Clinical trials: Acetaminophen, completed
Post Operative Pain
Ultrasound-guided Transversus Abdominis Plane Block After Hysterectomy
In this randomized, controlled, observer-blinded study we plan to evaluate ultrasound-guided transversus abdominis plane (TAP) block for postoperative pain management in patients undergoing abdominal hysterectomy.
- Trial name
- TAP (NCT01153503)
- Testing
- TAP block
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Healthy Subjects
Evaluation of Apraglutide on Gastric Emptying
The primary objective is to assess the effect of apraglutide on gastric emptying of liquids in healthy subjects, as measured by the PK of acetaminophen mixed with a liquid meal.
- Trial name
- NCT05995704
- Testing
- Apraglutide, Acetaminophen
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VectivBio AG
Pain, Postoperative, Lung Diseases
Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection
This is a single center, single surgeon, prospective, randomized trial examining the addition of Cryo Nerve Block during robot assisted thoracoscopic anatomic lung resection surgery
- Trial name
- NCT05144828
- Testing
- Intercostal Nerve Cryoablation, Patient-controlled analgesia (PCA)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical College of Wisconsin
Transgender Persons
Effect of Testosterone Treatment on Drug Metabolism and Transport
This project will evaluate the effect of gender-affirming testosterone treatment on how other medications are processed by the body.
- Trial name
- NCT05116293
- Testing
- Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Nail Diseases, Nail Abnormality
Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia
The purpose of this study is to assess the safety and efficacy of ropivacaine and hydrocodone for nail-procedure associated pain management.
- Trial name
- NCT05544734
- Testing
- Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Metastatic Cancer, Pain
Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer
RATIONALE: Morphine may reduce pain in patients who have undergone radiofrequency ablation to remove bone metastases. PURPOSE: This phase II trial is studying how well morphine works after radiofrequency ablation of painful bone…
- Conditions
- Metastatic Cancer, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- MEDOR (NCT00712712)
- Testing
- Acetaminophen, Morphine Sulfate, Questionnaire administration
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Institut Bergonié
Analgesic, Enhanced Recovery After Surgery
Efficacy and Safety of Acetaminophen in Postoperative Pain Management of Infants
Pain will bring early and long-term adverse reactions to infants. The investigators need to pay attention to whether there is pain in infants after surgery.
- Conditions
- Analgesic, Enhanced Recovery After Surgery, Postoperative Pain, Infant ALL
- Trial name
- NCT05564819
- Testing
- Acetaminophen, Sterilized water
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Nanjing Children's Hospital
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Diabetes
Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners
The purpose of this study is to collect data that will help researchers better understand the various causes of obesity and diabetes; particularly to understand how consumption of NCASs affects the way the body uses nutrients.
- Trial name
- ISTAR (NCT02835859)
- Testing
- Dietary: saccharin, Estimate glucose absorptions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Analgesia
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal…
- Trial name
- NCT03907176
- Testing
- HTX-011, Luer lock applicator, Ibuprofen
- Where
- 30 sites in United States
- Volunteers
- 209 people
- Sponsor
- Heron Therapeutics
Healthy
MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers
Elderly people often suffer from chronic pathologies and they are given polypharmacy. In case of swallowing problems, the drugs are crushed and mixed in food, which alters the taste of food and is a cause of anorexia and…
- Trial name
- MELA (NCT02570581)
- Testing
- Jelly with:Paracetamol, Jelly with Furosemide, Jelly with Levothyroxine sodium salt
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Craniosynostoses, Pain, Postoperative
Scalp Block Decreases Pain and Side Effects
Postoperative analgesia after corrective surgery of paediatric craniosynostosis is crucial in term of short and long-term outcomes.
- Trial name
- NCT04133467
- Testing
- scalp block
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Melanoma (Skin)
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003346
- Testing
- acetaminophen, acetylcysteine, carmustine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Low Back Pain, Postural
Effectiveness of Frog Leg Technique in Management of Low Back Pain Due to Lumbar Lordosis
Condition in which lumbar region experiences stress or extra weight and is arched to point of muscle pain or spasms is called Lumbar hyperlordosis.The study findings compared the effectiveness of frog leg technique and standard…
- Trial name
- NCT05945056
- Testing
- Frog Leg Exercise, Electrotherapy(Transcutaneous Electrical Nerve Stimulator), Exercise Therapy
- Volunteers
- 28 people
- Sponsor
- Health Education Research Foundation (HERF)
Oxidative Stress
Metabolic Effects of Chemical Interactions in Toxicity
This pilot study tests the feasibility of using GSH redox state and high resolution proton NMR spectroscopy (1H-NMR) to detect metabolic changes due to acetominophen and sulfur amino acid deficiency.
- Trial name
- NCT00253773
- Testing
- acetominophen, sulfer amino acids; cysteine and methionine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Drug Mechanism, Healthy
Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique
The main objective is to assess whether a novel electrochemical tool is reliable in detecting concentration of paracetamol in fingerprick- , saline-, urine-, and serum samples. We will recruit 12 healthy volunteers aged 18-45.
- Trial name
- NCT04690673
- Testing
- Paracetamol, Paracetamol concentration measurements and lipidomic assessment
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johanna Kujala
Postoperative Pain
Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
The purpose of this study is to evaluate patients with emergency pain and a sore (infected) tooth to determine if immediate root canal therapy is better at reducing pain, when compared to initial treatment with antibiotic and…
- Trial name
- NCT01870973
- Testing
- root canal treatment, anesthesia, pain medications, and antibiotic, no root canal treatment, anesthesia, pain medications, and antibiotic
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Ohio State University
Lupus Erythematosus, Systemic
A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus
This is a Phase II/III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of rituximab compared with placebo when combined with a single stable background immunosuppressive…
- Trial name
- EXPLORER (NCT00137969)
- Testing
- Rituximab, Prednisone, Acetaminophen
- Where
- 65 sites in United States, Canada
- Volunteers
- 262 people
- Sponsor
- Genentech, Inc.
Rotator Cuff Tear
Nonopioid Analgesia After Rotator Cuff Repair
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of rotator cuff repair: a treatment group given a…
- Trial name
- NCT03818919
- Testing
- Celecoxib, Ketorolac, Gabapentin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vertebral Subluxation, Spine Disease
Erector Spinae Block vs Morphine in Vertebral Fixation
The study aims to shed light about the potential role of Erector Spinae Block in the management of postoperative pain following vertebral fixation surgery via posterior approach.
- Conditions
- Vertebral Subluxation, Spine Disease, Spondylolisthesis
- Trial name
- ATLANTE (NCT04729049)
- Testing
- Erector Spinae plane Block, Patient controlled analgesia with intravenous morphine
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- AUSL Romagna Rimini
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