Clinical trials: sponsored by Icahn School of Medicine at Mount Sinai
Sleep Disturbances, Depression
Methodology Issues in a Tailored Light Treatment for Persons With Dementia
Tailored light treatment will increase sleep efficiency, reduce depression and reduce agitation scores in those with Alzheimer's disease and related dementia
- Trial name
- NCT01816152
- Testing
- High Active intervention, Inactive intervention, Mid Level Active Intervention
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Physical Activity
Molecular Transducers of Physical Activity Consortium
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA).
- Trial name
- MoTrPAC (NCT03960827)
- Testing
- EE Training, RE Training
- Where
- 11 sites in United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Physical Activity
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA).
- Trial name
- MoTrPAC (NCT04151199)
- Testing
- EE Training
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bulimia Nervosa
Self-Control in Bulimia Nervosa
This study examines the influence of acute fasting and eating on self-control in adult females with and without bulimia nervosa (BN).
- Trial name
- NCT04409457
- Testing
- fasting state, fed state, magnetic resonance imaging
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
HIV/AIDS, PrEP
Pre-Exposure Prophylaxis in the Emergency Department
Despite an increasing armamentarium of behavioral and biomedical HIV prevention methods, since 2010 rates of new infection have remained around 40,000 annually.
- Trial name
- PrEPPED (NCT04429971)
- Testing
- PrEP screening program, PrEP starter pack
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Weight Loss, Obesity
Noom Health for Weight Management
The goals of the study are to use the Noom mobile app to help individuals with weight loss and weight loss maintenance. This project will test the comparative efficacy of Noom Health vs.
- Trial name
- NCT04797169
- Testing
- Noom Health, Noom Digital Health
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment, Alzheimer Disease
Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment
The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory.
- Trial name
- NCT05411822
- Testing
- Lighting Intervention Blue light, Lighting Intervention Green light, Dim-light control condition
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Seborrheic Dermatitis
Ruxolitinib in Seborrheic Dermatitis
This study is an open-label prospective interventional trial that will assess the efficacy of ruxolitinib in the treatment of seborrheic dermatitis.
- Trial name
- NCT05787860
- Testing
- Ruxolitinib 1.5% Cream
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anal High Grade Squamous Intraepithelial Lesion
The Effectiveness of High Resolution Microendoscopy for People Living With HIV
The investigators have developed a portable, battery-operated, mobile high-resolution microendoscope (mHRME) that provides subcellular images of the anal epithelium, delineating the cellular and morphologic changes associated…
- Trial name
- NCT04563754
- Testing
- mHRME (Mobile High resolution microendoscope), Proflavine Hemisulfate, High resolution anoscopy
- Where
- 3 sites in United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Spinal Cord Injury, Autonomic Dysreflexia
Treatment of Post-SCI Hypotension
While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters.
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Orthostatic Hypotension, Baroreceptor Integrity
- Trial name
- NCT02919917
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Accelerated/Blast-phase Myeloproliferative Neoplasm, Chronic-phase Myelofibrosis
Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation
The presence of IDH mutation is associated with worse survival in patients with myelofibrosis. Moreover IDH mutations are among the most frequently encountered events in MPNs that have progressed to acute myeloid leukemia.
- Conditions
- Accelerated/Blast-phase Myeloproliferative Neoplasm, Chronic-phase Myelofibrosis, IDH2 Mutation
- Trial name
- NCT04281498
- Testing
- Ruxolitinib, Enasidenib
- Where
- 11 sites in United States, Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- John Mascarenhas
Diabetes Mellitus
Study of Harmine in Healthy Subjects
The present study is a phase 1 dose escalation study of harmine in healthy volunteers. The primary goal of the trial is to determine the maximum tolerated dose of harmine.
- Trial name
- NCT05526430
- Testing
- Harmine Hydrochloride Capsules
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- James Murrough
Bilateral Hearing Loss, Healthy Aging
Dual-Task Cost in Bilateral Hearing Loss
The specific aims of the research study are: 1. Compare single-task gait parameters between individuals with hearing loss (HL) and age and education matched controls with normal hearing [normal vs moderate-profound hearing loss…
- Trial name
- NCT05540535
- Testing
- Gait assessment, Cognitive assessment
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- New York University
Breast Cancer
Increasing African Immigrant Women's Participation in Breast Cancer Screening
New York City (NYC) is home to a large and diverse immigrant population. Many of these groups face significant barriers to preventive health care, including lack of insurance, poor health care access and language difficulties.
- Trial name
- AIBCS (NCT04450264)
- Testing
- African Immigrant Breast Cancer Education Program
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hysterotomy
Barbed Suture for Hysterotomy Closure During Cesarean Section
This is a randomized controlled trial. The purpose of this study is to see if patients whose uterine incision (hysterotomy), at the time of scheduled cesarean section, is closed with barbed suture, have less blood loss compared…
- Trial name
- NCT04622267
- Testing
- Barbed suture, Standard antimicrobial suture
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity
Multi-level Supermarket Discount Study
The study team's objective is to test the effect of supermarket discount levels on fruit and vegetable (F\&V) and non-caloric beverage purchasing and consumption, as well as health outcomes.
- Trial name
- NCT04178824
- Testing
- Discount Intervention
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Attention Deficit Hyperactivity Disorder
Brain Dopamine Function in Adults With ADHD
The purpose of the study is to investigate the functional state of dopamine cells and the dopamine transporter in ADHD subjects and controls to assess the effects of chronic methylphenidate treatment on dopamine cell function and…
- Trial name
- Brookhaven (NCT00580814)
- Testing
- Experimental: methylphenidate treatment
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Colorectal Cancer
e-Motivación: Developing and Pilot Testing an App to Improve Latinos' Screening Colonoscopy Rates
Among Latinos, a fast growing and underserved population, Colorectal Cancer (CRC) is the third leading cause of cancer death in men and in women.
- Trial name
- NCT04987788
- Testing
- Motívate, Video link
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Screening Mammogram
Increasing Breast Cancer Screening in Chinese Immigrants
The long-term goal of this research is to increase breast cancer screening rates in NYC Chinese immigrants. The researchers plan to accomplish this objective by developing and testing a culturally- and linguistically-adapted…
- Trial name
- NCT05089292
- Testing
- Narrative breast health education
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai