Clinical trials: Rifampin
Healthy Volunteer
A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers
This open-label, two-arm, drug interaction study will investigate the effect of co-administration of rifampin or itraconazole on the pharmacokinetics of GDC-0032 in healthy volunteers.
- Trial name
- NCT01814709
- Testing
- GDC-0032, Itraconazole, Rifampin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Rifampin-Resistant Pulmonary Tuberculosis, Tuberculosis, Multidrug-Resistant (MDR-TB)
A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis Patients
This is a multicenter, randomized, double-blind, active-controlled Phase III study to evaluate the efficacy and safety of Sudapyridine (WX-081) combined with a background regimen (BR) in patients with rifampicin-resistant…
- Trial name
- WISH (NCT05824871)
- Testing
- Sudapyridine, Bedaquiline
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
Aneurysm, Graft Failure
Silver Graft All Comers Registry
This web based e-Registry will be international, multi-center and prospective. Silver Graft e-Registry to assess the long term clinical benefit of Silver Graft in an unselected patient population
- Conditions
- Aneurysm, Graft Failure, Graft Infection
- Trial name
- NCT01970605
- Testing
- Surgical reconstruction
- Where
- Germany
- Volunteers
- 230 people
- Sponsor
- B. Braun Melsungen AG
Healthy
Estimate The Effect Of Repeat-Dose Rifampin On The Pharmacokinetics Of CP-690,550 In Healthy Volunteers
The current study is designed to estimate the effect of rifampin (600 mg orally every 24 hours for 7 days) on pharmacokinetics of single 30 mg dose (CP-690,550) in normal healthy volunteers
- Trial name
- NCT01204112
- Testing
- Tasocitinib (CP-690,550) plus Rifampin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lymphoma, Including Chronic Lymphocytic Leukemia, Solid Tumors
A Study to Assess the Effect of Rifampin on the Metabolism of Navitoclax
This is an open-label, single or multiple center study to determine the interaction of rifampin with navitoclax (ABT-263) in approximately 12 subjects with cancer.
- Trial name
- NCT01121133
- Testing
- navitoclax, Rifampin
- Volunteers
- 12 people
- Sponsor
- AbbVie
Neoplasms
Effect of Rifampicin on the Pharmacokinetics of Apatinib
The primary purpose of this study is to investigate potential pharmacokinetic interaction in healthy volunteers when apatinib is administered in combination with rifampicin.
- Trial name
- NCT02836821
- Testing
- Apatinib Mesylate Tablets, Rifampicin Capsules
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Relative Bioavailability of Single Doses of Dabigatran Etexilate in Healthy Volunteers
Study to investigate whether and to what extent the suggested P-glycoprotein (P-gp) inducer rifampicin affects plasma exposure of dabigatran.
- Trial name
- NCT02173717
- Testing
- Dabigatran etexilate, Rifampicin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
Drug-drug Interaction Study of CTP-543 and Rifampin in Healthy Adult Subjects
This is a Phase 1 open-label study of the effect of rifampin on the pharmacokinetics of CTP-543 in healthy subjects.
- Trial name
- NCT04843540
- Testing
- CTP-543
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals
Rheumatoid Arthritis, Healthy Volunteers
Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.
The purpose of this study is to investigate the drug interaction between fostamatinib and rifampicin by comparing the safety, tolerability and plasma concentration of fostamatinib when administered alone and with rifampicin in…
- Trial name
- NCT01336218
- Testing
- fostamatinib, rifampicin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pharmacokinetics of YM178
Pharmacokinetic Interaction Study to Assess the Effect of Repeat Doses of Rifampin on Mirabegron (YM178) in Healthy Volunteers
The objective of the study is to assess the PK, safety and tolerability of a single dose of mirabegron alone and in combination with repeat doses of rifampin, a potent CYP3A4 inducer.
- Trial name
- NCT00776516
- Testing
- mirabegron, rifampin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Advanced Solid Tumors
Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors
This is a phase 1, open-label study designed to determine the interaction of rifampin with linifanib.
- Trial name
- NCT01401933
- Testing
- Linifanib, Rifampin
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Abbott
Healthy
A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants
The main purpose of this study is to assess the effect of itraconazole and rifampin on how fast selpercatinib gets into the blood stream and how long it takes the body to remove it when administered in healthy participants.
- Trial name
- NCT05338489
- Testing
- Selpercatinib, Itraconazole, Rifampin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Volunteers
Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort
The primary objective of the study is to determine the potential effects of multiple doses of rifampin and clarithromycin on the single dose pharmacokinetics (PK) of the deflazacort active metabolite (21 desacetyl-DFZ) in healthy…
- Trial name
- NCT02286635
- Testing
- Deflazacort and rifampin, Deflazacort and Clarithromycin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- PTC Therapeutics
Healthy Volunteers
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
The primary purpose of this study is to assess the effects of rifampin on the PK of brensocatib in Part 1 of the study and to assess the effects of esomeprazole on the PK of brensocatib in Part 2 of the study.
- Trial name
- NCT05826574
- Testing
- Brensocatib, Rifampin, Esomeprazole
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Parkinson's Disease
A Drug Interaction Study of KW-6356 and Clarithromycin or Rifampicin
The purpose of this study is to investigate the effects of CYP3A4/5 inhibitor or inducer on the pharmacokinetics of KW-6356 when CYP3A4/5 inhibitor or inducer is orally administered to healthy Japanese men for 7 days.
- Trial name
- NCT04070495
- Testing
- KW-6356, Clarithromycin, Rifampicin
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Tumor
To Assess the Effect of Rifampicin on the Pharmacokinetics of Eribulin Mesylate in Participants With Advanced Solid Tumors
The primary objective of this study was to assess the effect of cytochrome P450 3A4 enzyme (CYP3A4) induction by rifampicin on the pharmacokinetics (PK) of eribulin mesylate following intravenous (IV) administration in…
- Trial name
- NCT03002493
- Testing
- Eribulin mesylate, Rifampicin
- Where
- 2 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- Eisai Limited
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection
To determine if oral antibiotic treatment with CEM-102 and Rifampin is as effective and safe as the standard of care antibiotic therapy for the treatment of hip and knee prosthetic joint or spacer infections
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Infected Spacers
- Trial name
- NCT01756924
- Testing
- CEM-102, IV or Oral standard of care antibiotics, Rifampin
- Where
- 13 sites in United States
- Volunteers
- 14 people
- Sponsor
- Arrevus Inc.
Cancer
A Study of the Interaction of Rifampin and Vinflunine in Subjects With Advanced Cancer
The purpose of this study is to test how vinflunine interacts with rifampin in the human body
- Trial name
- NCT00534807
- Testing
- Vinflunine, Rifampin
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
Solid Tumors
A Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin
This is a phase I, open-label, 3 treatment period, fixed-sequence study in healthy non-Japanese male subjects, aged 18 to 65 years (inclusive), performed at a single study centre.
- Trial name
- NCT04118842
- Testing
- Savolitinib, Rifampicin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Drug Induced Constipation
Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118
Study in healthy volunteers to investigate the effects of Rifampin on the Pharmacokinetics of NKTR-118.
- Trial name
- NCT01533870
- Testing
- NKTR-118, Rifampin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- AstraZeneca