Clinical trials: Oxytocin
Social Intelligence
Effect of Intranasal Neuropeptide on Emotion Perception in Trait Anxiety
The purpose of this study is to learn more about how emotional processing may be affected by a hormone called oxytocin. Oxytocin is a hormone that occurs naturally in the body, and may play an important role in the way that the…
- Trial name
- NCT01551303
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Human-Animal Bond, Human-Animal Interaction
Oxytocin Pathways and the Health Effects of Human-Animal Interaction
This study investigates the roles of oxytocin pathways in human-animal interaction.
- Trial name
- NCT03852264
- Testing
- Pet dog, Unfamiliar dog, Nonsocial control
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Interoception
The Modulatory Effect of Oxytocin on Interoception
This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.
- Trial name
- NCT03074409
- Testing
- oxytocin
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Postpartum Hemorrhage, Uterine Atony
Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial
The aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH).
- Trial name
- NCT03584854
- Testing
- 15-methyl prostaglandin F2α, Methylergonovine Maleate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post Partum Hemorrhage
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
Background Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide accounting for 25% of maternal deaths. In Zimbabwe PPH is the second most common cause of death.
- Trial name
- NCT03463993
- Testing
- Tranexamic Acid, Oxytocin
- Where
- 2 sites in Zimbabwe
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Body Dysmorphic Disorder, Obsessive-compulsive Disorder
Oxytocin Administration in BDD and OCD
The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and…
- Trial name
- NCT02671266
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Induction of Labor in Multiparous Women
A Study Comparing Vaginal Misoprostol and Intravenous Oxytocin for Induction of Labor
This study will compare the effectiveness of vaginal misoprostol (Cytotec) and intravenous oxytocin (Pitocin) in multiparous women who present at term for labor induction.
- Trial name
- NCT01634854
- Testing
- Vaginal Misoprostol, Intravenous Oxytocin
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Aging
Oxytocin's Effect on Socioemotional Aging
This study will investigate the extent to which intranasal oxytocin affects changes in social decision making and evaluations of others.
- Trial name
- NCT01823146
- Testing
- Oxytocin spray
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Florida
Maternal Behavior, Maternal Addiction
Oxytocin and Brain Responses in Maternal Addiction
A prior study by the principal investigator of this project identified dopamine- and oxytocin-related brain pathways that showed a diminished response when addicted mothers viewed the faces of their own vs.
- Trial name
- NCT02979093
- Testing
- Oxytocin, Functional MRI scanning
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Lane Strathearn, MBBS PhD
Autism, Autism Spectrum Disorder
Autism Oxytocin Brain Project
The main goal of the study is to look at the effects of intranasal oxytocin on the brain in Autism Spectrum Disorder (ASD). Oxytocin is a hormone that exists naturally in the body and the brain, affecting a wide range of social…
- Trial name
- NCT03033784
- Testing
- 8 International Units (IU) of Oxytocin, 24IU of Oxytocin, 48IU of Oxytocin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Emory University
Healthy
Neurobiological Bases of Paternal Nurturance
The overall goal of this project is to identify the genetic, hormonal, and neurobiological influences on paternal nurturing behavior and to determine if fathers' neural responses to infants can be modulated by neuropeptides known…
- Trial name
- NCT02223429
- Testing
- Oxytocin, Vasopressin
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- James K. Rilling, PhD
Pregnancy
A Randomized Comparison of Transcervical Foley Bulb With Vaginal Misoprostol to Vaginal Misoprostol Alone for Induction of Labor
A randomized, prospective trial will be offered to women admitted to the Roosevelt Hospital labor floor for labor induction. The hypothesis is that the simultaneous use of a foley bulb together with vaginal misoprostol will…
- Trial name
- NCT02566005
- Testing
- misoprostol, Foley bulb
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Acute Pain, Chronic Pain
Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin
The goal of this clinical trial is to learn about oxytocin ( a naturally occurring hormone made in the brain that transmits messages) and the effects it may have on thermal heat pain after intravenous administration.
- Conditions
- Acute Pain, Chronic Pain, Healthy Volunteer
- Trial name
- NCT05929339
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
AOD Use, Abuse, and Dependence
Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers
This is a randomized, placebo controlled, double blind crossover study of the effects of intranasal oxytocin on social cognition, implicit preferences and craving in moderate to heavy social alcohol drinkers.
- Trial name
- NCT01829516
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Substance Misuse, Interpersonal Conflict
Oxytocin for Couples Conflict Resolution
Oxytocin is a promising new medication found to have positive effects on prosocial behavior, reduce negative affect such as fear and anxiety, and reduce stress-induced addictive behaviors.
- Conditions
- Substance Misuse, Interpersonal Conflict, Neuroendocrine Reactivity
- Trial name
- NCT02941692
- Testing
- Oxytocin
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parent-Child Relations, Maternal Behavior
A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Childhood adversity affects almost two-thirds of the US population, is a major risk factor for the leading causes of disease and increases US economic health burdens.
- Conditions
- Parent-Child Relations, Maternal Behavior, Infant Behavior
- Trial name
- NCT04818112
- Testing
- ATVV, Attention control
- Where
- 2 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Arizona