Clinical trials: 5-Fluorouracil
Colorectal Cancer
Eniluracil and Surgery in Treating Patients With Primary or Metastatic Colorectal Cancer
RATIONALE: Eniluracil may increase the effectiveness of chemotherapy by blocking tumor enzymes that break down chemotherapy drugs.
- Trial name
- NCT00004195
- Testing
- eniluracil, conventional colon surgery
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Carcinoma, Pancreatic Ductal
The Combination Chemotherapy of SIRIOX as First- or Second-Line Chemotherapy for Pancreatic Cancer
Pancreatic cancer represents the most lethal of the common malignancies with a 5-year survival rate of less than 5%. For patients who are eligible for potentially curative resection, despite mortality and morbidity rates after…
- Trial name
- NCT03403101
- Testing
- S1, Oxaliplatin, Irinotecan
- Where
- 2 sites in China
- Volunteers
- 65 people
- Sponsor
- Fudan University
Colo-rectal Cancer
Study of Varsetatug Masetecan in Combination With Anti-Cancer Therapies in Colorectal Cancer
This is a non-registrational Phase 1/2, multicenter, open-label trial to evaluate the efficacy and safety of varsetatug masetecan combined with anti-cancer therapies in participants with unresectable metastatic colorectal cancer…
- Trial name
- NCT07900165
- Testing
- varsetatug masetecan, bevacizumab + 5-FU + leucovorin, bevacizumab
- Volunteers
- 368 people
- Sponsor
- CytomX Therapeutics
Colorectal Cancer
Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PETACC-6 (NCT00766155)
- Testing
- capecitabine, oxaliplatin
- Volunteers
- 1,094 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Anal Squamous Cell Carcinoma
Adaptive Radiation in Anal Cancer
This is a 20 patient pilot study to examine the feasibility of dose-adapted radiation therapy for the treatment of locally advanced anal squamous cell cancer.
- Trial name
- NCT05838391
- Testing
- Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery, Mitomycin-C, 5-Fluorouracil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Esophageal Cancer
Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer
The purpose of this study is to evaluate the safety and immune response of multiple peptides (URLC10, TTK, KOC1 VEGFR1, and VEGFR2) emulsified with Montanide ISA51 in combination with chemotherapy (CDDP, 5-FU) plus radiation…
- Trial name
- NCT00632333
- Testing
- URLC10, TTK, KOC1, VEGFR1, VEGFR2, cisplatin, fluorouracil
- Where
- Japan
- Volunteers
- 9 people
- Sponsor
- Teikyo University
Solid Carcinoma, 5-Fluorouracil Toxicity
Prevention of Chest Pain in Chemo-treated Cancer Patients
This is a prospective, exploratory, randomised clinical trial. Patients with diagnosed cancer that are to be treated with 5-fluorouracil (5-FU) will be randomised into standard oncological treatment or a cardiological assessment…
- Conditions
- Solid Carcinoma, 5-Fluorouracil Toxicity, Cardiotoxicity, Chemotherapeutic Toxicity
- Trial name
- CATCH (NCT03486340)
- Testing
- Cardiologic assessment
- Where
- Denmark
- Volunteers
- 218 people
- Sponsor
- Vejle Hospital
Actinic Keratoses
Combination Topical Therapy for Treatment of Scalp Actinic Keratoses
The aim of this study is to determine the effectiveness of combination calcipotriene 0.005% foam and 5% fluorouracil cream for the treatment of actinic keratoses on the scalp.
- Trial name
- NCT03996252
- Testing
- Calcipotriene 0.005% Foam, Efudex 5% Topical Cream
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tulane University
Efficacy, Self, Safety Issues
First-Line Treatment Induced With mFOLFOX6 and HLX04 Regimen, Following Combined With Serplulimab in MSS Initially Unresectable Metastatic Colorectal Cancer
This is a prospective, multi-center, randomized controlled clinical intervention study, aiming to explore the effectiveness and safety of mfolfox6 and hlx04 regimens combined with slulimumab as first-line treatment for MSS-type…
- Conditions
- Efficacy, Self, Safety Issues, Colo-rectal Cancer
- Trial name
- NCT06491355
- Testing
- mfolfox6 and hlx04 regimen and Serplulimab, mfolfox6 and hlx04 regimen
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Sir Run Run Shaw Hospital
Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction
Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)
The purpose of this study was to demonstrate superiority of treatment with avelumab versus continuation of first-line chemotherapy.
- Trial name
- NCT02625610
- Testing
- Avelumab, Oxaliplatin, 5-Fluorouracil
- Where
- 200 sites in United States, Australia and 15 more
- Volunteers
- 499 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Rectal Cancer
Avelumab With Chemoradiation in Locally Advanced Rectal Cancer
This trial is investigating the inclusion of avelumab post long-course chemo-radiotherapy in patients with resectable locally advanced rectal cancer.
- Trial name
- NCT03299660
- Testing
- Avelumab, 5 Fluorouracil, Capecitabine Pill
- Where
- 7 sites in Australia
- Volunteers
- 37 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Colorectal Neoplasms
Study of the GARFT Inhibitor AG2037 in Patients With Metastatic Colorectal Cancer Who Failed Treatment
To determine the response rate in patients with metastatic colorectal cancer who failed treatment with a 5-Fluorouracil/Leucovorin regimen and up to one other chemotherapeutic regimen (not including adjuvant chemotherapy).
- Trial name
- NCT00078468
- Testing
- PELITREXOL/AG-2037
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Pfizer
Pancreatic Adenocarcinoma Metastatic
QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer
This is a phase 1b/2 study to evaluate the safety and efficacy of NANT-008 in combination with 5-fluorouracil, bevacizumab, leucovorin, and oxaliplatin in patients with metastatic pancreatic adenocarcinoma.
- Trial name
- NCT03127124
- Testing
- NANT-008, Fluorouracil Injectable Product, Avastin Injectable Product
- Where
- United States
- Sponsor
- NantPharma, LLC
Liver Transplantation, Hepatocellular Carcinoma
Impact of Postoperative Adjuvant Chemotherapy in Patients With Hepatocellular Carcinoma After Liver Transplantation
The study is designed to investigate the effect of postoperative adjuvant chemotherapy in prevention of tumor recurrence and metastasis for hepatocellular carcinoma after liver transplantation.
- Conditions
- Liver Transplantation, Hepatocellular Carcinoma, Tumor Recurrence and Metastasis, Survival
- Trial name
- NCT01125020
- Testing
- gemcitabine and oxaliplatin, doxorubicin, 5-Fu and cisplatin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Locally Advanced Rectal Carcinoma
Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer
The goal of this clinical trial is to test the efficacy and safety in patients with locally advanced middle and lower rectal cancer.
- Trial name
- NeoCaCRT (NCT05792735)
- Testing
- Cadonilimab Injection, Short-course radiotherapy, Consolidation chemotherapy
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Shenzhen People's Hospital
Metastatic Colorectal Cancer
Phase II Trial to Assess FOLFIRI+Aflibercept Efficacy in Patients With Oxaliplatin-pretreated Metastatic Colorectal Cancer With or Without ACE Polymorphisms
The purpose of this study is to assess FOLFIRI+aflibercept efficacy in patients with or without ACE polymorphisms in terms of Progression-free survival (PFS).
- Trial name
- POLAF (NCT02970916)
- Testing
- FOLFIRI+aflibercept
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Colorectal Cancer
Bortezomib, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Rectal Cancer
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00280176
- Testing
- bortezomib, fluorouracil, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Nasopharyngeal Carcinoma
Nedaplatin in Treatment for Nasopharyngeal Carcinoma
To evaluate the efficacy of induction chemotherapy with nedaplatin, docetaxel and 5-Fluorouracil followed by concurrent nedaplatin combined with radical radiotherapy in locally advanced nasopharyngeal carcinoma.
- Trial name
- NCT04834206
- Testing
- Docetaxel, nedaplatin, fluorouracil, IMRT, Nedaplatin
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Digestive Cancer
Oxaliplatin in PIPAC for Nonresectable Peritoneal Metastases of Digestive Cancers
Current curative treatment of digestive peritoneal carcinomatosis consists of complete cytoreduction surgery associated with intraperitoneal chemotherapy.
- Trial name
- PIPOX (NCT03294252)
- Testing
- 5-Fluorouracil, L-Folinic acid, Oxaliplatin
- Where
- 3 sites in France
- Volunteers
- 34 people
- Sponsor
- Institut Cancerologie de l'Ouest
Vitamin D3
XELOX/mFOLFOX Plus Vitamin D3 vs. XELOX/mFOLFOX as Firstline Chemotherapy in mCRC
The study is a randomized,multicenter, double-blinded,phase III study. To explore the affection of vitamin D3 in combination with oxaliplatin plus fluoropyrimidine versus oxaliplatin plus fluoropyrimidine as first-line…
- Trial name
- NCT03389659
- Testing
- vitamin D3
- Volunteers
- 750 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
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