Clinical trials: Acetaminophen, completed
Bunion of Unspecified Foot, Bunionette of Unspecified Foot
Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study
Orthopedic surgeons frequently prescribe and over-prescribe narcotic pain medications during the postoperative period, despite the ongoing opioid crisis in the United States.
- Conditions
- Bunion of Unspecified Foot, Bunionette of Unspecified Foot, Hammertoe, Ankle Fractures
- Trial name
- NCT04771741
- Testing
- Acetominophen, Toradol, Meloxicam
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Prisma Health-Midlands
Postoperative Pain
PK and Safety After C-Section
The main goal of the study was to measure the amount of the active ingredients and other components of HTX-011 in plasma and expressed breast milk over time following postpartum administration in women undergoing a planned…
- Trial name
- NCT03955211
- Testing
- HTX-011, ZYNRELEF kit components for administration, MMA regimen
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Heron Therapeutics
Pain
Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills.
- Trial name
- NCT02848729
- Testing
- Oral Acetaminophen, IV Acetaminophen, IV Morphine
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Fever
Safety of Intravenous Acetaminophen Vs Placebo for the Treatment of Endotoxin-Induced Fever in Healthy Adult Males
A research study to determine if acetaminophen (APAP) given intravenously (IV-a liquid given through a needle into a vein in your arm) is safe and effective in controlling fever when compared to placebo.
- Trial name
- NCT00493311
- Testing
- IV Acetaminophen, Reference Standard Endotoxin (RSE)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Analgesia, Arthroscopy
Multimodal Analgesia After Shoulder Arthroscopy
This proposal aims to measure the quality of recovery and quality of pain management after shoulder surgery before and after implementation of a multimodal pain protocol.
- Conditions
- Analgesia, Arthroscopy, Shoulder Joint
- Trial name
- NCT03427775
- Testing
- multimodal perioperative pain protocol (MP3)
- Volunteers
- 252 people
- Sponsor
- University of Pennsylvania
Drug Interactions
A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers
The purpose of this research study is to determine if varying strengths of ethanol affect the drug level and safety profile of Vicodin® CR.
- Trial name
- NCT00429468
- Testing
- Vicodin® CR (extended-release hydrocodone/acetaminophen)
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott
Pain, Post Partum Depression
Vaginal Postpartum Pain Management Protocol Comparison
Untreated postpartum pain has been associated with increased risk of opioid use, postpartum depression and development of persistent pain.
- Conditions
- Pain, Post Partum Depression, Opioid Use, Breast Feeding
- Trial name
- NCT04087317
- Testing
- Paracetamol 1000 Mg Oral Tablet, Ibuprofen 400Mg Tab, Ibuprofen 400 mg
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Caesarean Section; Pain
Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.
Although it is known that parecoxib and dexketoprofen are commonly used in successful post-operative pain relief, there are very few studies that compare these two agents in their individual applications and/or combined with…
- Trial name
- NCT04847024
- Testing
- Parecoxib, Dexketoprofen
- Where
- Panama
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama
Kidney Failure, Chronic, Kidney Transplantation
Safety in Immunomodulatory Functions of Alemtuzumab (Campath) in Pediatric Kidney Transplantation Recipients
The purpose of this study is to evaluate the safety of alemtuzumab after kidney transplantation as part of a multitherapy regimen to prevent kidney graft loss and death and to avoid steroids and chronic use of calcineurin…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Immunosuppression
- Trial name
- NCT00240994
- Testing
- Alemtuzumab, Tacrolimus, Mycophenolate mofetil
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Investigate the Efficacy of Sucrose During Eye Examination
Efficacy of Oral Sucrose and Topical Anesthetics to Reduce Pain During Eye Examination for Retinopathy of Prematurity
Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants. The purpose of this study was to determine the effectiveness of local anesthetic eye drops and a pacifier, plus repeated doses of 24% sucrose, to…
- Trial name
- NCT01811979
- Testing
- Oral sucrose solution, Steril water
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Postoperative Pain, Breast Cancer
Comparison of Erector Spinae Plane Block With Serratus Anterior Plane Block for Breast Surgery
Breast cancer is by far the world's most common cancer among women and the most common cause of female death from cancer worldwide. It's worldwide incidence is 43.4 in 100.000 while in Egypt is 48.8 in 100.000.
- Trial name
- NCT03579524
- Testing
- Erector Spinae Plane Block, Serratus Anterior Plane Block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Fayoum University Hospital
Skin Laxity
Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ Treatments
This study will compare the effectiveness of two pain medications for reducing discomfort during an Ultherapy treatment.
- Trial name
- NCT01708473
- Testing
- Advil, Lortab, Ulthera System Treatment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc
Liver Fibrosis, Alpha-1 Antitrypsin Deficiency
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)
We hypothesize that individuals with Alpha-1 Antitrypsin (AAT) deficiency have ongoing liver injury which is not detected by the usual blood tests used to look at liver function.
- Conditions
- Liver Fibrosis, Alpha-1 Antitrypsin Deficiency, AAT Deficiency, AATD
- Trial name
- NCT01810458
- Testing
- Abdominal ultrasound, History and physical, Intravenous catheter
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of Florida
Toothache
The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache
This study will compare the degree of pain control provided by two techniques for persons with toothache in an emergency department.
- Trial name
- NCT00574015
- Testing
- hydrocodone/acetaminophen, bupivacaine (supraperiosteal nerve block)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albany Medical College
Post-operative Pain
Effectiveness of Cannabidiol vs. Narcotics for Post Operative Pain Control in Elective Shoulder Arthroscopic Surgery
This study is a prospective, randomized, nonblinded trial to evaluate the effectiveness of Cannabidiol (CBD) oil on post-operative pain control compared to opioid medications.
- Trial name
- CBDS (NCT05240755)
- Testing
- Cannabidiol Oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Foundation for Orthopaedic Research and Education
Healthy
Bioequivalnce Study of Loratadine / Pseudoephedrine Sulfate 10/ 240 mg Extended-Release Tablets Under Fasting Conditions
The objective of this study was to compare the single-dose relative bioavailability of Ranbaxy and Schering (Claritin-D® 24 hour) Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets, in a fully replicated…
- Trial name
- NCT00837915
- Testing
- Loratadine 10mg /Pseudoephedrine Sulfate 240 mg Extended-Release Tablets
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
The purpose of this study is to compare the level of pain control in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) to those receiving opioids in the postoperative period after endoscopic sinus surgery (ESS)…
- Trial name
- NCT03605914
- Testing
- diclofenac, Norco
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Low Back Pain, Pain
Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)
The purpose of this study is to determine if a stepped-care intervention makes pain symptoms better and reduces activity limitations because of pain. Our two primary hypotheses are that in OIF/OEF veterans with chronic pain: 1.
- Conditions
- Low Back Pain, Pain, Pain, Intractable
- Trial name
- ESCAPE (NCT00386243)
- Testing
- Cognitive behavioral therapy, Pain self-management program, Co-Analgesic Therapy
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- VA Office of Research and Development
Postoperative Pain, Opioid Use
Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer
The opioid epidemic is a considerable problem in the United States, and prescription opioids significantly contribute to the epidemic.
- Trial name
- NCT04973748
- Testing
- Surveys about pain, opioid use and depression symptoms
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Thoracic Anesthesia, Thoracotomy
Opioid Consumption After Thoracotomy and Factors Affecting Postoperative Acute Pain
Thoracic surgery operations constitute a significant portion of surgical procedures performed in hospitals. In the United States, more than 50,000 thoracic surgical procedures are performed annually, and more than 80% of these…
- Conditions
- Thoracic Anesthesia, Thoracotomy, Opioid, Postoperative Pain Management
- Trial name
- NCT07329855
- Testing
- Opioid Analgesic, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
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