Clinical trials: Azacitidine, completed
Healthy
To Study the Oral Bioavailability of a New Combination Formation of Decitabine and Tetrahydrouridine in Healthy Males
This is an open-label, randomized, single-dose per period, two-period, crossover study to evaluate the relative bioavailability of decitabine and tetrahydrouridine ingested as a modified-release combination formulation compared…
- Trial name
- NCT05816356
- Testing
- Decitabine, Tetrahydrouridine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.
Healthy
Effect of Food on the Pharmacokinetics of Decitabine/Tetrahydrouridine Combination Capsules in Healthy Adult Subjects
This study is to investigate the effect of a high fat meal on the pharmacokinetics of decitabine and THU in healthy adults when administered as a modified release formulation of the 2 drugs in combination.
- Trial name
- NCT04086238
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.
Healthy
Randomized, Single-dose, Crossover Study of 4 Decitabine and Tetrahydrouridine (EPI01) Formulations in Healthy Subjects
To study the pharmacokinetic profiles of decitabine and tetrahydrouridine (THU) from 3 modified release formulations in healthy subjects.
- Trial name
- EPI01 (NCT03828084)
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EpiDestiny, Inc.
Cocaine Addiction
Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction
This study aims at testing for the impact of glutamatergic changes on drug craving in cocaine addiction, and to evaluate the effects of n-acetylcysteine (n-AC) on both glutamate homeostasis and craving using a randomized…
- Trial name
- CoGlu (NCT02626494)
- Testing
- N-Acetylcystein
- Where
- Switzerland
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Healthy
Pharmacokinetics of Asacol 2.4 g/Day and Lialda 2.4 g/Day in Healthy Volunteers
This study evaluated pharmacokinetics of 5-ASA and N-Ac-5-ASA associated with each of 3 regimens of oral mesalamine 2.4 g/day (Lialda 2.4 g/day 2 x 1.2 g every 24 hours, Asacol® 6 x 400 mg every 24 hours, or Asacol 2 x 400 mg…
- Trial name
- NCT00751699
- Testing
- Asacol, Lialda
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Warner Chilcott