Clinical trials: medical devices, open to volunteers
Mood Disorders, Anxiety Disorders
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain.
- Trial name
- NCT00397111
- Testing
- 7T Magnetic Resonance Imaging scanner
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Inherited Bone Marrow Failure Syndrome, Familial Platelet Disorder With Predisposition to Myeloid Malignancies
Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency
Background: Runt-related transcription factor 1 (RUNX1) gene regulates the formation of blood cells. People with mutations of this gene may bleed or bruise easily; they are also at higher risk of getting cancers of the blood…
- Trial name
- NCT06090669
- Testing
- TruSight Oncology, imatinib
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Aesthetic
PLLA and CaHA-R for Aesthetic Rejuvenation
Skin ageing is intricately linked to collagen degradation caused by internal and external factors. External factors contributing to ageing include ultraviolet rays, smoking, heat, and air pollution, and follow a distribution…
- Trial name
- NCT07202117
- Testing
- Sculptra Aesthetic, Radiesse
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Metabolic Disease, Obesity
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
Background: Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels.
- Conditions
- Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy
- Trial name
- NCT01143454
- Testing
- NSR IDE-MRI: Research pulse sequences
- Where
- 3 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
CAD
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
Background: Researchers are testing version of a system known as a magnetic resonance imagining (MRI) scanner that uses strong magnetic fields, radio waves and the like to create images of the organs in the body.
- Trial name
- NCT03331380
- Testing
- MRI scan - obj 1, MRI scans - obj 2, MRI scans - obj 3
- Where
- United States
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects
This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery disease.
- Trial name
- NIMO-Healthy (NCT06000540)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University
Skin Physiology After Fractional CO₂ Laser Treatment, Skin Physiology After Thermage Treatment
Pre- and Post-procedure Skin Knowledge Study
The goal of this exploratory clinical trial is to characterize and compare skin clinical signs, skin physiology and subjective well-being before and after CO₂ fractional laser or Thermage treatment.
- Trial name
- NCT07895303
- Testing
- CO₂ fractional laser skin treatment, Thermage skin tightening treatment, Neutral broad-spectrum sunscreen
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obesity
Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments
Background Obesity and physical inactivity contribute substantially to cardiovascular disease risk, diabetes, hypertension, and dyslipidemia.
- Trial name
- NCT03288207
- Testing
- AMRA(r) Researcher Image reconstruction software, MRI: radiofrequency coils (Device Manufacturer: Siemens Medical Solutions USA, Inc.), MRI: Research pulse sequences (Device Manufacturer: NIH)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Poor Sleep Quality, Gut Microbiome
The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm.
This study examines whether two continuous weeks of overnight active temperature regulation (via the Eight Sleep Pod) use affects gut microbiome composition, inflammation, and the body's daily temperature and blood pressure…
- Conditions
- Poor Sleep Quality, Gut Microbiome, Gut Health, Inflammation
- Trial name
- NCT07848594
- Testing
- Overnight Active Temperature Regulation: Eight Sleep Pod System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eight Sleep Inc.
Pregnancy
Predicate and Lay User-HCP Comparison Study of a Multi-Level Urine hCG Pregnancy Test
Study volunteers will be required to conduct a home pregnancy test (HPT) at the trial center and provide a sample of urine from the same void for further testing.
- Trial name
- NCT06516211
- Testing
- Clara Pregnancy Test, Professional Marketed Pregnancy Test
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Exercise-Induced Muscle Fatigue, Fatigue Recovery
Acute Effects of High-Intensity Laser Therapy on Pain, Muscle Stiffness, and Grip Strength in Healthy Adults
The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults.
- Trial name
- HILT (NCT07895862)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
COVID-19 Respiratory Infection, Influenza
Light-based Immunomodulation for Guarding Against Human Respiratory Tract Infections
The purpose of trial is to determine if daily usage of a photobiomodulation device will decrease the incidence of upper respiratory tract infections (URI) due to COVID, influenza or other viruses.The RD-X10 device is handheld…
- Trial name
- LIGHT (NCT07610967)
- Testing
- RD-X19
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- David Moss
Myeloid Chimerism
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
Background: Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some…
- Trial name
- NCT04008368
- Testing
- CliniMACS CD34 Reagent
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Multiple Sclerosis
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than…
- Trial name
- DIIVA-MS (NCT06495138)
- Testing
- StableEyes
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Emory University
Chronic Migraine Headache
Laser Acupuncture for Chronic Migraine: Clinical Response, Traditional Chinese Medicine Syndrome Patterns, and Brain Function
The PRISM-CM study will test whether 810-nanometer laser acupuncture reduces migraine days and related symptoms in adults with chronic migraine.
- Trial name
- PRISM-CM (NCT07891585)
- Testing
- 810 nm laser acupuncture
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Facial Skin Laxity
VISION Study: Visualization-Guided SMAS Treatment to Optimize Nonsurgical Lifting
The VISION study is a prospective, randomized, single-center, split-face Phase IV clinical trial evaluating whether customized multi-depth microfocused ultrasound with visualization (Ultherapy PRIME) targeting the…
- Trial name
- NCT07890987
- Testing
- Microfocused Ultrasound with Visualization (MFU-V), multi Microfocused Ultrasound with Visualization (MFU-V)
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ocean Clinic
Transcranial Electric Stimulation
Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking
This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults.
- Trial name
- MINT (NCT07752745)
- Testing
- TES-TI with hdEEG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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