Clinical trials: Acetaminophen, completed
Pain, Acute, Hip Arthropathy
Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty
Multimodal pain management is essential for recovery after surgery, aiming to target different pain mechanisms to minimize opioid usage and opioid-related adverse effects.
- Conditions
- Pain, Acute, Hip Arthropathy, Analgesia, Postoperative Pain
- Trial name
- RECIPE (NCT04123873)
- Testing
- Paracetamol, Ibuprofen, Dexamethasone
- Where
- 7 sites in Denmark
- Volunteers
- 1,060 people
- Sponsor
- Naestved Hospital
Pain
Drug Interactions Between Paracetamol and Setrons in Pain Management
The aim of this study is to demonstrate that the association paracetamol / ondansetron is not as effective as the association paracetamol / droperidol in the treatment of pain in children following tonsillectomy.
- Trial name
- PARATRON (NCT01432977)
- Testing
- paracetamol /droperidol, paracetamol / ondansetron
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Limoges
Acute Low Back Pain
A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Acetaminophen and Tramadol Combination BID Versus Placebo for the Treatment of Acute Low Back Pain
A multi-center placebo controlled, double-blind, trial comparing the analgesic efficacy and safety of Acetram Contramid® BID versus placebo for the treatment of acute low back pain in patients between 18 and 80 yrs of age.
- Trial name
- NCT00643383
- Testing
- Combination drug (Acetaminophen + Tramadol)
- Where
- 38 sites in United States, Canada
- Volunteers
- 277 people
- Sponsor
- Labopharm Inc.
Acute Pancreatitis
Evidence Based Management of Acute Biliary Pancreatitis
This study aims to assess the outcome of standardized evidence-based care to all patients with acute biliary pancreatitis treated at surgery department, Zagazig University hospitals during the period from may, 2017 to may 2019.
- Trial name
- NCT04615702
- Testing
- serum lipase or amylase, ultrasound, CT
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy
Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients
Background: Adenotonsillectomy is one of the most common pediatric surgeries and is often complicated by postoperative emergence agitation (POEA), a short-lived but distressing state of confusion and restlessness after…
- Trial name
- POEA (NCT07433231)
- Testing
- Magnesium sulfate (MgSO4) infusion, Propofol bolus, Ketamine bolus
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ayfer Kaya Gök
Delayed Onset Muscle Soreness
A Study Comparing the Efficacy and Safety of Orally Administered Ibuprofen and Placebo in Delayed Onset Muscle Soreness
The hypotheses to be tested are: Efficacy: Ibuprofen will be more effective than the Placebo in relieving muscle pain/soreness over 48 hour post-dosing with study medication.
- Trial name
- DOMS (NCT02113566)
- Testing
- Acetaminophen 1000mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jean Brown Research
Pain, Postoperative, Analgesia
Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
The aim of the study is to compare the efficacy of the pre-operative administration of Paracetamol and placebo in reducing postoperative pain after routine dental treatment in children.
- Trial name
- NCT02393339
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Fibromyalgia
Feasibility Study: fMRI Evaluation of Auricular PENFS for Fibromyalgia
Given recent increasing opioid-related deaths and evidence showing against the use of opioids for non-malignant chronic pain, there is growing need for non-narcotic pain management.
- Trial name
- fMRI (NCT03008837)
- Testing
- Military Field Stimulator, Standard Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Office of Research and Development
Migraine Disorders
Valproate Versus Topiramate in Migraine
Investigators aim to compare the effect of valproate versus topiramate in migraine by assessing the reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency…
- Trial name
- NCT06248931
- Testing
- Valproic acid, Topiramate 50 MG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University
Pain
Bioequivalence Study for Mejoral 500 Product
This will be a monocentric, single blinded, randomized, single-dose, two-periods, two-sequence, crossover bioequivalence study of two oral formulations in healthy participants under fasting conditions.
- Trial name
- NCT02504775
- Testing
- Mejoral® 500 Tablets, Tylenol® Caplets
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Upper Respiratory Tract Infection, Nasal Congestion
Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu
The study is a clinical evaluation of an over the counter (OTC) combination product containing paracetamol (500 mg), dimethindene maleate (1 mg), phenylephrine hydrochloride (10 mg) compared to paracetamol (500 mg) alone in the…
- Conditions
- Upper Respiratory Tract Infection, Nasal Congestion, Rhinorrhea, Sneezing
- Trial name
- NCT01448057
- Testing
- Paracetamol (500 mg)/dimethindene maleate (1 mg)/ phenylephrine hydrochloride (10 mg) tablets, Paracetamol (500 mg) tablets
- Where
- 6 sites in Brazil
- Volunteers
- 341 people
- Sponsor
- Novartis
Knee Osteoarthritis
To Assess the Lanconone® (E-OA-07) Efficacy in Physical Activity-related Pain- LEAP Study
The current study is designed to assess the pain relieving effect of 4-weeks ingestion of this commercialized dietary supplement (Lanconone®, Enovate Biolife, LLC, 1000 mg twice per day) in mild to moderate OA subjects.
- Trial name
- LEAP (NCT03262805)
- Testing
- Lanconone
- Where
- 3 sites in India
- Volunteers
- 73 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Healthy
Bioavailability Study of SPARC001(Study 1) in Healthy Adult Volunteers
The objective of the study is to determine the relative bioavailability, safety and tolerability of SPARC001 and Reference001 in healthy, adult, male and female subjects
- Trial name
- NCT02991222
- Testing
- SPARC001 type I, SPARC001 type II, Reference001 type I
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sun Pharma Advanced Research Company Limited
Thyroidectomy, Post-operative Swallowing Disorders
Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroidectomy
The scientific interest of this study is to improve post-operative comfort in patients after thyroid surgery using simple, inexpensive techniques.
- Trial name
- DEGLUTHYR (NCT02855866)
- Testing
- thyroidectomy, cryotherapy, cortisone aerosol
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Post Operative Dental Pain
Study of Acetaminophen (ACM) in Post-operative Dental Pain
This is a Dental Pain Study which will evaluate the analgesic onset, efficacy and safety of 1000 mg acetaminophen as two Test acetaminophen 500 mg tablets, compared with commercial products of acetaminophen 1000 mg administered…
- Trial name
- NCT02735122
- Testing
- acetaminophen Tablet, acetaminophen Caplet, ibuprofen Liquid-filled capsule
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Common Cold
To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers
This clinical study will be conducted to characterize the gastrointestinal transit of two multi-symptoms formulations by inclusion of a radiolabel marker.
- Trial name
- NCT03415243
- Testing
- Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg, Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine, Pain
THE EFFECTS OF KINESIO®TAPING IN PATIENTS WITH MIGRAINE
In patients with migraine, neck pain and trigger points in the neck muscles are common in clinical practice. This study was to investigate whether kinesiotaping applied to the cervical muscles has a clinical effect on pressure…
- Trial name
- NCT04185714
- Testing
- Kinesiotaping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Acute Pain
Effect of Early Pain Management at Triage on Opioid Consumption
introduction: Pain remains one of the most common reasons of emergency department admission. Opioids are overprescribed in emergency departments to treat severe pain.
- Trial name
- NCT03243006
- Testing
- Paracetamol, Tramadol/Paracetamol combination
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
To Control Pain After Third Molar Surgery
Efficacy of Preoperative Administration of Paracetamol-codeine on Pain Following Impacted Mandibular Third Molar Surgery
Objectives: The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute post-operative pain after the surgical removal of an impacted…
- Trial name
- NCT03049878
- Testing
- Paracetamol Codeine
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Osteoarthritis
Time of Intravenous Acetaminophen Administration
The purpose of the study is to examine the effects of timing of administration of intravenous (IV) acetaminophen and how timing relates to analgesic efficacy as measured by postoperative pain scores.
- Trial name
- TIAA (NCT01699815)
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Duke University
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