Clinical trials: Decitabine
- Drug or intervention Decitabine
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Healthy
To Study the Oral Bioavailability of a New Combination Formation of Decitabine and Tetrahydrouridine in Healthy Males
This is an open-label, randomized, single-dose per period, two-period, crossover study to evaluate the relative bioavailability of decitabine and tetrahydrouridine ingested as a modified-release combination formulation compared…
- Trial name
- NCT05816356
- Testing
- Decitabine, Tetrahydrouridine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.
Healthy
Effect of Food on the Pharmacokinetics of Decitabine/Tetrahydrouridine Combination Capsules in Healthy Adult Subjects
This study is to investigate the effect of a high fat meal on the pharmacokinetics of decitabine and THU in healthy adults when administered as a modified release formulation of the 2 drugs in combination.
- Trial name
- NCT04086238
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.
Healthy Volunteers
A Study to Test How Either a Capsule or a Tablet With NDec (Decitabine and Tetrahydrouridine) Works in the Body of Healthy People
This study will look at two different oral formulations and compare them. The medicine in the study is called NDec and it is a combination of two medicines (decitabine and tetrahydrouridine).
- Trial name
- NCT06291285
- Testing
- Decitabine-THU
- Where
- 2 sites in United States, Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy
Randomized, Single-dose, Crossover Study of 4 Decitabine and Tetrahydrouridine (EPI01) Formulations in Healthy Subjects
To study the pharmacokinetic profiles of decitabine and tetrahydrouridine (THU) from 3 modified release formulations in healthy subjects.
- Trial name
- EPI01 (NCT03828084)
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.