Clinical trials: sponsored by Kaiser Permanente
Dementia, Alzheimer Disease
The Brain Health Study: A Pragmatic, Patient-Centered Trial
The eRADAR Brain Health Study seeks to refine and test a novel, low-cost strategy for increasing dementia detection within primary care.
- Trial name
- NCT05356702
- Testing
- Brain Health Assessment
- Where
- 5 sites in United States
- Volunteers
- 3,417 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes Mellitus
ASCEND: ApproacheS to CHC ImplEmeNtation of SDH Data Collection and Action
This work will test a set of strategies for helping community health centers (CHCs) routinely identify and take action on the SDH-related needs of patients with / at risk for DM using a stakeholder-driven process to develop…
- Trial name
- ASCEND (NCT03607617)
- Testing
- SDH Tool
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Colon Cancer
Study of Colorectal Cancer Screening Options
The investigators propose to evaluate Guardant Health's commercially available colorectal cancer screening assay(Guardant SHIELD) in individuals who are not up to date with CRC screening.
- Trial name
- NCT05987709
- Testing
- GuardantSHIELD Blood Test
- Where
- United States
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
COVID-19 Testing
COVID-19 Antibody and Reinfection Study
The goal of this study is to establish a cohort of Kaiser Permanente Colorado (KPCO) members who have and have not had COVID-19 infection for serial antibody testing and PCR testing to: 1.
- Trial name
- NCT05365750
- Where
- United States
- Volunteers
- 4,235 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hereditary Cancer Syndrome
Cancer Health Assessments Reaching Many
The CHARM (Cancer Health Assessment Reaching Many) study will assess the utility of clinical exome sequencing and how it affects care in diverse populations.
- Trial name
- CHARM (NCT03426878)
- Testing
- Modified genetic counseling, Traditional genetic counseling
- Where
- 2 sites in United States
- Volunteers
- 967 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Mental Health
Novel Methods for Implementing Measurement-Based Care for Youth in Low-resource Environments
This study will visit 4 community mental health clinics in Washington state and work with clinic staff to find out if staff are regularly evaluating clinical outcomes using questionnaires (which is also called measurement-based…
- Trial name
- NIMBLE (NCT05644756)
- Testing
- IMPACT Methods to Identify and Prioritize Determinants (Challenge I), Challenge and Match strategies to Prioritized Determinants (Challenge II)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Distress, Cancer
POEM (Practice Of Embracing Each Moment) STUDY
A cancer diagnosis is extremely stressful, emotionally challenging, and often life-altering for both patients and their loved ones.
- Conditions
- Distress, Cancer, Chemotherapy Effect
- Trial name
- POEM (NCT03078608)
- Testing
- Mindfulness meditation program (administered via mobile app), Progressive muscle relaxation (via mobile app)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Influenza, Pneumonia
Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years
The overall objective of this study is to describe the effectiveness of Flublok Quadrivalent vaccine compared to standard dose inactivated influenza vaccine (SD-IIV) in adults 18 through 64 years of age.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Acute Myocardial Infarction
- Trial name
- NCT03694392
- Testing
- Flublok Quadrivalent, Standard Dose Inactivated Influenza Vaccine (SD-IIV)
- Where
- United States
- Volunteers
- 2,776,278 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Attack, Stroke
CV Wizard: Does a Clinical Decision Support Tool Improve CVD Risk Factor Control in Safety Net Clinics?
This project aims to reduce disparities in cardiovascular disease (CVD) risk factor control and in rates of heart attacks and strokes among the low-income, racially / ethnically diverse Americans who receive primary care at…
- Conditions
- Heart Attack, Stroke, Cardiovascular Diseases
- Trial name
- CV_WIZARD (NCT03001713)
- Testing
- CV WIZARD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alcohol, Drinking, Alcohol Use Disorder
Sustaining Patient-centered Alcohol-related Care
Alcohol use is the third greatest cause of disability and death for US adults. Care for unhealthy alcohol use is lacking in most primary care settings.
- Trial name
- SPARC (NCT02675777)
- Testing
- Quality Improvement Intervention
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Child Behavior Disorders
Safer Use of Antipsychotics in Youth
This study tests the effectiveness of an intervention treatment algorithm vs. usual care control in a practical clinical trial. Control arm providers will receive a standard medication alert in the electronic medical record (EMR)…
- Trial name
- SUAY (NCT03448575)
- Testing
- Control - Provider Medication Alert Only, Intervention - Alert + CAP Review AND Enhanced BH Access
- Where
- 4 sites in United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Sedentary Lifestyle
Healthy Aging Resources to Thrive (HART)
Healthy Aging Resources to Thrive (HART) uses a rigorous two-stage randomized control design, adapted and refined based on pilot studies, to test a novel intervention to reduce sitting time in older adults.
- Trial name
- HART (NCT03739762)
- Testing
- i-STAND, Healthy Living control
- Where
- United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Breast Cancer
Radiologic Evaluation and Breast Density (READ)
The purpose of this study is to determine whether cessation of hormone replacement therapy for one or two months before a screening mammogram will improve its performance by decreasing breast density.
- Trial name
- NCT00117663
- Testing
- temporary discontinuation of hormone therapy for 1 month, temporary discontinuation of hormone therapy for 2 months
- Where
- United States
- Volunteers
- 1,704 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Anterior Vaginal Wall Prolapse, Cystocele
Anterior Colporrhaphy Versus Cystocele Repair Using Polypropylene Mesh or Porcine Dermis
The purpose of this study is to evaluate the success rate of cystocele repair using polypropylene mesh or porcine dermis compared to that of anterior colporrhaphy in a prospective randomized fashion.
- Conditions
- Anterior Vaginal Wall Prolapse, Cystocele, Pelvic Organ Prolapse
- Trial name
- OARS (NCT01393171)
- Testing
- Polypropylene mesh (Polyform by Boston Scientific), Porcine Dermis (Pelvicol by CRBard), Anterior Colporrhaphy
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Preventive Health Services, Health Communication
Patients Engaged in Prevention: Enhancing Outreach to Increase Patient Engagement in Diabetes Prevention
This study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to…
- Trial name
- PEP (NCT03550066)
- Testing
- Values affirmation, No affirmation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Tobacco Use Disorder, Smoking Cessation
Development of a mHealth Intervention for Ambivalent Smokers
The current pilot study will assess the feasibility and acceptability of a novel mHealth app designed for people who are ambivalent about quitting smoking.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Motivation, Behavior, Smoking
- Trial name
- NCT04560868
- Testing
- Control mHealth program, Experimental mHealth program, Nicotine patch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Cardiovascular Disease
SPREAD-NET: PRactices Enabling Adapting and Disseminating in the Safety NET
The investigators propose to compare the effectiveness of 3 strategies (low, medium, high intensity) at supporting CHCs' implementation of the ALL Initiative (an intervention shown to reduce patients' cardiovascular disease (CVD)…
- Trial name
- SPREAD-NET (NCT02325531)
- Testing
- Low support, Medium support, High support
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes
Addressing Social Determinants of Health & Diabetes Self-Management in Vulnerable Populations
In this pilot and feasibility study, the investigator will randomize 100 African-American, Hispanic, and/or Medicaid (all race/ethnicities) patients from KPNW with A1C ≥ 8 to one of two 6-month interventions: 1) patient…
- Trial name
- NCT03802825
- Testing
- Diabetes Self-Management Training, Standard Patient Navigation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Blood Pressure
Blood Pressure Checks for Diagnosing Hypertension (BP-CHECK)
Hypertension is usually diagnosed at a clinic or doctor's office when a patient has blood pressure (BP) that is high for several measurements.
- Trial name
- NCT03130257
- Testing
- Clinic Blood Pressure Measurement, Home Blood Pressure Measurement, Kiosk Blood Pressure Measurement
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes, Weight Loss
De Por Vida: A Diabetes Risk Reduction Intervention for Hispanic Women
This pragmatic randomized clinical trial will assess the efficacy, cost, and sustainability of a culturally tailored weight-loss program targeting obese Hispanic women with pre-diabetes or T2D.
- Conditions
- Diabetes, Weight Loss, PreDiabetes, Obesity
- Trial name
- NCT03113916
- Testing
- Behavioural Lifestyle Intervention
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente