Clinical trials: Amlodipine
Healthy
Telmisartan, Amlodipine and Combination in Healthy Subjects
To determine the pharmacokinetic profile of 80 mg telmisartan / 5 mg amlodipine (T80/A5) dose combination after single dose in healthy Chinese subjects.
- Trial name
- NCT01181011
- Testing
- amlodipine/telmisartan/combination
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension
Pharmacokinetic Drug Interaction Study Following Co-administration of Valsartan, Hydrochlorothiazide and Amlodipine in Patients With Hypertension
The purpose of this study is to determine potential pharmacokinetic drug-drug interaction when three drugs (valsartan, amlodipine, and hydrochlorothiazide) are co-administered.
- Trial name
- NCT00548067
- Testing
- Valsartan/hydrochlorothiazide (HCTZ), Valsartan/amlodipine, Amlodipine/hydrochlorothiazide(HCTZ)
- Where
- 5 sites in India
- Volunteers
- 111 people
- Sponsor
- Novartis
Hypertension
Efficacy and Safety of Perindopril 5 mg / Indapamide 1.25 mg / Amlodipine 5 mg Fixed Combination in Hypertension
The purpose of this study is to investigate the efficacy and safety of a fixed-dose combination of perindopril 5 mg /indapamide 1.25 mg / amlodipine 5 mg compared to the free combination of the same components (perindopril 4 mg /…
- Trial name
- NCT05820880
- Testing
- Fixed [Per/Ind/Aml], Free [Per/Ind + Aml]
- Where
- 42 sites in China
- Volunteers
- 532 people
- Sponsor
- Institut de Recherches Internationales Servier
Hypertension
Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension
The purpose of this study is compare treatment with valsartan with the possible addition of a diuretic, hydrochlorothiazide, on high blood pressure with the drug amlodipine with the possible addition of a diuretic…
- Trial name
- NCT00171054
- Testing
- Valsartan 320 mg, Amlodipine 10 mg, Hydrochlorothiazide
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- Novartis
Hypertension, Hyperlipidemias
Pharmacokinetics Study of CJ-30060 After Single Dose Administration in Health Male Volunteers
To compare the pharmacokinetics and safety after a single dose administration of CJ-30060 and Exforge® 5/160mg, Crestor 10mg in healthy male volunteers.
- Trial name
- NCT03009474
- Testing
- CJ-30060, Exforge tab 5/160mg, Crestor tab 10mg
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Hypertension
Feasibility Study of a Novel mHealth Application to Enable Community Health Workers to Manage
This is a single group study assessing the feasibility of hypertension management by community health workers (CHWs) equipped with a mobile clinical decision support (CDS) application and working with remote physician supervision.
- Trial name
- NCT05479097
- Testing
- Anti-Hypertensive
- Where
- Guatemala
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Ischemic Heart Disease
Effect of Amlodipine on Anti-platelet Drug Effect in Patients With Coronary Artery Disease
Clopidogrel can reduce risk of cardiovascular disease by inhibiting platelet aggregation. It is metabolized to an active drug by a liver enzyme.
- Trial name
- NCT01203696
- Testing
- Amlodipine
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Ruttonjee Hospital
Cardiovascular Events
A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People
This study was planned to provide new information regarding the role of aliskiren (with or without additional therapy with a diuretic or a Calcium channel blockers (CCB)) in elderly individuals (≥ 65 years) with systolic blood…
- Trial name
- APOLLO (NCT01259297)
- Testing
- Aliskiren, Amlodipine, Hydrochlorothiazide (HCTZ)
- Where
- 185 sites in United States, Argentina and 16 more
- Volunteers
- 2,336 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Fimasartan and Amlodipine in Healthy Male Subjects
The purpose of this study is to evaluate the pharmacokinetics and safety when administrated Fimasartan/Amlodipine and when co-administrated Fimasartan and Amlodipine.
- Trial name
- NCT02920047
- Testing
- Fimasartan/Amlodipine, Fimasartan + Amlodipine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Essential Hypertension
Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus Amlodipine
This study will assess the efficacy and safety of the single pill combination of Aliskiren and Amlodipine in patients with moderate hypertension not adequately responding to a single pill combination of Olmesartan and Amlodipine.
- Trial name
- AWESOME (NCT01113047)
- Testing
- Aliskiren/Amlodipine and Aliskiren/Amlodipine/HCTZ
- Where
- Germany
- Volunteers
- 347 people
- Sponsor
- Novartis
Primary Aldosteronism, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Calcium Channel Blockade in Primary Aldosteronism
This pilot study explore whether the calcium channel blocker amlodipine can lower aldosterone levels in people with primary aldosteronism.
- Trial name
- CCB-PA (NCT04179019)
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Essential Hypertension
Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients
Hypertensive patients with moderate hypertension have a risk to develop cardiovascular events of 15-20% over a period of 10 years.
- Trial name
- NCT00716950
- Testing
- valsartan/amlodpine, losartan/amlodpine
- Where
- Italy
- Volunteers
- 187 people
- Sponsor
- University of Pavia
Hypertension, Atherosclerosis
Effect of Fimasartan on Extended RAS and Vascular Functions in Patients With Type 2 Diabetes and Hypertension
In this study, we will assess the change of extended renin-angiotensin system including serum ACE-2 and angiotensin(1-7) levels and subclinical atherosclerosis after using fimasartan (an ARB), compared to amlodipine in…
- Conditions
- Hypertension, Atherosclerosis, Diabetes Mellitus, Type 2, Renin Hypertension
- Trial name
- FAoRAS (NCT05173025)
- Testing
- Fimasartan
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Bundang Hospital
Healthy Volunteers
Pharmacokinetics of Irbesartan/Amlodipine High FDC and Co-administration of Irbesartan and Amlodipine High in Healthy Volunteers
The purpose of this study is to compare pharmacokinetics and safety of Irbesartan and Amlodipine High Fixed Dose Combination and coadministration of mono compounds in healthy adult volunteers
- Trial name
- NCT05688098
- Testing
- Irbesartan/Amlodipine High FDC, Irbesartan, Amlodipine High
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Handok Inc.
Blood Pressure
Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial
The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended…
- Trial name
- NOAAH (NCT01030458)
- Testing
- amlodipine 5/10 mg per day plus valsartan 160 mg/day, hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day
- Where
- 7 sites in Cameroon, Côte d’Ivoire and 3 more
- Volunteers
- 183 people
- Sponsor
- KU Leuven
Essential Hypertension
Monitoring the Effectiveness and Safety of Antihypertensive Therapy With a Fixed-Dose Combination of Perindopril and Amlodipine in Patients With Uncontrolled Essential Hypertension
The aim of this observational study is to monitor the effectiveness of therapy, adherence and safety of a fixed combination of perindopril + amlodipine in patients with essential hypertension.
- Trial name
- NCT07876895
- Testing
- fixed combination of perindopril + amlodipine
- Where
- Bosnia and Herzegovina
- Volunteers
- 600 people
- Sponsor
- Bosnalijek D.D
Hypertension, Hyperlipidemia
Evaluate Efficacy and Safety of Ezetimibe/Rosuvastatin and Candesartan Cilexetil/Amlodipine Besylate Combination Tablets
To evaluate the efficacy and the safety of concomitant use of Ezetimibe/Rosuvastatin combination tablets and Candesartan cilexetil/Amlodipine besylate combination tablets compared to each combination tablet alone in patients with…
- Trial name
- REVERT-K (NCT03847506)
- Testing
- Ezetimibe/Rosuvastatin, Candesartan cilexetil/Amlodipine besylate, Candesartan cilexetil
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- HK inno.N Corporation
Hypertension
Phase I Study to Investigate the Effect on the Blood Pressure After Oral Administration of SK3530 and Amlodipine
To assess the pharmacodynamic effects of co-administrated SK3530 (PDE5 inhibitor) and Amlodipine, phase I study in Hypertensive patient was designed.
- Trial name
- NCT00626743
- Where
- 2 sites in South Korea
- Volunteers
- 13 people
- Sponsor
- SK Chemicals Co., Ltd.
Hypertension, Dyslipidemia
Evaluate the Efficacy and Safety of Combination Treatment With DW1501-R1+DW1501-R2 Versus DW1501-R1 or DW1501-R2+DW1501-R3 in Patients With Hypertension and Dyslipidemia
A Multicenter, Randomized, Double-blinded, Double-dummy, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Treatment with DW1501-R1+DW1501-R2 Versus DW1501-R1 or DW1501-R2+DW1501-R3 in Patients with…
- Trial name
- NCT03210532
- Testing
- Telmisartan + Amlodipine + Rosuvastatin, Telmisartan + Amlodipine, Telmisartan + Rosuvastatin
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Hypertension With Hyperlipidemia
Study to Evaluate the Safety and Efficacy of CJ-30060 in Hypertensive Patients With Hyperlipidemia
To evaluate the safety and efficacy of CJ-30060 compared with amlodipine/valsartan combination therapy and valsartan/rosuvastatin combination therapy in hypertensive patients with hyperlipidemia
- Trial name
- NCT03536598
- Testing
- Amlodipine 10 mg + Valsartan 160 mg + Rosuvastatin 20 mg, Amlodipine 10 mg + Valsartan 160 mg, Valsartan 160 mg + Rosuvastatin 20 mg
- Volunteers
- 203 people
- Sponsor
- HK inno.N Corporation