Clinical trials: Acetaminophen, completed
Uterine Cervical Cancer, Upper Aerodigestive Tract Neoplasms
Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)
The results of the study will permit to set up a standardized and validated procedure of pain management authorizing medical and paramedical staff of brachytherapy department to handle pain and in this way to improve the quality…
- Trial name
- KETOCOL (NCT02439034)
- Testing
- Paracetamol, Ketoprofen
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Oscar Lambret
Gout
Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout
The purpose of this study is to assess the potential for pegloticase with methotrexate (MTX) to increase the response rate seen with pegloticase alone, and to characterize the safety, tolerability and pharmacokinetics (PK) of the…
- Trial name
- MIRROR RCT (NCT03994731)
- Testing
- Pegloticase, methotrexate, folic acid
- Where
- 60 sites in United States
- Volunteers
- 152 people
- Sponsor
- Amgen
Graft Rejection
Randomized Trial for Mixed Acute Rejection
This study is being conducted to determine how safe and effective using an immune cell (b cell) depleting therapy and/or Thymoglobulin is in patients with a kidney transplant who are experiencing certain types of rejection.
- Trial name
- NCT00771875
- Testing
- Rabbit Antithymocyte Globulin (RATG), Rituximab, Bortezomib
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Abortion, Induced, Cervical Preparation
Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial
Women having abortion procedures between 15 weeks 0 days and 23 weeks 6 days gestational age on the day of their procedure commonly have dilators placed in their cervix overnight before the abortion procedure.
- Conditions
- Abortion, Induced, Cervical Preparation, Pain
- Trial name
- GABA (NCT03080493)
- Testing
- Gabapentin 600mg, acetaminophen/codeine and ibuprofen
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of California, Davis
Transplantation, Homologous, Transplantation, Autologous
Phase 2 Study of Autologous Followed by Nonmyeloablative Allogeneic Transplantation Using TLI & ATG
To evaluate the toxicity and tolerability of this tandem autologous/allogeneic transplant approach for patients with advanced stage multiple myeloma.
- Conditions
- Transplantation, Homologous, Transplantation, Autologous, Multiple Myeloma, Blood and Marrow Transplant (BMT)
- Trial name
- NCT00899847
- Testing
- Autologous peripheral blood stem cells (auto-PBSC) transplantation, Allogeneic peripheral blood stem cells (allo-PBSC) transplantation, Filgrastim
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Acute Herpes Zoster Pain Managment
Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain.
Herpes zoster (HZ) is a painful, eruptive, viral condition results from reactivation of the latent varicella zoster virus after the primary infection.
- Trial name
- NCT06307444
- Testing
- Ultrasound-Guided Stellate Ganglion Block, T2 T3 (High Thorathic) ESP Block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Post Cesarean Pain Management
To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT02440399
- Testing
- Tramadol hydrochloride, Morphine, Paracetamol
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- HaEmek Medical Center, Israel
Sepsis and Septic Shock
Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient
The aim of this study is to evaluate the effect of Acetaminophen on the main parameters of microcirculation, on the plasmatic levels of free hemoglobin/oxidative stress markers and on the expression of PD1/Pd-L1, in pyrexial…
- Trial name
- NCT02750163
- Testing
- paracetamol
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università Politecnica delle Marche
Bariatric Surgery Candidate, Obesity, Morbid
Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.
- Trial name
- NCT02778958
- Testing
- paracetamol, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
Fibromyalgia
Randomized Controlled Trial of CES for Fibromyalgia
Given recent increasing opioid-related deaths and evidence showing against the use of opioids for non-malignant chronic pain, there is growing need for non-narcotic pain management.
- Trial name
- NCT04115033
- Testing
- Alpha-stim
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Migraine
Acetaminophen and Ibuprofen With and Without Magnesium and Primary Migraine in Childhood
Aim: The purpose of this study was to evaluate both the effects of ibuprofen and/or acetaminophen for the acute treatment of primary migraine in children in or out prophylactic treatment with magnesium.
- Trial name
- NCT01756209
- Testing
- Magnesium 400Mg, Ibuprofen 10 mg/kg, acetaminophen 15 mg/kg
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Catanzaro
Women Undergoing Oocyte Retrieval Procedures
Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure
It is unclear whether routine addition of opioids for analgesia during minor gynecological procedures is beneficial. In this single-center randomized single-blinded trial, the investigators aim to test the primary hypothesis that…
- Trial name
- NCT04933058
- Testing
- IV acetaminophen, IV fentanyl
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy
Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine
Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain.
- Trial name
- PANACE (NCT02206178)
- Testing
- N-acetylcysteine combination with acetaminophen
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Myeloma
Elotuzumab in Autologous Stem Cell Transplantation (ASCT) and Lenalidomide Maintenance for Multiple Myeloma
The purpose of this study is to explore the combination of Elotuzumab in combination with autologous stem cell transplantation and lenalidomide maintenance to see what side effects it may have and how well it works for the…
- Trial name
- NCT02655458
- Testing
- Elotuzumab, Lenalidomide, autologous PBMC reconstitution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Hearn Jay Cho
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Surgery
Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain
The purpose of this placebo controlled clinical trial is to evaluate the dose response relationship of ibuprofen in doses from 400 mg to 800 mg and paracetamol (acetaminophen)in doses from 500 mg to 1000 mg compared with…
- Trial name
- NCT00699114
- Testing
- Ibuprofen 400 mg, Ibuprofen 600 mg, Ibuprofen 800 mg
- Where
- Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Pain
A Bioequivalence Study of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) Versus Advil Dual Action Caplets (125 mg/250 mg) and Bioavailability Assessment of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) and Advil Liqui-Gels (200 mg) in Healthy Adult Subjects
The primary purpose of this study is to demonstrate the bioequivalence of new formulation Advil Dual Action (ADA) liquid filled capsules (Test) compared to the currently marketed ADA Caplet (Reference) under fasted conditions and…
- Trial name
- NCT06802185
- Testing
- ADA Liquid Filled Capsules (Test Product), ADA Caplets (Reference Product), Advil Liqui-gels (Reference Product)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- HALEON
Healthy Subjects
Pharmacokinetic Study Investigating the Extent of Paracetamol Absorption From a New Formulation of Paracetamol Compared With Panadol® Extend
This study will evaluate the pharmacokinetic profiles of experimental formulations of paracetamol.
- Trial name
- NCT01540721
- Testing
- Marketed paracetamol, Experimental paracetamol formulation
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Migraine
Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack
Patients with acute migraine attack make up the majority of patients consulting the emergency services due to headache. The aim of treatment in the emergency service is to achieve a minimum level of undesirable side effects and…
- Trial name
- NCT01730326
- Testing
- Paracetamol, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Acute Liver Failure
Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen
OBJECTIVES: I. Determine the safety and efficacy of a short course (72 hours) of intravenous acetylcysteine in patients with acute liver failure for whom no antidote or specific treatment is available.
- Trial name
- NCT00004467
- Testing
- N-acetylcysteine (NAC)
- Where
- 25 sites in United States
- Volunteers
- 173 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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