Clinical trials: Paracetamol
Headache
Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache
The purpose of this trial is to determine if a single, oral dose of a fast release aspirin 1000 mg provides relief compared to acetaminophen 1000 mg and placebo in subjects with tension-type headache pain.
- Trial name
- Tarot Headache (NCT01552798)
- Testing
- Acetylsalicylic acid (Aspirin, BAY1019036), Acetaminophen
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bayer
Common Cold
Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America
This is a multicenter, prospective, randomized, double-blind, triple-dummy, parallel group, comparative, study designed to evaluate the efficacy of Ibuprofen (IBU) 200 mg/ Phenylephrine (PE) 10 mg and IBU 200 mg/ PE 10 mg/…
- Trial name
- NCT01938144
- Testing
- Advil Congestion Relief, Advil Allergy and Congestion Relief, Paracetamol
- Sponsor
- Pfizer
Respiratory Tract Infections, Fever
Placebo and Active Controlled Study to Compare the Antipyretic Efficacy of Aspirin® in Patients With Acute Febrile Upper Respiratory Tract Infections Suspected to be of Viral Origin
This study is addressed to patients suffering from an acute febrile upper respiratory tract infection suspected to be of viral origin.
- Trial name
- NCT01464944
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465), Paracetamol
- Where
- 9 sites in Russia, Ukraine
- Volunteers
- 392 people
- Sponsor
- Bayer
Acute Pain
A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of VX-993 in treating acute pain after a bunionectomy.
- Trial name
- NCT06619847
- Testing
- VX-993, HB/APAP
- Where
- 14 sites in United States
- Volunteers
- 367 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Healthy
Effects of Oxybutynin Topical Gel on Gastric Emptying
This study explores the effect of oxybutynin topical gel on gastric emptying
- Trial name
- NCT00926926
- Testing
- Oxybutynin Chloride Gel
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Watson Pharmaceuticals
Acute Myeloid Leukemia
A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
This open-label, entry-into-human (EIH) study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of RO7283420.
- Trial name
- NCT04580121
- Testing
- RO7283420, Tocilizumab, Dasatinib
- Where
- 23 sites in United States, Australia and 8 more
- Volunteers
- 59 people
- Sponsor
- Hoffmann-La Roche
Pneumococcal Vaccines
Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13®
The purposes of this study are assess the immunological response (measure the amount of antibodies, i.e. proteins that fight off germs) produced by children after they have been given the 13-valent pneumococcal vaccine (13vPnC)…
- Trial name
- NCT01392378
- Testing
- 13-valent pneumococcal conjugate vaccine, INFANRIX hexa, Paracetamol
- Where
- 14 sites in Poland
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain
A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental Pain
The purpose of this study is to evaluate how well a fixed combination of acetaminophen/naproxen sodium relieves postoperative dental pain compared with acetaminophen, naproxen sodium and placebo.
- Trial name
- NCT05761574
- Testing
- Acetaminophen/Naproxen Sodium Fixed Combination, Naproxen Sodium, Acetaminophen
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Analgesia
A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations
A study investigating the pharmacokinetic profiles of four extended release paracetamol formulations
- Trial name
- NCT01568749
- Testing
- Paracetamol, Paracetamol formulation 1, Paracetamol Formulation 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Arthritis, Rheumatoid
ULTRACET (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain.
The purpose of this study is to assess the effectiveness of ULTRACET® (a combination analgesic) as add-on therapy in rheumatoid arthritis patients taking an NSAID (e.g.
- Trial name
- NCT00246168
- Testing
- tramadol hydrochloride + acetaminophen
- Volunteers
- 277 people
- Sponsor
- Janssen Korea, Ltd., Korea
Plasma Cell Myeloma
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
Primary Objectives: Safety run-in Part: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM) Randomized Phase 3 Part: To…
- Trial name
- NCT04270409
- Testing
- Isatuximab SAR650984, Lenalidomide, Dexamethasone
- Where
- 105 sites in United States, Australia and 22 more
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Sanofi
Acute Pain
A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy
This is a Phase 2 randomized, double-blind, placebo-controlled, 3-arm, parallel design study to evaluate the efficacy and safety of VX-150 in treating acute pain following bunionectomy.
- Trial name
- NCT03206749
- Testing
- VX-150, HB/APAP
- Where
- 4 sites in United States
- Volunteers
- 243 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Bunion, Post-operative Pain
CPL-01 in the Management of Postoperative Pain After Bunionectomy
Subjects receive study drug during bunionectomy and are followed for pain and opioid use, with the hypothesis that those who receive CPL-01 will have less pain and less opioid use than either control arm.
- Trial name
- NCT05831449
- Testing
- Local anesthetic injection of CPL-01, Naropin, 0.5% Injectable Solution, Morphine rescue medication
- Where
- United States
- Volunteers
- 616 people
- Sponsor
- Cali Pharmaceuticals LLC
Pain
Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed
With this study researchers want to collect information on how long the pain relief lasts after a fixed dose of naproxen sodium or hydrocodone/acetaminophen or placebo (contains no medication) over 12 hours in subjects…
- Trial name
- NCT04307940
- Testing
- Naproxen Sodium (Aleve, BAY117031), Hydrocodone/Acetaminophen
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Bayer
Healthy
A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers
The objectives of this two-part study were to compare the single-dose and multiple-dose pharmacokinetics of extended release and immediate-release fixed combination formulations containing tramadol-HCl/acetaminophen and to…
- Trial name
- NCT00973232
- Testing
- DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), DDS-06C (650 mg acetaminophen and 75 mg tramadol), Zaldiar®
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Healthy
A Study of the Newly Formulated Tylenol Tablet (Acetaminophen) to the Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants
The purpose of this study is to evaluate the bioequivalence of the newly formulated Tylenol tablet (acetaminophen 650 mg) with respect to the Tylenol 8 Hour (H) Extended Release (ER) tablet (acetaminophen 650 mg) in healthy…
- Trial name
- NCT04230252
- Testing
- Acetaminophen
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Janssen Korea, Ltd., Korea
Ovarian Neoplasms, Endometrial Neoplasms
A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001)
Researchers are looking for new ways to treat advanced and recurrent endometrial cancer (EC) and ovarian cancer (OC). Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery.
- Trial name
- NCT07870278
- Testing
- MK-6255, CD8 PET Tracer, Acetaminophen
- Volunteers
- 80 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer (Advanced/Metastatic), HER2-positive Breast Cancer
Dual-Target CAR-NK Cells for Advanced Breast Cancer HER2+ TNBC
This study tests the safety and preliminary anti-tumor activity of an investigational dual-target chimeric antigen receptor natural killer (CAR-NK) cell therapy in adults with advanced breast cancer.
- Conditions
- Breast Cancer (Advanced/Metastatic), HER2-positive Breast Cancer, Triple-negative Breast Cancer
- Trial name
- NCT07510802
- Testing
- Dual-target CAR-NK cells, Lymphodepleting, Supportive care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Biotech
Acute Pain, Dysmenorrhea
Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima
What AE occur in routine clinical practice, what is the incidence of AE and Adverse Drug Reaction, how many patients present with AE symptoms related to a potential liver injury.
- Trial name
- NCT02910167
- Testing
- Hyoscine n-butylbromide, Paracetamol
- Where
- Peru
- Volunteers
- 360 people
- Sponsor
- Boehringer Ingelheim