Clinical trials: Amlodipine
Hypertension, Concurrent Obesity
Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects
This study investigated the effects of LCZ696 on insulin sensitivity, lipolysis, and oxidative metabolism in obese hypertensive subjects.
- Trial name
- NCT01631864
- Testing
- LCZ696, amlodipine
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Safety and Pharmacokinetics of Besylsartan Tablet in Healthy Male Subject
This clinical trial was evaluated to compare the safety and pharmacokinetics of Besylsartan with Amosartan, which was available commercially after single oral dose in healthy male subjects.
- Trial name
- NCT02504606
- Testing
- Besylsartan, Amosartan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Hypertension, Obesity
Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients
Obesity is a complex metabolic state at which many pathophysiological pathways seem to interfere, like imbalance of autonomic nervous system, as well as renin-angiotensin-aldosterone system (RAAS) activation.
- Trial name
- HEBRO (NCT03476616)
- Testing
- Eplerenone (-based therapy) arm, Valsartan (-based therapy) arm
- Where
- Greece
- Volunteers
- 198 people
- Sponsor
- Hippocration General Hospital
Hypertension
CKD-828 (40/5mg) Pharmacokinetic Study
The purpose of this study is to evaluate the pharmacokinetic characteristics of CKD-828 (Fixed Dose Combination Tablet; Telmisartan and S-Amlodipine) in healthy volunteer.
- Trial name
- NCT01340131
- Testing
- CKD-828, Combination Therapy
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Essential Hypertension
Amlodipine as add-on to Olmesartan in Hypertension
Test the efficacy and safety of the combination of olmesartan and amlodipine in hypertensive patients whose blood pressure is not adequately controlled with olmesartan alone.
- Trial name
- NCT00220220
- Testing
- olmesartan medoxomil, amlodipine
- Where
- 6 sites in Germany
- Volunteers
- 429 people
- Sponsor
- Sankyo Pharma Gmbh
Essential Hypertension
Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension
This study is designed to compare the safety and efficacy of levamlodipine besylate (2.5mg or 5mg) versus amlodipine maleate (5mg) in patients with mild to moderate essential hypertension.
- Trial name
- NCT01131546
- Testing
- Levamlodipine besylate, Amlodipine maleate
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Healthy Volunteers
Drug-drug-interaction Study of Candesartan, Amlodipine and Atorvastatin
Study to determine the potential pharmacokinetic interaction of candesartan cilexetil, atorvastatin as atorvastatin calcium trihydrate and amlodipine as amlodipine besilate at steady state after a multiple oral administration and…
- Trial name
- NCT04245046
- Testing
- Candesartan, Amlodipine, Atorvastatin
- Where
- Jordan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Midas Pharma GmbH
Essential Hypertension
S-amlodipine in Essential HypertensIon and Assessment of Blood Pressure Targets Achievement
Evaluate the ratio(%) of patients whose blood pressure measured at 6 months from the baseline was confirmed to be within the target blood pressure range according to the 2022 hypertension treatment guidelines for essential…
- Trial name
- NCT06130124
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Hypertension
Treatment of Resistant Hypertension by Prevention of T-Cell Co-Stimulation
The purpose of this study is to test whether abatacept, a drug approved by the Food and Drug Administration to treat rheumatoid arthritis, may help blood pressure medications to work better.
- Trial name
- NCT02232880
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, Hyperlipidemia
Study to Evaluate the Safety and Efficacy of CJ-30061 in Hypertensive Patients With Hyperlipidemia
To evaluate the safety and efficacy of CJ-30061 compared with amlodipine/valsartan combination therapy and valsartan/atorvastatin combination therapy in hypertensive patients with hyperlipidemia
- Trial name
- NCT03639480
- Testing
- Amlodipine 10mg+Valsartan 160mg+Atorvastatin 40mg, Amlodipine 10mg+Valsartan 160mg, Valsartan 160mg+Atorvastatin 40mg
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- HK inno.N Corporation
Hypertension
The Efficacy of a Combination of Telmisartan/S-Amlodipine Compared With Telmisartan Monotherapy
The Efficacy of a Fixed Dose Combination of Telmisartan/S-Amlodipine on 24-hour Ambulatory BP Control Compared with Telmisartan Monotherapy
- Trial name
- TENUVA-BP (NCT02231788)
- Testing
- Telminuvo®Tab. 40/2.5mg, Telmitrend®Tab. 80mg
- Where
- 11 sites in South Korea
- Volunteers
- 217 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension, Renal
Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.
Hypertension is highly prevalent in hemodialysis (HD) patients and leads to increased morbidity and mortality due to cardiovascular disease(CVD).
- Trial name
- NCT04085562
- Testing
- Bisoprolol Fumarate 5-10 mg, Amlodipine 5-10 mg
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Alexandria University
Ovarian Cancer, Antiangiogenic-Associated Hypertension
Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension
Antiangiogenic therapies like bevacizumab, have notably improved cancer treatment, including for gynecological cancers, by inhibiting the vascular endothelial growth factor and thus limiting tumor growth.
- Conditions
- Ovarian Cancer, Antiangiogenic-Associated Hypertension, Adjuvant Bevacizumab, Hypertension
- Trial name
- IATRO (NCT06515678)
- Testing
- arm A - angiotensin converting enzyme inhibitors (ACEi), arm B - calcium channel blockers (CCBs), arm R - angiotensin receptor blockers ARB
- Where
- 2 sites in France
- Volunteers
- 9,464 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Hypertension, Vascular Stiffness
Arterial Stiffness and Blood Pressure
Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and…
- Conditions
- Hypertension, Vascular Stiffness, Aging
- Trial name
- LOADED-BP (NCT06495710)
- Testing
- Blood pressure treatment algorithm
- Where
- 3 sites in United States
- Volunteers
- 228 people
- Sponsor
- VA Office of Research and Development
Hypertension
Comparision of Blood Pressure Variability Between Amlodipine and Losartan
Blood pressure (BP) is believed to be a major determinant of vascular disease, and BP lowering is the most important goal in hypertension treatment.
- Trial name
- NCT01964079
- Testing
- Amlodipine, Losartan
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Wonju Severance Christian Hospital
Independent Living, Disability Free Survival
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)
The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong disability free survival and reduce major cardiovascular events amongst healthy elderly people (≥70 years).
- Conditions
- Independent Living, Disability Free Survival, Elderly, Healthy
- Trial name
- STAREE (NCT02099123)
- Testing
- Atorvastatin
- Where
- 6 sites in Australia
- Volunteers
- 9,971 people, healthy volunteers welcome
- Sponsor
- Monash University
Hypertension
Safety and Efficacy of Daily Use of Micamlo® Combination Tablets AP in Patients With Hypertension
Investigation of safety and efficacy of daily use of Micamlo Combination Tablets AP in patients with Hypertension
- Trial name
- NCT01353274
- Testing
- Micamlo
- Where
- 254 sites in Japan
- Volunteers
- 1,157 people
- Sponsor
- Boehringer Ingelheim
Hypertension,Essential
Management of Hypertension Utilizing Trained Community Health Worker in Rural Municipalities of Nepal
The investigators will evaluate whether a system involving Female Community Health Volunteers (FCHVs) and facility-based community health workers (FB-CHWs) of Health Post (Auxiliary Health Workers, Auxiliary Nurse Midwives and…
- Trial name
- MUTU (NCT04521582)
- Testing
- Amlodipine, Lifestyle counselling
- Where
- 2 sites in Nepal
- Volunteers
- 1,428 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy
Safety and Pharmacokinetic Comparison of Exforge® and G-0081 in Healthy Male Volunteers
This study investigates safety and pharmacokinetic comparison of G-0081, a combination tablet of amlodipine and valsartan (test formulation), and Exforge®, a combination tablet of amlodipine and valsartan (reference formulation)…
- Trial name
- NCT01823913
- Testing
- Test formulation, Reference formulation
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Severance Hospital
Hypertension, Chronic Stable Angina
Bioequivalency Study of Amlodipine Tablets Under Fasting Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Amlodipine Besylate tablets, 10 mg, to Norvasc® Tablets, 10 mg (Pfizer) under fasting conditions using a single-dose, randomized, 2-treatment, 2-period…
- Conditions
- Hypertension, Chronic Stable Angina, Vasospastic Angina
- Trial name
- NCT00602017
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories