Clinical trials: Acetaminophen, completed
Acute Pain, Headache
Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care
The investigators will assess whether behavioral science-based interventions can "nudge" providers towards more evidence-based care for patients with acute non-cancer pain.
- Conditions
- Acute Pain, Headache, Musculoskeletal Pain
- Trial name
- NCT03537573
- Testing
- Usual Care/Guideline, Opioid Justification, Provider Comparison
- Where
- United States
- Volunteers
- 22,616 people
- Sponsor
- University of Pittsburgh
Hypersenstivity Pneumonitis, ILD
Rituximab Therapy in Patients With Treatment Refractory Hypersenstivity Pneumonitis
Hypersensitivity pneumonitis (HP) presents with a highly variable clinical course, and Traditional treatment involves systemic corticosteroids in conjunction with strict avoidance of the offending antigen.
- Trial name
- NCT07035561
- Testing
- Rituximab (Mabthera)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Shereen Medhat Mohammed Elsayed Nassar
Functional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome
Targeted Food Elimination for Treatment of Functional Gastrointestinal Diseases in Children
Recurrent Abdominal Pain (RAP) in children is common and causes significant functional impairment and poor quality of life. Lifestyle factors such as diet, anxiety, and stress are important triggers of abdominal pains, but there…
- Conditions
- Functional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome, Abdominal Pain (AP)
- Trial name
- FGID (NCT02565355)
- Testing
- Dietary Exclusion, Standard Treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Pain, Opioid Use
Improving Post-Operative Pain and Recovery in Gynecologic Surgery
This is a clinical investigation to determine the efficacy of rectal versus intravenous acetaminophen in patients undergoing a minimally invasive hysterectomy.
- Conditions
- Postoperative Pain, Opioid Use, Acetaminophen
- Trial name
- NCT04175509
- Testing
- Rectal acetaminophen, Intravenous acetaminophen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aultman Health Foundation
Migraine, Head Pain
A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache
The purpose of this study is to evaluate the effectiveness and safety of tramadol HCl/acetaminophen as a pain medication compared with placebo in the treatment of acute pain from a migraine headache.
- Conditions
- Migraine, Head Pain, Headache
- Trial name
- NCT00297375
- Testing
- tramadol HCl/acetaminophen
- Volunteers
- 375 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Lumbar Osteoarthritis, Spondylosis
Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Patients undergoing spine surgery often have considerable pain post-operatively and frequently require opioid medication (Percocet, Norco, oxycodone, morphine, etc.) to control their pain postoperatively.
- Conditions
- Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
- Trial name
- NCT02700451
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Disc Herniation
Tramadol vs.Tramadol With Paracetamol
This study focused on to determine postoperative analgesic efficacy of tramadol compared to tramadol with addition of paracetamol after a lumbar disc surgery.
- Trial name
- NCT03482492
- Testing
- Tramadol, Paracetamol
- Volunteers
- 60 people
- Sponsor
- Yeditepe University Hospital
Pain Management, Posterior Spinal Fusion
Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery
This study consisted of a randomized controlled trial designed to evaluate a Multimodal Analgesia (MMA) Protocol on patients undergoing Posterior Spinal Fusion.
- Trial name
- NCT05413902
- Testing
- Toradol, Morphine, Orphenadrine
- Where
- Puerto Rico
- Volunteers
- 100 people
- Sponsor
- University of Puerto Rico
Pain, Postoperative
Effect of Fu's Subcutaneous Needling on Postoperative Acute Pain in Patients With Lumbar Spine Surgery.
The goal of this clinical trial is to evaluate Fu's Subcutaneous Needling (FSN) in postoperative pain in patients with Lumbar Spine Surgery (LSS).
- Trial name
- NCT05572931
- Testing
- Fu's Subcutaneous Needling(FSN), fine acupuncture needle
- Where
- Taiwan
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Primary Sjögren Syndrome
Pilot Trial of Ustekinumab for Primary Sjögren's Syndrome
This pilot study will make a preliminary determination of the safety of ustekinumab in patients with Primary Sjogren's Syndrome (PSS) and assess the response of systemic measures of inflammation (biomarkers).
- Trial name
- NCT04093531
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Brain and Central Nervous System Tumors, Intraocular Melanoma
Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00445965
- Testing
- DNA analysis, immunologic technique, pharmacological study
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Impacted Third Molar Tooth, Pain, Acute
Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction
This research study will evaluate inter-individual variability in the analgesic response to the non-steroidal anti-inflammatory drug (NSAID) ibuprofen after third molar extraction surgery.
- Trial name
- NCT03893175
- Testing
- Ibuprofen, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Pennsylvania
Healthy
Bioequivalence Study of Tramadol Hydrochloride /Paracetamol Tablets Versus Ultracet Tablets
The sponsor, Pfizer has developed a formulation of tramadol hydrochloride/ paracetamol 37.5 mg/ 325 mg (test drug) as a generic alternative to the reference listed product Ultracet®.
- Trial name
- NCT03803371
- Testing
- Ultracet Tablets, Tramadol hydrochloride 37.5 mg/Paracetamol 325 mg tablets - tablet (Pfizer)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pfizer
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Acute Ischemic Stroke
Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke
Stroke is a major cause of death and long-term disability in the developed world. While t-PA and mechanical thrombectomy have been shown to decrease disability in properly selected patients, many patients are left with lifelong…
- Trial name
- NCT04918719
- Testing
- Acetylcysteine, Dextrose in Water
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Non-Hodgkin's Lymphoma
A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE)
This was a prospective, open-label, Phase III, multicenter, single-arm trial designed to assess the safety, pharmacokinetics, and pharmacodynamics of an alternative dosing rate of rituximab in previously untreated patients with…
- Trial name
- RATE (NCT00719472)
- Testing
- Rituximab, CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone), CVP (cyclophosphamide, vincristine, prednisone)
- Volunteers
- 451 people
- Sponsor
- Genentech, Inc.
Photorefractive Keratectomy, Myopia
Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control
Photorefractive Keratectomy (PRK) is a commonly performed corneal refractive surgery but has significant post-operative pain. Pain medications after PRK are typically opioid-acetaminophen combinations.
- Conditions
- Photorefractive Keratectomy, Myopia, Hyperopia
- Trial name
- NCT05477875
- Testing
- oral cannabinoid, oral codeine/acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Nephrolithiasis
Ureteral Stent-related Pain and Mirabegron (SPAM) Trial
Ureteric stents are used often following ureteroscopy for prevention of obstruction from edema and or stone fragments. They are often associated with pain, voiding often, the need to urinate quickly and finding blood in the urine…
- Trial name
- SPAM (NCT02095665)
- Testing
- Mirabegron, Tamsulosin, Tylenol #3
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis of the Knee
Structured Non-operative Treatment of Knee Osteoarthritis
The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with…
- Trial name
- NCT01535001
- Testing
- Neuromuscular training (NEMEX-TJR), Information, Paracetamol
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Fever
Study of the Efficacy and Safety of Intravenous vs Oral Acetaminophen for Treatment of Fever in Healthy Adult Males
To assess the rapidity of onset of antipyretic effect and the efficacy and safety of a single dose of IV acetaminophen (IV APAP) versus oral (PO) acetaminophen in the treatment of fever induced by a standard dose of endotoxin
- Trial name
- NCT00564629
- Testing
- Reference standard endotoxin (RSE)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
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