Clinical trials: Amlodipine
Healthy
Safety and Pharmacokinetics Study of Amlodipine 10mg and Candesartan 32mg
Clinical trial to evaluate the pharmacokinetic interactions and safety between single dose of amlodipine 10mg and candesartan 32mg and the combination dose amlodipine 10mg with candesartan 32mg in healthy male volunteers.
- Trial name
- NCT01926652
- Testing
- candesartan cilexetil 32mg, amlodipine 10mg
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Hypertension
Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension
Hypertensive patients are at increased risk of developing LV hypertrophy and myocardial fibrosis, which cause diastolic dysfunction.
- Trial name
- NCT02973035
- Testing
- Amlodipine, Valsartan
- Where
- 4 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Asan Medical Center
Hypertension, Stroke
Diurnal Variation in Hypertensive Stroke Patients
This study was conducted to evaluate and compare the effectiveness of Amodipin® (amlodipine camsylate) with that of Cozaar® (losartan potassium) in hypertensive patients with an acute ischemic stroke by measuring their 24-hour…
- Trial name
- NCT01830517
- Testing
- Amlodipine, Losartan
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension, Essential Hypertension
Resistant Arterial Hypertension Cohort Study
The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used…
- Conditions
- Hypertension, Essential Hypertension, Resistant Hypertension
- Trial name
- RAHyCo (NCT01083017)
- Testing
- chlorthalidone, motivational intervention for non-compliant individuals, standardized anti-hypertensive treatment
- Where
- 3 sites in Switzerland
- Volunteers
- 74 people
- Sponsor
- University Hospital, Geneva
Hypertension
MK-0954E Study in Participants With Hypertension (MK-0954E-357)
This study is being done to evaluate the efficacy, safety, and tolerability of losartan potassium 50 mg (L50) + hydrochlorothiazide 12.5 mg (H12.5) + amlodipine besylate 5 mg (A5) (MK-0954E).
- Trial name
- NCT01302691
- Testing
- losartan potassium + hydrochlorothiazide + amlodipine besylate (MK-0954E), Losartan potassium, Amlodipine besylate
- Volunteers
- 327 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension
Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives
The purpose of this study was to evaluate the effect of celecoxib on the efficacy and safety of amlodipine besylate on renal and vascular function in subjects with existing hypertension requiring antihypertensive therapy.
- Trial name
- NCT02979197
- Testing
- OE 10 mg amlodipine besylate tablet, OE 200 mg celecoxib capsule
- Where
- 9 sites in United Kingdom
- Volunteers
- 105 people
- Sponsor
- Kitov Pharma Ltd
Female Infertility Associated With Anovulation
Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.
- Trial name
- NCT02544776
- Testing
- Clomifene citrate ( clomid 50 mg ), Amlodipine
- Volunteers
- 60 people
- Sponsor
- Ahmed Fathy Ali Mohamed Ghanem
Hypertension
The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure
1. Study name: The comparison between spironolactone and indapamide monotherapy or in combination with amlodipine to reduce thr risk of heart failure (SIRRHF) 2.
- Trial name
- SIRRHF (NCT04455178)
- Testing
- Spironolactone, Indapamide
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Hypertension
A National Multicentre Study to Assess the Efficacy of the Fixed Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled by Monotherapy
This study is to assess the efficacy of the fixed combination of Valsartan and Amlodipine in hypertensive patients uncontrolled by monotherapy.
- Trial name
- NCT01241487
- Testing
- valsartan/amlodipine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Novartis
Hypertension
Filtered Trial for Amlodipine Non-responder
To demonstrate that a fixed-dose combination of telmisartan 40 mg plus amlodipine 5 mg is superior to amlodipine 5 mg alone in patients with essential hypertension and inadequately controlled with amlodipine 5 mg monotherapy.
- Trial name
- NCT00558064
- Testing
- telmisartan+amlodipine, amlodipine
- Where
- 41 sites in Japan
- Volunteers
- 531 people
- Sponsor
- Boehringer Ingelheim
Primary Hypertension
A Study to Compare the Efficacy, Safety and Tolerability of Selomax With Its Individual Components
This is a randomised, open-label; parallel group, multicentric study comparing the efficacy and safety of fixed-dose-combinations of Metoprolol XL plus Amlodipine with individual components of the combination.
- Trial name
- MARS (NCT00819104)
- Testing
- Metoprolol XL 50mg + Amlodipine 5mg, Metoprolol XL 25 mg + Amlodipine 2.5mg, Metoprolol XL 50mg
- Where
- 11 sites in India
- Volunteers
- 402 people
- Sponsor
- AstraZeneca
Hypertension
8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension
The purpose of this study is to determine the safety and efficacy of the various combinations of valsartan, HCTZ, and amlodipine in patients with moderate to severe hypertension.
- Trial name
- NCT00327587
- Testing
- Valsartan + amlodipine, Valsartan + HCTZ, Amlodipine + HCTZ
- Where
- United States
- Volunteers
- 2,279 people, healthy volunteers welcome
- Sponsor
- Novartis
Hypertension, Concurrent Obesity
Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects
This study investigated the effects of LCZ696 on insulin sensitivity, lipolysis, and oxidative metabolism in obese hypertensive subjects.
- Trial name
- NCT01631864
- Testing
- LCZ696, amlodipine
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Lower Leg Edema, Orthostatic Hypertension
Observational Study to Evaluate the Safety and Efficacy for Levacalm Tab. Versus Valsartan/Amlodipine Combination Therapy in Essential Hypertension Patients
Levacalm Tab. was approved in Jul 2013 by MFDS in South Korea. Levacalm Tab. is combination drug of Valsartan as an angiotensin II receptor blocker and Lercanidipine as a Calcium channel blocker.
- Trial name
- NCT02415192
- Testing
- Levacalm, Valsartan/amlodipine
- Where
- South Korea
- Volunteers
- 2,001 people
- Sponsor
- LG Life Sciences
Healthy Subjects
Bioequivalence of Levamlodipine Besylate Tablets in Healthy Chinese Subjects
The single-dose randomized, open-label, two-period crossover study was executed in the Phase I Clinical Research Center of the Affiliated Hospital of Qingdao University.
- Trial name
- NCT04411875
- Testing
- Amlodipine 10 mg, Levamlodipine 5 mg
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Healthy
Bioequivalence Study of Telmisartan/Amlodipine Fixed Dose Combination Compared With Its Monocomponents in Healthy Male and Female Volunteers
Study to demonstrate the bioequivalence of 40 mg telmisartan / 5 mg amlodipine fixed dose combination vs. its monocomponents
- Trial name
- NCT02259829
- Testing
- Telmisartan/Amlodipine, Telmisartan, Amlodipine
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension, Diabetes
Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM)
The primary objective of this study is to determine if trandolapril/verapamil (Tarka®) is superior to amlodipine/benazepril (Lotrel®) in reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and…
- Conditions
- Hypertension, Diabetes, Proteinuria
- Trial name
- TANDEM (NCT00234871)
- Testing
- trandolapril/verapamil, Lotrel (amlodipine/benazepril)
- Volunteers
- 357 people
- Sponsor
- Abbott
Thalassemia
Amlodipine for Myocardial Iron in Thalassemia
Children with thalassemia may have high iron levels after receiving blood transfusions. These high iron levels can have damaging effects on the body, especially the heart.
- Trial name
- AMIT (NCT02065492)
- Testing
- Standard Chelation, Amlodipine
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Aga Khan University
Primary Aldosteronism
Efficacy and Safety of Finerenone vs. Spironolactone in Patients With Primary Aldosteronism
To study the efficacy and safety of finerenone vs. spironolactone in patients with primary aldosteronism
- Trial name
- FAVOR (NCT06164379)
- Testing
- Finerenone, Spironolactone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Angina
Double Blind Atorvastatin Amlodipine Study
To evaluate and compare the safety and efficacy of amlodipine, atorvastatin and the combination in patients with symptomatic myocardial ischemia.
- Trial name
- DUAAL (NCT00159718)
- Testing
- amlodipine, atorvastatin
- Where
- 33 sites in Croatia, Czechia and 9 more
- Volunteers
- 360 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.