Clinical trials: sponsored by Institut Pasteur
- Sponsor Institut Pasteur
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Lassa Fever
A Trial to Evaluate the Safety, Immunogenicity and the Optimal Dose of MOPEVAC-Las Vaccine Candidate Against Lassa Fever
Lassa fever is an acute viral disease belonging to the category of viral hemorrhagic fevers. It is endemic in West Africa. Outbreaks occur every year, and it is estimated that between 100 000 and 300 000 individuals are infected…
- Trial name
- FIRST-IN-MOP (NCT07833436)
- Testing
- Low dose MOPEVAC-Las vaccine, Intermediate dose MOPEVAC-Las vaccine, High dose MOPEVAC-Las vaccine
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Hearing Disorders and Deafness
Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
- Trial name
- SEQUOIA (NCT07740070)
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Auditory Perception
Sound Perception Study of Hearing-impaired People With Hearing Aids
The aim of the ETERNEL project will be to study the influence of the perception of a single sound timbre on the understanding of a complex sound scene in hearing-impaired people with hearing aids.
- Trial name
- ETERNEL (NCT06691087)
- Testing
- Influence of the parameters of the sound timbre on the perception of a sound, Complex sound scene comprehension test, Complex sound scene comprehension test with hearing aids
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Diabetes Mellitus, Type 2, Obesity
Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia - MIND
In recent years, the global rise in obesity and type 2 diabetes has become a major public health issue. In New Caledonia, 38% of the adult population has a body mass index ≥30.
- Trial name
- MIND (NCT07205913)
- Testing
- 25 ml blood sample, Urine sample, Stools
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Diarrhea, Infantile
Study on the Association Between Vitamin C Deficiency and Diarrhea in Children
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses…
- Trial name
- VITAL (NCT05328037)
- Testing
- Blood sample collection
- Where
- 3 sites in Central African Republic, France and 1 more
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Multiplex Testing of HIV, HBV, HCV and Syphilis, HIV
Clinical Performance Evaluation of MagIA IVD-MD Multiplex Testing (HIV/HBV/HCV/Syphilis)
Performance study to evaluate the clinical performance of the In-Vitro Diagnostics Medical Device MagIA H3S (a Multiplex Point-of-Care test for the combined detection of Human Immunodeficiency Virus (HIV), Hepatitis B and C and…
- Conditions
- Multiplex Testing of HIV, HBV, HCV and Syphilis, HIV, HBV, HCV
- Trial name
- MAGICS IBCS (NCT07170748)
- Where
- 2 sites in Côte d’Ivoire, Kenya
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- MagIA Diagnostics
Skin Immunity
Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)
Sex hormones are major regulators of skin immunity. Pregnancy represents a unique physiological state of profound hormonal remodeling.
- Trial name
- SIAP (NCT07291193)
- Testing
- Blood sample, skin microbiota and biopsy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Breastmilk Collection
Impact of Breast Milk on the Infectivity and Transmission of Different Viruses "BREASTMILKVIR"
Exclusive breastfeeding during the first six months of life and continued breastfeeding for at least 24 months constitute the optimal feeding method for infants and young children.
- Trial name
- BREASTMILKVIR (NCT06738563)
- Testing
- Collection breast milk
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Yellow Fever Vaccine
VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Pregnancy- Yellow Fever)
The aim of this study is to compare the immunogenicity induced by yellow fever vaccination administered during pregnancy with that induced by vaccination outside pregnancy, and to assess the maternal and fetal tolerance of this…
- Trial name
- VAC-SIP-YF (NCT06694766)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Coronavirus Infection, Severe Acute Respiratory Syndrome
Study of the Pathogenesis of Olfactory Disorders in COVID-19
This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.
- Conditions
- Coronavirus Infection, Severe Acute Respiratory Syndrome, Sars-CoV2
- Trial name
- COVIDSMELL (NCT04366934)
- Testing
- Nasal swab, Taste and olfactory function evaluation
- Where
- 2 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Simian Foamy Virus Infection (Disorder)
Simian Foamy Virus Transmission to Humans
About three quarters of the viral agents that have emerged recently in humans are considered to originate from other animals. These viruses have often evolved and spread into the human population through various mechanisms after…
- Trial name
- NCT03225794
- Testing
- Simian foamy virus Infection
- Where
- Cameroon
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Listeriosis
Genetic Susceptibility to Listeriosis
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or…
- Trial name
- Listeria-GEN (NCT03357536)
- Testing
- Human biological samples
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Immunization, Infections
Description of the Immune Response to Yellow Fever Vaccination
Vaccine protection depends on a specific adaptive immune memory. However, a little-explored aspect of certain live vaccines may provide beneficial, non-specific protection against infections or pathogens other than the one from…
- Trial name
- IVORY2 (NCT06718127)
- Testing
- blood samples collection
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Gastric Lesion, Gastric Precancerous Condition
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer
The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control…
- Conditions
- Gastric Lesion, Gastric Precancerous Condition, Gastric Cancer
- Trial name
- PREGASIGN#1 (NCT05854368)
- Testing
- Additional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care., Blood collection
- Where
- 8 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
COVID-19
Understanding the Determinants of Mucosal Immunity and Optimizing the Diagnosis of Infection With SARS-CoV-2 Variants
One of the current health challenges in the face of the COVID-19 pandemic that started in Wuhan in 2019, and still responsible for successive waves, is to better understand and diagnose the infection.
- Trial name
- COVARIANT (NCT05858502)
- Testing
- Blood sample collection, Saliva sample collection, Nasopharyngeal and nasal sample collection
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Travel-Related Illness
Observational Study of Travellers Pathologies
Traveling to emerging countries is associated with a significant risk of encountering health issues specific to the destination, such as gastrointestinal and respiratory infections, malaria episodes, and road traffic…
- Trial name
- EOP (NCT06701890)
- Testing
- Blood sample collection, Fecal sample collection
- Where
- France
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Leptospirosis
Characterizing the Host Response to Leptospirosis for Better Diagnosis and Prognosis - NIHFI
Leptospirosis is a zoonosis found worldwide, but particularly in humid subtropical and tropical zones. It is caused by pathogenic bacteria of the Leptospira species of the spirochete family.
- Trial name
- NIHFI (NCT06945822)
- Testing
- Blood sample, Urine Sample
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Tinnitus
Exploring the Links Between Hearing, Cognition and Brain Activity in People With Tinnitus
The goal of this observational study is to understand the mechanisms underlying tinnitus, and improve the clinical assessment strategies needed to develop targeted therapeutic interventions by comparing endogenous attention…
- Trial name
- GHOSTTONE (NCT06940726)
- Testing
- Quality of Life questionnaires, Hearing tests, Auditory prediction task
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Misophonia
Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia
The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.
- Trial name
- PROMISE (NCT06921187)
- Testing
- Psychoacoustic test, semi-structured interviews, Exposure to unpleasant sounds
- Where
- 2 sites in France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Speech
Elicitation of Steady-state Audiovisual Responses in 6- and 10-month-old Infants
The goal of this study is to investigate the preferential responses of speech neural systems in infants. The main question it aims to answer is to determine whether the oscillatory synchronization capacity is associated with…
- Trial name
- AV-SSR-I (NCT06282289)
- Testing
- Magnetoencephalography (MEG), Cognition development questionnaire
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur