Clinical trials: in Venezuela
Device Related Infection, Device Malfunction
Project My Heart Your Heart: Pacemaker Reuse
Lack of access to pacemakers is a major challenge to the provision of cardiovascular health care in Low and Middle Income Countries (LMIC).
- Conditions
- Device Related Infection, Device Malfunction, Bradycardia
- Trial name
- MHYH (NCT04016870)
- Testing
- Reconditioned Pacemaker, New Pacemaker
- Where
- 8 sites in Kenya, Mexico and 5 more
- Volunteers
- 370 people
- Sponsor
- University of Michigan
Heart Failure, Acute Heart Failure (AHF)
American Registry of Ambulatory or Acutely Decompensated Heart Failure
The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and…
- Conditions
- Heart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
- Trial name
- AMERICCAASS (NCT05295641)
- Where
- 119 sites in United States, Argentina and 19 more
- Volunteers
- 6,732 people
- Sponsor
- Fundacion Clinica Valle del Lili
Infertility, Female, Reproductive Techniques, Assisted
Use of Autologous Exosomes vs Platelet Growth Factors to Regenerate the Ovary in Women With Infertility (Exosomas2024-1)
Ovarian stromal fibrosis resulting from each ovulation and due to aging is characterized by a decrease in hyaluronic acid concentrations, loss of synthesis and migration proteins CD63 and CD81, decreased miRNA125, miRNA21…
- Trial name
- Exosom2024-1 (NCT06773572)
- Testing
- Autologous Exososomes procedure obtained from the patients' own platelets., Patient group for activated platelet growth factors, the control group
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biotech Fertility C.A.
Non Small Cell Lung Cancer, Lung Cancer
Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients
Non-small cell lung cancer (NSCLC) can be treated with drugs that kill tumour cells, stop them from dividing, or stop the growth of the blood supply that cancers need to grow and spread.
- Trial name
- ZEAL (NCT00418886)
- Testing
- Vandetanib, Pemetrexed
- Where
- 110 sites in United States, Argentina and 19 more
- Volunteers
- 698 people
- Sponsor
- Genzyme, a Sanofi Company
Acute Malnutrition in Childhood, Wasting
Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort Research
The goal of this observational study is to compare the effectiveness, safety, and efficiency of the simplified protocol, which includes the following three modifications: a) use of a single treatment product (RUTF), b) reduced…
- Conditions
- Acute Malnutrition in Childhood, Wasting, Child Malnutrition
- Trial name
- NCT06287827
- Testing
- Simplified protocol, Standard protocol
- Where
- 4 sites in Venezuela
- Volunteers
- 299 people
- Sponsor
- UNICEF - Venezuela
Fractures or Dislocations
INternational ORthopaedic MUlticenter Study in Fracture Care (INORMUS)
Background: Worldwide, injuries from trauma represent a major public health problem. The World Health Organization (WHO) has deemed this problem as one of the most important global priorities, calling 2011-2020 the 'Decade of…
- Trial name
- INORMUS (NCT02150980)
- Where
- 69 sites in Argentina, Botswana and 24 more
- Volunteers
- 39,797 people
- Sponsor
- McMaster University
Hemorrhoids, Defecation Disorder
Efficacy of Stapled Hemorrhoidopexy for the Treatment of Obstructive Defecation Syndrome
The objective of this study is to assess the efficiency of the procedure for hemorrhoidal prolapse and pexia in alleviating symptoms of defecatory obstruction among patients with grade II to IV mucohemorrhoidal prolapse.
- Trial name
- NCT06294470
- Testing
- Ballon expulsion test, Colonic transit time, Stapled hemorrhodopexy
- Where
- Venezuela
- Volunteers
- 34 people
- Sponsor
- Universidad Central de Venezuela
Aortic Stenosis
transShield Embolic Protection System Feasibility Study
The objective of this study is to evaluate the safety and performance of the transShield Embolic Protection System (EPS) used for embolic protection during Transcatheter Aortic Valve Replacement (TAVR).
- Trial name
- NCT04585308
- Testing
- transShield Embolic Protection System
- Where
- 4 sites in New Zealand, Venezuela
- Volunteers
- 28 people
- Sponsor
- TransAortic Medical, Inc.
Pseudoarthrosis of Bone, Pseudarthrosis
Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)
The goal of this study is to evaluate the bone regeneration capacity of BM-MSC (Bone marrow mesenchymal stromal cells), in patients with nonunion.
- Conditions
- Pseudoarthrosis of Bone, Pseudarthrosis, Non Union Fracture, Nonunion Bone Fracture
- Trial name
- MSC (NCT06103396)
- Testing
- Transplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture
- Where
- Venezuela
- Volunteers
- 30 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Burn Wound, Second- or Third-degree Burn
MSCs for the Treatment of Burn Wounds
The goal of this study is to evaluate the capacity of allogenic mesenchymal stromal cells form bone marrow (BM-MSC) or adipose tissue(Ad-MSC) to induce wound healing in patients with burn wounds.
- Trial name
- NCT06103409
- Testing
- Implantation of allogeneic MSCs on burn wounds
- Where
- Venezuela
- Volunteers
- 50 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Metastatic Breast Cancer
A Phase 1b/2 Clinical Trial to Evaluate the Safety and Efficacy of ConvitVax in Metastatic Breast Cancer
This is a proof-of-concept, single-center, non-randomized, open-label, phase 1b/2 study to evaluate the safety and efficacy of ConvitVax, a simple, low cost (of manufacture), personalized, potentially safe and effective breast…
- Trial name
- NCT06023277
- Testing
- ConvitVax
- Where
- 3 sites in United States, Venezuela
- Volunteers
- 40 people
- Sponsor
- Jacinto Convit World Organization Inc.
Chronic Periodontal Disease, Aggressive Periodontitis
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration
The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease.
- Trial name
- BMMSC (NCT05975892)
- Testing
- Transplantation of allogeneic MSCs in periodontal disease
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Breast Cancer, Neoplasm Metastasis
Vinorelbine Versus Gemcitabine Plus Vinorelbine in Metastatic Breast Cancer Patients
This is a multicenter, randomized, prospective, Phase III study in which patients with advanced breast carcinoma previously treated with anthracyclines and taxanes will be randomly assigned to receive one of two treatment…
- Trial name
- NCT00128310
- Testing
- Vinorelbine, Gemcitabine
- Where
- 2 sites in Spain, Venezuela
- Volunteers
- 252 people
- Sponsor
- Spanish Breast Cancer Research Group
Acute Malnutrition in Childhood, Wasting
Simplified Treatment Protocol for Acute Malnutrition in Venezuela
Global acute malnutrition (GAM) in children under five is defined by being too thin for a given height and/or having the Mid-upper arm circumference less than a given threshold.
- Conditions
- Acute Malnutrition in Childhood, Wasting, Child Malnutrition
- Trial name
- NCT05543759
- Testing
- Ready-To-Use Therapeutic Food (RUTF)
- Where
- Venezuela
- Volunteers
- 307 people
- Sponsor
- UNICEF - Venezuela
Bariatric Surgery Candidate, GERD
9-Step Magnetic Bariatric Revisional Surgery
RYGB represents one of the best alternatives for weight loss in obese patients achieving a weight loss of up to 60% and a resolution of comorbidities of 70%.
- Conditions
- Bariatric Surgery Candidate, GERD, Revisional Bariatric Surgery
- Trial name
- NCT04945304
- Testing
- magnetic bariatric surgery, Magnetic gastric bypass
- Where
- Venezuela
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unidad Internacional de Cirugia Bariatrica y Metabolica
COVID-19, COVID-19 Pneumonia
Study to Verify the Effectiveness and Safety of Isothymol or Carvacrol Compound Against SARS-CoV-2 in COVID-19 Patients
Check the efficacy, safety and tolerability of the compound Modified isothymol against the SARS-CoV-2 agent in patients COVID-19.
- Conditions
- COVID-19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05445089
- Testing
- Carvacrol, Control group
- Where
- Venezuela
- Volunteers
- 600 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Surgery, Bariatric Surgery Candidate
Magnetic System in Bariatric and General Surgery
Magnetic devices have been successfully used in bariatric surgery. To the date the only reported use of the magnet was for liver retraction.
- Trial name
- NCT04944810
- Testing
- Magnetic Gastric Bypass, Magnetic Sleeve Gastrectomy, Revisional Bariatric Surgery
- Where
- Venezuela
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Unidad Internacional de Cirugia Bariatrica y Metabolica
Zika Virus, Pregnancy Related
ZIKAlliance Pregnant Women Cohort
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAlliancePW (NCT03188731)
- Where
- 14 sites in Bolivia, Brazil and 5 more
- Volunteers
- 3,852 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Colonic Diverticula
Predictive Value of DICA in the Diverticular Disease of the Colon
The Diverticular Inflammation and Complication Assessment (DICA) is an endoscopic classification for diverticulosis and diverticular disease of the colon.
- Trial name
- NCT02758860
- Testing
- Colonoscopy
- Where
- 45 sites in Brazil, Italy and 5 more
- Volunteers
- 2,215 people
- Sponsor
- University of Roma La Sapienza
Zika Virus
ZIKAlliance Children Cohort (ZIKAllianceCH)
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAllianceCH (NCT03393286)
- Where
- 10 sites in Bolivia, Brazil and 5 more
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center