Clinical trials: Acetaminophen, completed
Blood Cancer, Leukemia
Allogeneic Transplantation From Related Haploidentical Donors
The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+ selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative regimen of total lymphoid irradiation (TLI)…
- Conditions
- Blood Cancer, Leukemia, Graft Versus Host Disease, Malignancy
- Trial name
- NCT00185692
- Testing
- non-myeloablative hematopoietic cell transplantation, Anti-Thymocyte Globulin, Cyclosporine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
Dysmenorrhea
A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea
The purpose of this study is to compare the maximum single dose of Aleve® (two tablets, equivalent to 440 mg of naproxen sodium) to the maximum single dose of Tylenol Extra Strength (two caplets, equivalent to 1000 mg of…
- Trial name
- NCT03448536
- Testing
- Naproxen Sodium, (Aleve, BAY117031), Acetaminophen (Tylenol Extra Strength)
- Where
- 8 sites in United States
- Volunteers
- 201 people
- Sponsor
- Bayer
Adenotonsillitis, Tonsillitis
Analgesic Effect of IV Acetaminophen in Tonsillectomies
Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile…
- Trial name
- NCT01691690
- Testing
- Acetaminophen (paracetamol), Normal Saline Flush, Midazolam
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Injection Site Irritation
The Prevention of Pain Associated With Rocuronium Injection
The purpose of this study is to determine whether efficacy of different doses of lidocain and acetaminophen for the prevention of rocuronium injection pain and frequency of withdrawal movements during the general anesthesia…
- Trial name
- NCT02524743
- Testing
- acetaminophen, Lidocaine
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Osteo Arthritis Knee
Evaluation of the Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis
This study is designed as a randomized clinical trial that will be conducted in Hazrat Rasool Akram Hospital in Tehran. Patients with knee osteoarthritis were selected based on the study entry criteria and written consent was…
- Trial name
- NCT06088706
- Testing
- Intra-articular injection of ozone
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Ahmad Nazari
Relapsing-remitting Multiple Sclerosis
Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA
Primary Objective: To assess the distribution of IARs by severity grade when LEMTRADA is administered to RRMS patients who will be medicated according to specified algorithm designed to manage infusion associated reactions.
- Trial name
- EMERALD (NCT02205489)
- Testing
- Alemtuzumab GZ402673, cetirizine, ranitidine
- Where
- 20 sites in Belgium, France and 2 more
- Volunteers
- 58 people
- Sponsor
- Genzyme, a Sanofi Company
Metabolic Side Effects of Drugs
Studies of Sulfur Metabolism in Humans
The study test whether the NSAID allosteric site of human sulfotransferase 1A1 (SULT1A1) is operative in humans. The study will test the effects of mefenamic acid (MEF) on the sulfonation of acetaminophen (APAP, a SULT1A1…
- Trial name
- NCT03383133
- Testing
- SULT Allosteric Inhibition
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Albert Einstein College of Medicine
Dysmenorrhea
Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea
Patients presented with primary dysmenorrhea composed the study population. One gram paracetamol and 100 mg tramadol in 100 ml saline with a slow infusion were compared in ceasing dysmenorrhea in the emergency department
- Trial name
- NCT03509740
- Testing
- tramadol, paracetamol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Supratentorial Neoplasms
Opioid Free VS Opioid Anesthesia for Craniotomies
Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia…
- Trial name
- NCT04941040
- Testing
- Opioid free anesthetics, Opioid Anesthetics
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Meniscus Disorder, Narcotic Use
Nonopioid Analgesia After Arthroscopic Meniscus Surgery
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of arthroscopic meniscus surgery: a treatment group given…
- Trial name
- NCT03820193
- Testing
- Celecoxib, Hydrocodon/Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Moderate Alcohol Consumption (1-3 Drinks Per Day)
Effects of Therapeutic Doses of Acetaminophen in Moderate Drinkers
The study objective was to evaluate the safety of ten consecutive days of therapeutic acetaminophen dosing in moderate alcohol consumers.
- Trial name
- NCT00400621
- Testing
- acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Temporomandibular Disorder
Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain
Temporomandibular disorders (TMDs) are one of the most common muco-skeletal disorders, seen in the dental clinics. Many factors work together to initiate or aggravate the condition, so it is a multifactorial disorder.
- Trial name
- NCT04066426
- Testing
- naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Yuzuncu Yil University
Cesarean Section, Postoperative Pain
TAP vs QLB in Patients After Cesarean Delivery
Comparison of two types of analgesia after cesarean section All patients will be anesthetized with spinal technique. Ultrasound-guided transversus abdominis plane or quadratus lumborum block to treat postoperative pain.
- Trial name
- NCT03404908
- Testing
- TAP (transversus abdominis plane block), QL (quadratus lumborum block), Ropivacaine
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Lublin
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Brain Injuries
The Effect of Paracetamol on Brain Temperature
The main objective of this study is to compare the effect of intravenous paracetamol administration on mean brain temperature (measured between H0 and H6) in patients with cerebral hyperthermia versus placebo.
- Trial name
- NEUROTHERM (NCT03648021)
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Diverticulitis
Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics
Patients with mild acute diverticulitis (modified Neff 0 grade), following the inclusion criteria and giving informed consent, will be included in the study protocol and will be randomly assigned to one of the treatment arms…
- Trial name
- NCT02785549
- Testing
- Ibuprofen, Acetaminophen, Amoxicillin/clavulanic acid
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- Corporacion Parc Tauli
Post Operative Pain Management
A Novel Usage of Transdermal Scopolamine in Reducing Narcotic Usage in Outpatient Hand Surgery
The investigators will examine and analyze opioid narcotic usage patterns by requesting patients keep a two week log of their opioid usage following outpatient hand surgery with a standard analgesic regimen consisting of an…
- Trial name
- NCT04008264
- Testing
- Scopolamine Patch (Transderm V)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Alexander M Spiess, MD
To Control Pain After Third Molar Surgery
Efficacy of Preoperative Administration of Paracetamol-codeine on Pain Following Impacted Mandibular Third Molar Surgery
Objectives: The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute post-operative pain after the surgical removal of an impacted…
- Trial name
- NCT03049878
- Testing
- Paracetamol Codeine
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
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