Clinical trials: Conventional therapy
Crohn's Disease
Remicade Safety Line (Crohn's Disease)(Study P03288)(COMPLETED)
This observational study is in line with the German educational plan with the aim to implement a tool to increase and monitor the awareness for tuberculosis screening and to reinforce the patient eligibility for a treatment with…
- Trial name
- NCT00818272
- Testing
- Remicade (infliximab)
- Volunteers
- 148 people
- Sponsor
- Merck Sharp & Dohme LLC
Advance Malignancies
Safety, Tolerability & PK of KX2-361 in Subjects w Adv. Malignancies Refractory to Conventional Therapies
The purpose of this study is to determine the safety and tolerability of the study drug KX2-361 and to determine how much of the study drug enters the bloodstream, in patients with advanced malignancies that have not responded to…
- Trial name
- NCT02326441
- Testing
- KX2-361
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Athenex, Inc.
Chronic Low-back Pain
Digital Care Program for Chronic Low Back Pain
New ways of delivering care are much needed to address chronic low back pain. Crucially, these need to: a) address the three pillars of care to achieve good and sustained clinical outcomes; b) overcome barriers to access; c)…
- Trial name
- NCT04808141
- Testing
- Digital program, Conventional physical therapy
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Sword Health, SA
Pancreatic Ductal Adenocarcinoma
Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancer
In order to improve the survival rates and decrease progression of pancreatic advanced cancer, this study aims to evaluate the first line treatment approved for this disease (gemcitabine plus nab-paclitaxel) in combination with…
- Trial name
- NUMANTIA (NCT04827953)
- Testing
- Gemcitabine, Nab paclitaxel, NLM-001
- Where
- 6 sites in Spain
- Volunteers
- 28 people
- Sponsor
- Nelum Corp
Macular Degeneration
Visudyne® in Occult (VIO)
The purpose of this study is to demonstrate that Visudyne therapy in patients who have occult with no classic subfoveal choroidal neovascularization (CNV) lesions will, with an acceptable safety profile, significantly reduce the…
- Trial name
- NCT00121407
- Testing
- Visudyne for injection
- Volunteers
- 364 people
- Sponsor
- QLT Inc.
Neoplasms, Solid Tumors
A Trial Of SU14813 In Patients With Advanced Solid Malignancies
The purpose of this study is to define the Maximum tolerated dose of SU14813 when administered as single agent in patients with solid tumors.
- Trial name
- NCT00982267
- Testing
- SU014813
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 77 people
- Sponsor
- Pfizer
Foot Ulcers, Diabetic
Efficacy of Plasma Rich in Growth Factors (PRGF) in the Treatment of Foot Ulcers in Diabetic Patients With Peripheral Arterial Disease
This study is a randomized clinical trial that compares the effectiveness of Plasma Rich in Growth Factors (PRGF) with conventional treatment for healing foot ulcers in diabetic patients who also have peripheral arterial disease.
- Trial name
- PIEDIABETICO (NCT06952998)
- Testing
- Topical application of Plasma Rich in Growth Factors (PRGF), Conventional treatment (conventional treatment with adequate offloading and metabolic control, +/- antibiotic).
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Biotechnology Institute IMASD
Hepatitis B, Chronic
Tolerability, Immunogenicity and Efficacy of HB-110 Administered by Electroporation in Chronic Hepatitis B Patients
This study is an open label, dose escalation study using the classical 3+3 design to determine the MTD of HB-110 and assess the safety, immunogenicity and efficacy of HB-110 DNA therapeutic vaccine administered by Electroporation…
- Trial name
- NCT01641536
- Testing
- HB-110
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Genexine, Inc.
Classic Hodgkin Lymphoma
A Study of AK129 With or Without AK117 in PD(L)1-refractory Classic Hodgkin Lymphoma
This is a phase I/II study. All subjects are patients diagnosed with relapse or refractory (R/R) classic Hodgkin lymphoma (cHL) and has progressed on treatment with PD-1/L1 inhibitor therapy.
- Trial name
- NCT06642792
- Testing
- AK129, AK117
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Akeso
Stroke
"Evaluation Of ALBA® Device for Upper Extremity Motor Function In Adults With Subacute And Chronic Acquired Brain Injury"
As part of the rehabilitation techniques, robotic equipment has been introduced for the rehabilitation of the upper extremity with promising results.
- Trial name
- NCT05824416
- Testing
- Experimental: ALBA, Conventional Therapy
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- uMov
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction
This study aims to evaluate the value of Shexiang Baoxin Pill (MUSKARDIA) in patients with acute myocardial infarction (AMI) through a prospective, multicenter, pragmatic randomized controlled real-world study.
- Trial name
- MUST Ⅱ (NCT07153744)
- Testing
- Aspirin, Shexiang Baoxin Pill
- Where
- China
- Volunteers
- 9,588 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Dyspnea, Hypercapnia
Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] next generation nasal cannula designs to effect ventilation and related physiological responses relative to the conventional legacy cannula design.
- Conditions
- Dyspnea, Hypercapnia, Respiratory Insufficiency
- Trial name
- NCT04512781
- Testing
- Control Cannula - Prosoft Cannula - Unicorn Cannula, Control Cannula - Unicorn Cannula - Prosoft Cannula
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Vapotherm, Inc.
Ulcerative Colitis
A Study of Ozanimod in Pregnant Women With Ulcerative Colitis and Their Offspring
The purpose of this study is to evaluate association between ozanimod exposure during pregnancy and subsequent maternal, fetal, and infant outcomes.
- Trial name
- NCT05953402
- Where
- United States
- Volunteers
- 1,182 people
- Sponsor
- Bristol-Myers Squibb
Health Services Administration, Telemedicine
The Impact of Telemonitoring in the Management of Hypertension
Rater blinded, multi-center, prospective, randomized controlled study comparing mean 24 hour systolic blood pressure of eligible hypertensive patients in the TELEMONITORIN group versus the USUAL CARE group, at 6 months after…
- Conditions
- Health Services Administration, Telemedicine, Hypertension
- Trial name
- HOROSCOPE (NCT04607239)
- Testing
- Telemonitoring, Usual Care without Telemonitoring
- Where
- Tunisia
- Volunteers
- 460 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Rheumatoid Arthritis
Retrospective Evaluation of the Radiographic Efficacy of Conventional and Biologic Treatment
This study involves review and analysis of disease activity in patients with rheumatoid arthritis who where treated with either conventional DMARDs (Disease Modifying Antirheumatic Drugs) or Biologics and have two existing…
- Trial name
- NCT00929357
- Testing
- DMARDs or Biologics
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Pfizer
Schizophrenia
Rapid Dose Escalation of Quetiapine Versus Conventional Escalation in Acute Schizophrenic Patients
The purpose of the study is to compare the safety and tolerability of IR (Immediate-Release) quetiapine in a rapid escalation scheme with to the current approved label titration.
- Trial name
- NCT00254787
- Testing
- IR (Immediate-Release) quetiapine fumarate (drug)
- Where
- 6 sites in Germany
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Asthma, Bronchial
Symbicort Single Inhaler Therapy vs Conventional Best Practice for the Treatment of Persistent Asthma in Adults
This study is intended to extend the knowledge of Symbicort Single Inhaler Therapy into a more general setting in order to assess the real-life impact of introducing this new treatment concept.
- Trial name
- NCT00385593
- Testing
- Symbicort (budesonide/formoterol) Turbuhaler, Conventional treatment
- Where
- 52 sites in Spain
- Volunteers
- 654 people
- Sponsor
- AstraZeneca
Retinopathy of Prematurity
Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients With Retinopathy of Prematurity
The primary objective of the study is to assess the efficacy of aflibercept compared to laser in patients diagnosed with retinopathy of prematurity (ROP).
- Trial name
- BUTTERFLEYE (NCT04101721)
- Testing
- aflibercept, laser photocoagulation
- Where
- 52 sites in United States, Bulgaria and 11 more
- Volunteers
- 127 people
- Sponsor
- Regeneron Pharmaceuticals
Dialysis Amyloidosis
Post Approval Study of Lixelle for the Treament of Dialysis-Related Amyloidosis
Dialysis-related amyloidosis (DRA) is a serious complication of long-term hemodialysis (HD). Its pathogenic mechanism involves accumulation of β2-microglobulin (β2M) in the blood.
- Trial name
- NCT02952144
- Testing
- Lixelle® treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kaneka Medical America LLC
Dental Caries
Survival Rate and Cost-effectiveness of Conventional vs ART Restorations in a School Setting
This study will investigate the performance and cost-effectiveness of glass-ionomer restorations placed in school children in an outreach setting in rural areas in South Africa over a 2-year period, when placed using either ART…
- Trial name
- NCT05766696
- Testing
- Atraumatic Restorative Treatment (ART), Conventional Cavity Preparation
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- DMG Dental Material Gesellschaft mbH