Clinical trials: Amlodipine
Hypertension, Stroke
Recurrent Stroke Prevention Clinical Outcome Study
1. Objectives and Hypothesis 1. Objectives: This study evaluates whether strict BP management is useful for the prevention of recurrent stroke.
- Conditions
- Hypertension, Stroke, Blood Pressure
- Trial name
- RESPECTS (NCT01198496)
- Testing
- Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
- Where
- Japan
- Volunteers
- 5,000 people
- Sponsor
- Biomedis International Ltd.
Hypertension
Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.
The American College of Cardiology/American Heart Association hypertension guidelines recommend treatment initiation with dual antihypertensive therapy in adults with stage 2 hypertension (corresponding to grade 1 and 2 in the…
- Trial name
- HELP (NCT06625346)
- Testing
- Fixed-Dose Combination of Amlodipine/Valsartan
- Where
- 2 sites in Pakistan
- Volunteers
- 420 people
- Sponsor
- The Searle Company Limited Pakistan
Obesity, Hypertension
A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
Obesity and hypertension are independent risks for congestive heart failure (CHF) and chronic kidney disease. In obesity induced hypertension, the most common cause of human essential hypertension, the potential importance of…
- Trial name
- NCT00825188
- Testing
- eplerenone, amlodipine, eplerenone, amlodipine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Mississippi Medical Center
Hypertension
A Clinical Trial to Evaluate the Safety and Pharmacokinetics of AJU-C52H in Healthy Volunteers
To evaluate the safety and pharmacokinetic characteristics of AJU-C52H in healthy adults
- Trial name
- NCT05077462
- Testing
- C52R1M Tab. and C52R2 Tab., AJU-C52H
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AJU Pharm Co., Ltd.
Essential Hypertension, Dyslipidemia
Combination of Fimasartan/Amlodipine/Rosuvastatin in Patients With Essential Hypertension and Dyslipidemia
The objective of this clinical study is to evaluate the efficacy and safety by comparing the fimasartan/amlodipine/rosuvastatin treatment group to the fimasartan/amlodipine treatment group and the fimasartan/rosuvastatin…
- Trial name
- FIRST (NCT03156842)
- Testing
- Fimasartan/Amlodipine, Rosuvastatin, Fimasartan/Amlodipine, Fimasartan, Rosuvastatin
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
Randomized Controlled Trial of Renal Denervation for Resistant Hypertension
Hypertension represents a significant global public health problem, contributing to vascular and renal morbidity, cardiovascular mortality, and economic burden.
- Trial name
- NCT02900729
- Testing
- Radiofrequency ablation catheter, Amlodipine, losartan potassium and hydrochlorothiazide
- Where
- 13 sites in China
- Volunteers
- 254 people
- Sponsor
- Shanghai WiseGain Medical Devices Co., Ltd.
Post-stroke Pneumonia
Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study
The goal of this retrospective cohort study is to determine if Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs) can lower the risk of post-stroke pneumonia.
- Trial name
- NCT07262710
- Testing
- angiotensin converting enzyme inhibitors, Calcium Channel Blockers, Angiotensin Receptor Blockers
- Volunteers
- 13,656 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Hypertension, Blood Pressure
Morning Versus Bedtime Dosing of Antihypertensive Medication
Previous studies have shown that elevated nighttime blood pressure (BP) was more closely associated with cardiovascular mortality and morbidity than daytime and clinic BPs.
- Conditions
- Hypertension, Blood Pressure, Drug Use
- Trial name
- NCT05089448
- Testing
- Alisartan, Amlodipine besylate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Yan Li
Ischemic Heart Disease
Effect of Amlodipine on Anti-platelet Drug Effect in Patients With Coronary Artery Disease
Clopidogrel can reduce risk of cardiovascular disease by inhibiting platelet aggregation. It is metabolized to an active drug by a liver enzyme.
- Trial name
- NCT01203696
- Testing
- Amlodipine
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Ruttonjee Hospital
Hypertension
Study to Confirm the Efficacy and Safety of Fixed-dose Combinations of Amlodipine and Candesartan
To evaluate the efficacy and safety of amlodipine besylate and candesartan cilexetil administered in a fixed-dose combination tablet versus co-administered as their separate formulations in patients with essential hypertension…
- Trial name
- MACH (NCT03231982)
- Testing
- Group I, Group II
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- HK inno.N Corporation
Metabolic Syndrome, Lipotoxicity
Regression of Fatty Heart by Valsartan Therapy
Traditionally, obesity is considered an indirect cause of heart disease. Obese individuals typically present with a number of traditional Framingham risk factors (hypertension, dyslipidemia, and type 2 diabetes), predisposing…
- Trial name
- NCT00745953
- Testing
- Valsartan, Hydrochlorothiazide
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Hyperlipidemias
DP-R212 Pharmacokinetic Study
An open-label, multiple-dose study to evaluate the pharmacokinetic drug-drug interaction of amlodipine and rosuvastatin in healthy adult male subjects.
- Trial name
- NCT02789475
- Testing
- Amlodipine, Rosuvastatin
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Alvogen Korea
Atherosclerosis, Cardiovascular Diseases
Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions
This study will compare medical therapy plus stenting of hemodynamically significant renal artery stenoses versus medical therapy alone in patients with systolic hypertension and renal artery stenosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Hypertension, Renovascular, Renal Artery Obstruction
- Trial name
- CORAL (NCT00081731)
- Testing
- Atacand/HCT, Caduet, GENESISTM Embolic Protection Stent and Angioguard Device (Angioplasty plus stenting)
- Where
- United States
- Volunteers
- 947 people
- Sponsor
- Baim Institute for Clinical Research
Hypertension, Dialysis
Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients
Hypertensive haemodialysis patients are at high risk for cardiovascular events. This study was undertaken to ascertain whether aliskiren, a direct renin inhibitor, compared with amlodipine, a calcium channel blocker, reduces…
- Trial name
- NCT01394770
- Testing
- Aliskiren
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hypertension in Pregnancy
Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension
A significant number of pregnancies are complicated by hypertensive disorders. Hypertension often worsens in the postpartum period and many women need started on medications.
- Trial name
- NCT04790279
- Testing
- Amlodipine, NIFEdipine ER
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Prisma Health-Upstate
Metastatic Triple Negative Breast Cancer
L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients
This is a Phase Ib/II study assessing the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), recommended Phase 2 dose (RP2D), and efficacy of L-NMMA when combined with docetaxel in refractory locally advanced or…
- Trial name
- NCT02834403
- Testing
- L-NMMA, Docetaxel, Amlodipine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- The Methodist Hospital Research Institute
Hypertension
Study of Efficacy and Safety of Irbesartan/Amlodipine 4 Fixed Combination Therapy in Hypertensive Patients Uncontrolled on Irbesartan or Amlodipine Monotherapy
Primary Objective: To assess the proportion of patients with controlled Office Blood Pressure Measurements (OBPM), defined as Systolic blood pressure < 140 mmHg and Diastolic blood pressure <90mmHg, at the end of the study…
- Trial name
- NCT01625494
- Testing
- Irbesartan/Amlodipine (150/5mg), Irbesartan/Amlodipine (150/10mg), Irbesartan/Amlodipine (300/5mg)
- Where
- Russia
- Volunteers
- 158 people
- Sponsor
- Sanofi
Albuminuria
Effects of Amlodipine/Benazepril on Albuminuria in Hypertensive Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus is usually associated with high blood pressure, which is a risk factor for kidney disease. Aggressive blood pressure reduction is an important strategy to protect the kidney and reduce urinary protein…
- Trial name
- NCT00136773
- Testing
- amlodipine/benazepril
- Volunteers
- 332 people
- Sponsor
- Novartis
Healthy Male Subjects
Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects (N=60)
To assess the pharmacokinetic characteristics of valsartan and S-amlodipine after single oral administration of Exforge tab. 10/160mg, a combination formulation of valsartan and amlodipine as reference drug and Lodivixx tab
- Trial name
- NCT01819779
- Testing
- Exforge tab. 10/160mg, Lodivixx tab. 5/160mg
- Where
- South Korea
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Hypertension and Atrial Fibrillation
ARB and CCB Longest Combination Treatment on Ambulatory and Home BP in Hypertension With Atrial Fibrillation -Multicenter Study on Time of Dosing (ACROBAT)
Evaluation of 24-hour antihypertensive effect of long-acting ARB-CCB tablet administrated to hypertensive patients with atrial fibrillation, and comparison of 24-hour antihypertensive effect of long-acting ARB-CCB tablet between…
- Trial name
- ACROBAT (NCT01748253)
- Testing
- Telmisartan-amlodipine tablet administration group (morning), Telmisartan-amlodipine tablet administration group (bedtime)
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Acrobat Trial Group