Clinical trials: sponsored by Regeneron Pharmaceuticals
Healthy
A Single-Dose Study of the Safety and Tolerability of REGN475(SAR164877) in Healthy Subjects
This is a randomized, double-blind, placebo-controlled single-dose study of the safety and tolerability of intravenously administered REGN475 in healthy volunteers.
- Trial name
- NCT00856310
- Testing
- REGN475 (SAR164877)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy
Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy Volunteers
This is a study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy Volunteers.
- Trial name
- NCT01484600
- Testing
- REGN668: Injection Rate 1, REGN668: Injection Rate 2
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Macular Degeneration
Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)
This study examines the effect of intravitreally administered VEGF Trap in patients with wet AMD. The purpose of this trial is to assess the ocular and systemic safety and tolerability of repeated intravitreal doses of VEGF Trap…
- Trial name
- NCT00320788
- Testing
- aflibercept injection (VEGF Trap-Eye, BAY86-5321)
- Where
- 18 sites in United States
- Volunteers
- 159 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis of the Knee
A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee
This is a double-blind, prospective, randomized study in which patients will be randomized to 1 of 4 treatment arms (3 active and 1 placebo).
- Trial name
- NCT00944892
- Testing
- REGN475
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Regeneron Pharmaceuticals
Sciatica
A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain
This is a phase 2, randomized, double-blind, parallel-group, single dose study to evaluate the safety and efficacy of 2 dose levels of REGN475 compared with placebo in patients with sciatic pain.
- Trial name
- NCT00991172
- Testing
- REGN475
- Where
- 30 sites in United States
- Volunteers
- 159 people
- Sponsor
- Regeneron Pharmaceuticals
Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria
Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)
Inflammatory symptoms of Cryopyrin-Associated Periodic Syndrome (CAPS) are due to mutations in a the NLRP-3 gene (previously known as Cold Induced Autoinflammatory Syndrome-1 or CIAS1).
- Conditions
- Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn
- Trial name
- NCT00288704
- Testing
- rilonacept 160 mg
- Where
- 24 sites in United States
- Volunteers
- 104 people
- Sponsor
- Regeneron Pharmaceuticals
Rheumatoid Arthritis
A Study of Tocilizumab in Patients With Rheumatoid Arthritis
This is an open-label, uncontrolled, observational study in patients with rheumatoid arthritis (RA) who are receiving tocilizumab concomitantly with methotrexate as part of their standard of care.
- Trial name
- NCT01187563
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Regeneron Pharmaceuticals
Diabetic Macular Edema
Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema
To assess the ocular and systemic safety and tolerability of a single intravitreal injection of VEGF Trap in patients with diabetic macular edema.
- Trial name
- NCT00320814
- Testing
- VEGF Trap-Eye
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Regeneron Pharmaceuticals
Neovascular Age Related Macular Degeneration
Safety and Tolerability of Intravitreal VEGF Trap Formulations in Subjects With Neovacular AMD
To assess the safety and tolerability of repeated intravitreal (ITV) administration of VEGF Trap.
- Trial name
- NCT00383370
- Testing
- VEGF Trap
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- Regeneron Pharmaceuticals
Chronic Kidney Disease, Anemia
Study of the Safety and Effectiveness of Rilonacept (IL-1 Trap) Administered Subcutaneously in Subjects With Non Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) and Anemia
Anemia of inflammation is a common complication in patients with chronic kidney disease (CKD). Patients with CKD and anemia of inflammation also exhibit decreased response to erythropoietic agents, even in the presence of…
- Trial name
- NCT00609544
- Testing
- Rilonacept
- Where
- 27 sites in United States
- Sponsor
- Regeneron Pharmaceuticals
Thermal Injury Pain
Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Pain Resulting From Thermal Injury
This is a randomized, double-blind, placebo-controlled, parallel-group, single-dose study of the efficacy of REGN475 in patients with pain due to thermal injury.
- Trial name
- NCT01053702
- Testing
- R475
- Where
- United States
- Sponsor
- Regeneron Pharmaceuticals