Clinical trials: Vancomycin, completed
Pharmacokinetics and Pharmacodynamics
Vancomycin Dose Optimization in Obesity
The goal of this clinical trial is to learn how to optimize vancomycin dosing in obese adults based on weight and kidney function. It will also assess the safety of different vancomycin dosing strategies.
- Trial name
- NCT06601257
- Testing
- Vancomycin (IV)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Microbial Colonization
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system.
- Trial name
- NCT03273296
- Testing
- Amoxicillin, Azithromycin, Vancomycin
- Where
- Finland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Healthy Volunteers
Microbiome Effect of Omadacycline on Healthy Volunteers
The goal of this study is to assess microbiome changes associated with omadacycline vs. comparators (moxifloxacin or oral vancomycin).
- Trial name
- NCT06030219
- Testing
- Omadacycline, Vancomycin Pill, Moxifloxacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Houston
Surgical Site Infection, Complication of Surgical Procedure
Topical Antibiotics in Surgical Site
Ankle fractures are one of the most common injuries in traumatology. It is the fourth most common fracture in general population after hip, wrist, and hand fractures.
- Trial name
- NCT05363462
- Testing
- Vancomycin 1000 MG
- Where
- Mexico
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Rabies Human
Responses to Rabies Vaccine in Adults With or Without Antibiotics
The use of antibiotics changes micro-organisms in the intestines which may impact the body's vaccine immune response and alter the effectiveness of the rabies vaccine. There will be two randomized groups (1:1 randomization).
- Trial name
- NCT03557008
- Testing
- Rabies Vaccine, Metronidazole, Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Surgical Site Infection
Application of Powdered Vancomycin in the Surgical Wound in Haiti
Vancomycin, a tricyclic glycopeptide antibiotic, was originally indicated for the treatment of penicillin-resistant S. Aureus. It has a bactericidal action, inhibiting the biosynthesis of the cell wall of Gram-positive bacteria.
- Trial name
- NCT05535725
- Testing
- application of powdered vancomycin in the surgical wound as prophylaxis against the occurrence of surgical site infection
- Where
- Haiti
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Clinique Ortos
Human Microbiome
A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin
This clinical trial is intended to evaluate the effects of the changes in intestinal microbiome by antibiotics (PO vancomycin) on the pharmacokinetic /pharmacodynamic and safety profiles of metformin in healthy male volunteers.
- Trial name
- NCT03809260
- Testing
- Metformin (part 1), Vancomycin, Metformin (part 2)
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Volunteers
First-in-human Study of VE303 in Healthy Adult Volunteers
This study was designed to evaluate safety and tolerability of a range of doses of VE303 in healthy adult volunteers. The study also evaluated pharmacokinetics of intestinal colonization by the VE303 strains and pharmacodynamics…
- Trial name
- NCT04236778
- Testing
- VE303, Oral Vancomycin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Vedanta Biosciences, Inc.
Nephrolithiasis, Urinary Tract Infections
A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])
When patients are going to have surgery to remove large kidney stones (percutaneous nephrolithotomy [PCNL]), it is not clear whether the patients benefit from a course of prophylactic preoperative oral antibiotics; currently both…
- Trial name
- NCT02384200
- Testing
- nitrofurantoin monohydrate/macrocrystalline capsules, ampicillin, gentamicin
- Where
- 8 sites in United States, Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the study is to compare whether a center-wide policy of incremental antibiotic therapy will reduce CIED infection rate compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01628666
- Testing
- Incremental, Conventional
- Where
- Canada
- Volunteers
- 12,814 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Determine the benefit of oral vancomycin therapy for Primary Sclerosing Cholangitis.
- Trial name
- PSC (NCT01802073)
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Influenza
Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics
The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the…
- Trial name
- VAX-002 (NCT02154061)
- Testing
- IIV Flu Vaccine, Metronidazole, Neomycin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Simvastatin Pharmacokinetics and Gut Microbiome
Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers
This phase 1 clinical trial is to evaluate the effects of the environmental change in intestine by antibiotics on the pharmacokinetic characteristics of simvastatin in healthy male volunteers.
- Trial name
- NCT03403972
- Testing
- Vancomycin 250Mg Capsule
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Skin Diseases, Infectious, Staphylococcal Skin Infections
Clinical and Economic Outcomes of Ceftaroline Fosamil for ABSSSI Documented or at Risk of MRSA
The proposed study is a prospective, open-label, randomized, multi-center trial of ceftaroline versus vancomycin for the treatment of ABSSSI in patients documented or at risk for MRSA.
- Trial name
- NCT02582203
- Testing
- Ceftaroline, Vancomycin
- Where
- 3 sites in United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Endotoxemia
The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia
The purpose of this study is to determine whether treatment with antibiotics, which harm the gut flora, causes the immune system to be less effective.
- Trial name
- MISSION-2 (NCT02127749)
- Testing
- Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes, Obesity
Eradication of Gut Microbiota
The aim of the study is to assess the effect of eradication of gut microbiota on 1) glucose metabolism including postprandial plasma responses of the incretin hormones GIP and GLP-1, insulin, C-peptide and glucagon, 2)…
- Conditions
- Diabetes, Obesity, Osteoporosis, Inflammation
- Trial name
- ERA (NCT01633762)
- Testing
- meropenem, gentamicin, vancomycin (together)
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the pilot study is to compare whether a centre-wide policy of incremental antibiotic therapy will reduce pacemaker infection compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01613092
- Testing
- Incremental, Cefazolin
- Where
- 2 sites in Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Healthy, Cystic Fibrosis
Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics
The study is carried out to evaluate the safety, tolerability and pharmacokinetics of AeroVanc inhalation powder in healthy volunteers, and in patients with cystic fibrosis.
- Trial name
- NCT01537666
- Testing
- AeroVanc, IV vancomycin hydrochloride
- Where
- 2 sites in Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Savara Inc.