Clinical trials: Propofol, completed
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Minimal Flow Anesthesia, General Anaesthesia
Minimal Flow Anesthesia and Infection Risk
This study is being done to find out if the heat and moisture that build up during minimal flow anesthesia can lead to the growth of germs (microorganisms) inside the anesthesia equipment.
- Conditions
- Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia, Infection Risk
- Trial name
- NCT07092046
- Testing
- Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Laparoscopic Hepatectomy
The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time
This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions…
- Trial name
- NCT07611344
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Xuyu Zhang
Effect of Patient Awareness on Incidence and Severity of Propofol Injection Induced Pain
Effect Of Patient Awareness About Possibility Of Occurrence Of Pain During Propofol Injection On The Rate Of Incidence And Severity Of Pain During Injection .
Propofol is the most common intravenous (IV) anesthetic agent, used for anesthesia induction and maintenance during surgeries due to its rapid onset and short duration.
- Trial name
- No acronym (NCT05886972)
- Testing
- Awareness about propofol injection induced pain
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Comparison of the Effects of Propofol and Nasal Dexmedetomidine
Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and Delirium
Dental pain and anxiety are quite common in pediatric patients. However, due to children's inability to express their fears and lack of knowledge about the procedures to be performed, these symptoms have often been misunderstood…
- Trial name
- NCT06466915
- Testing
- Dexmedetomidine, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Anesthesia, Tooth Extraction
Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery
The purpose of this pilot study was to compare two commonly employed intravenous drug combinations; I) nitrous oxide, midazolam, fentanyl, and ketamine and II) the same combination with substitution of propofol for ketamine, for…
- Trial name
- NCT06867068
- Testing
- Midazolam Hydrochloride, Fentanyl, Ketamine
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy
Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients
Background: Adenotonsillectomy is one of the most common pediatric surgeries and is often complicated by postoperative emergence agitation (POEA), a short-lived but distressing state of confusion and restlessness after…
- Trial name
- POEA (NCT07433231)
- Testing
- Magnesium sulfate (MgSO4) infusion, Propofol bolus, Ketamine bolus
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ayfer Kaya Gök
General Anesthesia
Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users
Part 1: To determine the doses of IV HSK3486 and propofol for use in Part 2, the abuse potential part of the study. Part 2: To evaluate the abuse potential of HSK3486 compared with propofol when administered IV to healthy…
- Trial name
- NCT07404306
- Testing
- HSK3486, propofol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Patients Undergoing Rigid Bronchoscopy
A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor
Standard ASA fasting guidelines will be followed. IV 20 gauge cannula will be inserted and dedicated to the infusion drugs. Standard ASA monitors will be attached, and baseline heart rate (HR), mean arterial blood pressure (MAP)…
- Trial name
- NCT07409935
- Testing
- Propofol saline, Propofol Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Perioperative Pain
Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation
When someone experiences a shoulder dislocation, it can be extremely painful. Emergency physicians often choose to use conscious sedation to help reduce the pain.
- Trial name
- NCT06034873
- Testing
- Propofol injection and fentanyl, Bupivacain
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Benha University
Propofol Injection Pain
Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain
The goal of this clinical trial was to evaluate methods to prevent pain on intravenous administration of propofol during induction of anesthesia.
- Trial name
- BBLP (NCT07285980)
- Testing
- propofol, Lidocaine - Propofol Mixture, Lidocaine - Bier Block
- Where
- Tunisia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Asma Ladib
Anesthesia
Comparison of Procedural Sedation in TEE
The objective of this proposal is to conduct a prospective randomized study comparing the utility of sedating patients undergoing transesophageal echocardiographic studies with a novel, recently-FDA-approved sedative agent…
- Trial name
- NCT06129188
- Testing
- Remimazolam, Propofol
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Dexmedetomidine Induced Sedation, Nasal Administration
Efficacy Study of Dexmedetomidine Nasal Spray Combined With Propofol for Deep Sedation in ERCP
This prospective randomized single-blind study evaluated the safety and efficacy of combining dexmedetomidine nasal spray with propofol for ERCP (Endoscopic Retrograde Cholangiopancreatography) sedation in eligible patients aged…
- Conditions
- Dexmedetomidine Induced Sedation, Nasal Administration, Sprays
- Trial name
- NCT07204106
- Testing
- Dexmedetomidine Injection (nasal spray) + Propofol Injection + Sufentanil Injection, Normal Saline (nasal spray) + Dexmedetomidine Injection (intravenous) + Propofol Injection + Sufentanil Injection, Regular sedation protocol
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shiyou Wei
Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
This is a multicenter, randomized, double-blinded, propofol-controlled, Phase 3 clinical study to evaluate the efficacy and safety of HSK3486 for induction of general anesthesia in adults undergoing elective surgery.
- Trial name
- NCT04711837
- Testing
- HSK3486, Propofol
- Where
- 13 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Emergence Agitation
Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: Which drug is more effective in preventing the appearance of Emergence…
- Trial name
- NCT06312618
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Quality of Recovery, Pain, Postoperative
Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free Anesthesia
The aim of this study is to compare the quality of recovery from general anesthesia and surgery using the quality of recovery 15 item scale (QoR-15) for participant's receiving opioid-Sparing anesthesia with those receiving…
- Conditions
- Quality of Recovery, Pain, Postoperative, Elective Laparoscopic Cholecystectomy
- Trial name
- NCT06343753
- Testing
- Opioid free analgesia, Opioid based Anesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Allergic Reaction, Hypersensitivity
Standardised Drug Provocation Testing in Perioperative Hypersensitivity
The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for perioperative…
- Conditions
- Allergic Reaction, Hypersensitivity, Perioperative Complication, Anaphylaxis
- Trial name
- NCT06065137
- Testing
- Full dose DPT with propofol, Full dose DPT with ketamine, Full dose DPT with etomidate
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp