Clinical trials: Acetaminophen, completed
Diabetes
Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners
The purpose of this study is to collect data that will help researchers better understand the various causes of obesity and diabetes; particularly to understand how consumption of NCASs affects the way the body uses nutrients.
- Trial name
- ISTAR (NCT02835859)
- Testing
- Dietary: saccharin, Estimate glucose absorptions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Gastrointestinal Mucosal Damage
Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics
This study evaluated the effect of oral fast-dissolving formulations of paracetamol and ibuprofen on the lining of the stomach and duodenum (gastrointestinal mucosa).
- Trial name
- NCT01822665
- Testing
- Ibuprofen, Paracetamol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sepsis, Acetaminophen
Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients
This is a randomized double-blind controlled study with the primary aim of scientifically evaluating the potential effects of paracetamol and ibuprofen in the management of sepsis by comparing their fever-reducing efficacy in…
- Conditions
- Sepsis, Acetaminophen, Fever, Ibuprofen
- Trial name
- NCT06061575
- Testing
- Acetaminophen, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain, Abdominoplasty Surgery
Cohort 2 (Abdominoplasty) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)
Cohort 2 (subjects undergoing abdominoplasty) of a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing different surgical procedures See also…
- Conditions
- Postoperative Pain, Abdominoplasty Surgery, Multimodal Analgesia
- Trial name
- AMAZE (NCT06109428)
- Testing
- MMA regimen, ZYNRELEF kit components for administration, HTX-011
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Heron Therapeutics
Postoperative Pain
Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair
The aim of the study is to determine wether continuous wound infusion with local anaesthetic plus a single dose intravenous morphine is non-inferior to postoperative analgesia provided with continuous thoracic epidural infusion…
- Trial name
- APERIVIP (NCT02677532)
- Testing
- Paracetamol, Levobupivacaine wound infiltration, Levobupivacaine epidural bolus
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- University of Genova
Osteoarthritis
An Effectiveness and Safety Study of Two Doses of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee
The purpose of this study is to determine the safety and effectiveness of 650 mg and 1300 mg acetaminophen extended release given three times a day for the relief of signs and symptoms of osteoarthritis of the hip or knee for a…
- Trial name
- NCT00240786
- Testing
- acetaminophen extended release
- Volunteers
- 483 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Drug Mechanism, Healthy
Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique
The main objective is to assess whether a novel electrochemical tool is reliable in detecting concentration of paracetamol in fingerprick- , saline-, urine-, and serum samples. We will recruit 12 healthy volunteers aged 18-45.
- Trial name
- NCT04690673
- Testing
- Paracetamol, Paracetamol concentration measurements and lipidomic assessment
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johanna Kujala
Flu
Efficacy and Safety of Paracetamol, Chlorpheniramine and Phenylephrine in the Treatment of Common Cold and Flu Syndrome
The aim of this study is to evaluate the efficacy and safety of a fixed combination of paracetamol, phenylephrine and chlorpheniramine in symptomatic treatment of common cold and flu-like illness in adults in a randomized…
- Trial name
- NCT01389518
- Testing
- Active
- Volunteers
- 146 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy
Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen Oral Suspension
This study was carried out in the Clinical and Analytical Unit of the Pharmacology and Toxicology Department of the Faculty of Medicine of the Autonomous University of Nuevo León, in order to compare the bioavailability (Cmax…
- Trial name
- NCT05428293
- Testing
- A1: Ibuprofen/Acetaminophen Fixed dose combination oral suspension (Laboratorios Silanes S.A. de C.V.), A2: Ibuprofen (Advil®, Pfizer S.A. de C.V.), A3: Acetaminophen (Tylenol®, from Janssen-Cilag, S.A. de C.V.)
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Symptomatic Uterine Fibroids and Adenomyosis
Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure
The uterine fibroid embolization (UFE) procedure is a treatment option for abnormal heavy menstrual bleeding and/or bulk symptoms associated with uterine fibroids and adenomyosis.
- Trial name
- NCT02227316
- Testing
- IV Ibuprofen, IV Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Overweight, Obesity
A Study to Measure Stomach Emptying in Overweight Non-diabetic and Diabetic Participants Using Tirzepatide
The purpose of this study is to learn more about how tirzepatide affects stomach emptying in overweight/very overweight participants. Participants include those without diabetes and those with type 2 diabetes.
- Conditions
- Overweight, Obesity, Diabetes Mellitus, Type 2
- Trial name
- NCT04407234
- Testing
- Tirzepatide, Acetaminophen
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Eli Lilly and Company
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Analgesia
Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block
The aim of this study is to study the analgesic efficacy of a continuous infusion of local anaesthetics for interscalene brachial plexus block after major shoulder surgery in the setting of multimodal analgesia, in order to…
- Trial name
- BIGKIS (NCT04394130)
- Testing
- ropivacaine 0.2%
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Eric Albrecht
Fever, Headache Disorders
Pharmacokinetic Study to Compare Two Formulations of Paracetamol
A pharmacokinetic study in healthy volunteers comparing two formulations of paracetamol fast release in fasted state.
- Conditions
- Fever, Headache Disorders, Pain
- Trial name
- NCT01767428
- Testing
- Paracetamol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dementia, Alzheimer Disease, Pain
Pain Management and Behavioral Outcomes in Patients With Dementia
Dementia illness often co-exists with painful medical conditions associated with aging (e.g., degenerative joint disease, osteoarthritis, skin ulcers, back pain, headaches, cancer, or angina).
- Conditions
- Dementia, Alzheimer Disease, Pain, Behavior, Agitation
- Trial name
- NCT00012857
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- US Department of Veterans Affairs
Hip Pain Chronic
Efficacy of Multimodal Analgesia Following Hip Arthroscopy
The purpose of the full study is to determine whether multimodal analgesia for hip arthroscopy will reduce post-operative pain scores, narcotic consumption and hospital length-of-stay.
- Trial name
- NCT03351439
- Testing
- Zopiclone, Gabapentin, Celebrex
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Post-op Pain
PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV acetaminophen
- Trial name
- KHEA (NCT02244619)
- Testing
- Oral acetaminophen, IV acetaminophen
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Kettering Health Network
Respiratory Insufficiency
Incidence Of Hemidiaphragmatic Paralysis After Usg Guided Low Dose Interscalene Brachial Plexus Block
to put a catheter in interscalene brachial plexus USG guided and give a bolus of drug followed by 24 hours continous infusion of drug
- Trial name
- NCT03081728
- Testing
- Interscalene Block with Ropivacaine Hcl 0.2% Inj Vil 10Ml, IV diclofenac and IV paracetamol
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Low Back Pain
Stratified Primary Care for Low Back Pain
The SPLIT project evaluates the implementation of a stratified model of care for people with low back pain patients who consulted primary care.This involves evaluating the process of implementation as well as patient level…
- Trial name
- SPLIT (NCT04046874)
- Testing
- Usual Care, SPLIT Stratified Model of Care
- Where
- Portugal
- Volunteers
- 175 people
- Sponsor
- Instituto Politécnico de Setúbal
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