Clinical trials: Acetaminophen, completed
Childhood Idiopathic Nephrotic Syndrome
A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Idiopathic Nephrotic Syndrome
This open-label, randomized multicenter study is to assess the efficacy, safety, and pharmacokinetics (PK)/pharmacodynamics (PD) of obinutuzumab compared with mycophenolate mofetil (MMF) in children and young adults (aged >= 2-25…
- Trial name
- INShore (NCT05627557)
- Testing
- Obinutuzumab, MMF, Prednisone
- Where
- 35 sites in United States, Belgium and 7 more
- Volunteers
- 85 people
- Sponsor
- Hoffmann-La Roche
Pain
Disposition of Intravenous Paracetamol in Young Women
Compared to early postpartum (10-15 weeks) observations, paracetamol clearance was significantly higher (21.1 vs 11.7 l.h-1, + 80 %) at delivery.
- Trial name
- NCT02590900
- Testing
- intravenous paracetamol (acetaminophen)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Pain
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Some patients have respiratory depression (decreased breaths per minute) after surgery. Acetaminophen, an FDA approved pain medication, may prevent this problem.
- Trial name
- NCT02156154
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Wounds and Injuries, Rib Fractures
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma.
- Trial name
- NCT02432456
- Testing
- Ketamine, Intercostal Nerve Block, Acetaminophen
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Medical College of Wisconsin
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Gall Stone Disease
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
Comparison of intraoperative infusion of lidocaine and esmolol in the postoperative requirement of opioid for postoperative pain management after laparoscopic cholecystectomy to decrease opioid related side effects and enhance…
- Trial name
- NCT02327923
- Testing
- Lidocaine, Esmolol, Paracetamol
- Where
- Nepal
- Volunteers
- 90 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Acetaminophen Toxicity
Treatment of Acetaminophen Toxicity With N-acetylcysteine
Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.
- Trial name
- NCT00725179
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Akron Children's Hospital
Cholecystectomy, Pain, Postoperative
Nonopioid Analgesics and Cholecystectomy
The goal of this clinical trial is to evaluate the effect of the addition of nefopam to a multimodal analgesic regimen consisting of ketoprofen and paracetamol during sevoflurane- dexmedetomidine-based anesthesia on postoperative…
- Conditions
- Cholecystectomy, Pain, Postoperative, Opioid Use
- Trial name
- NCT04622813
- Testing
- nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol
- Where
- Lebanon
- Volunteers
- 90 people
- Sponsor
- American University of Beirut Medical Center
Borderline Personality Disorder
Acetaminophen and Social Processes
Recent research has identified heightened sensitivity to social rejection as a core feature of BPD. Rejection sensitivity can trigger the aggressive, impulsive, and self-injurious behaviors characteristic of the disorder.
- Trial name
- NCT02108990
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ohio State University
Breast Cancer Female, Joint Pain
Evaluation of the Efficacy of a Homeopathic Protocol in Patients With Non-metastatic Breast Cancer
Interventional, randomised, prospective, monocentric study
- Trial name
- ARHOMA2 (NCT04408560)
- Testing
- Rhus toxicodendron 9 CH + Ruta graveolens 5 CH (Homeopathic Granules), paracetamol (drug analgesic class1)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Institut Jean-Godinot
Postoperative Pain
Elective Total Abdominal Hysterectomy With Preoperative Analgesia Intravenous Paracetamol Versus Placebo
The study aim to study to evaluate whether IV paracetamol reduces morphine use after TAH. Primary objective was to compare postoperative morphine consumption between the IV paracetamol and control groups.
- Trial name
- NCT07368790
- Testing
- Paracetamol
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Hepatotoxicity
Acetaminophen-induced Hepatotoxicity in Chronic Alcohol Abusers
It is widely believed that people who abuse alcohol can sustain a liver injury after taking doses of acetaminophen just above the recommended maximum dose.
- Trial name
- NCT00137059
- Testing
- acetaminophen sustained-release
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Marco L.A. Sivilotti
Colorectal Cancer
Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding…
- Trial name
- NCT06042816
- Testing
- Free-opioid anesthesia, opioid anesthesia
- Where
- Vietnam
- Volunteers
- 49 people
- Sponsor
- Vietnam Military Medical University
Migraine With and Without Aura
Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With Nausea
This proof-of-concept study compares side-by-side low-dose naltrexone and acetaminophen combination to sumatriptan in the acute treatment of migraine.
- Trial name
- NCT03185143
- Testing
- Naltrexone and Acetaminophen Combination, Sumatriptan 100 mg
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Allodynic Therapeutics, Inc
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Anesthesia
Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Several studies demonstrated the effectiveness of OFA in patients undergoing non-cardiac surgery. Preoperative use of Cox inhibitors, GABA analogues and acetaminophen have been shown to decrease use of opioids postoperatively .
- Trial name
- NCT04648540
- Testing
- Dexmedetomidine 0.5 mic/kg/h, Fentanyl 1 mic/kg/hr
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction
The Copenhagen Analgesic Study
Fundamental aspects of reproductive function are established in fetal life and there is a present increased awareness of the potential effects of fetal exposures on reproductive health of offspring.
- Trial name
- COPANA (NCT04369222)
- Testing
- Observational
- Where
- 2 sites in Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Recurrence of Febrile Seizure
Antipyretics for Preventing Recurrences of Febrile Seizures
We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic…
- Trial name
- NCT00568217
- Testing
- Diclofenac, Paracetamol, Ibuprofen
- Where
- Finland
- Volunteers
- 231 people
- Sponsor
- University of Oulu
Analgesia
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal…
- Trial name
- NCT03907176
- Testing
- HTX-011, Luer lock applicator, Ibuprofen
- Where
- 30 sites in United States
- Volunteers
- 209 people
- Sponsor
- Heron Therapeutics
Pain and Curettage
Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage
Patients frequently experience pain from moderate to severe during gynecologic procedures. This study is a prospective, randomized, placebo-controlled trial and aimed to investigate the analgesic efficacy of preoperative oral…
- Trial name
- NCT01993589
- Testing
- comparison of pain relievers during curattage, comparison of pain relievers
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
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