surgery, Venepuncture
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- The Christie NHS Foundation Trust
Acute Coronary Syndrome
The Harefield Acute Myocardial Infarction Cohort
In this project the investigator's plan to collect blood during a patient's routine angiogram procedure which they will have due to having suffered a heart attack.
- Trial name
- HEART - ACS (NCT04218344)
- Testing
- 60mls of blood donated for research analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Parkinson's Disease, Parkinsonism
Parkinson's Families Project
One person in every 500 has Parkinson's and around 127,000 people are living with the condition in the UK. The aim of the study is to identify new genes that predispose or cause Parkinson's Disease or Parkinsonism.
- Trial name
- PFP (NCT02760108)
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Endometriosis Rectovaginal Septum
Laparoscopic Surgery for Severe Recto-vaginal Endometriosis
To determine the quality of life following the radical excision of recto-vaginal endometriosis.
- Trial name
- NCT02471443
- Testing
- Surgery for severe endometriosis
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Retroperitoneal Sarcoma
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a…
- Trial name
- RESAR (NCT03838718)
- Where
- 22 sites in United States, Australia and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Multiple Myeloma
The Role of Ixazomib in Autologous Stem Cell Transplant in Relapsed Myeloma - Myeloma XII (ACCoRd)
Study design: Randomised, controlled, multi-centre, open-label, phase III trial (with a single intervention registration phase).
- Trial name
- NCT03562169
- Testing
- Ixazomib, thalidomide, & dexamethasone (ITD) re-induction, Conventional autologous stem cell transplant (ASCT-con), Augmented autologous stem cell transplant (ASCT-aug)
- Where
- 91 sites in United Kingdom
- Volunteers
- 406 people
- Sponsor
- University of Leeds