Clinical trials: Amlodipine
Hypertension, Dyslipidemias
The Efficacy and Safety of Triple Therapy of Telmisartan/Amlodipine/Rosuvastatin
The goal of this study was to assess the efficacy and safety of FDC therapy with triple therapy of Telmisartan 40 mg/Amlodipine 5 mg/Rosuvastatin 10mg in Korean patients with both hypertension and dyslipidemia.
- Trial name
- NCT03860220
- Testing
- NEWSTATIN TS, CADUET
- Where
- 9 sites in South Korea
- Volunteers
- 252 people
- Sponsor
- Hyo-Soo Kim
Hypertension
A Regulatory Requirement Post-Marketing Surveillance Study to Monitor the Safety and Efficacy of Twynsta (Telmisartan + Amlodipine SPC, q.d.) in Korean Hypertensive Patients Requiring Combination Therapy
This is a prospective, observational, open-label, multi-center study, which will provide detailed information about the safety and efficacy of Twynsta tablets in Korean hypertensive patients requiring combination therapy.
- Trial name
- NCT01243268
- Testing
- Twynsta tablet
- Where
- South Korea
- Volunteers
- 674 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Hyperlipidemias
Pharmacokinetics Study of CJ-30060 After Single Dose Administration in Health Male Volunteers
To compare the pharmacokinetics and safety after a single dose administration of CJ-30060 and Exforge® 5/160mg, Crestor 10mg in healthy male volunteers.
- Trial name
- NCT03009474
- Testing
- CJ-30060, Exforge tab 5/160mg, Crestor tab 10mg
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Bypass Bariatric Surgery
Analysis of the Influence of Gastric By-Pass on the Pharmacokinetics of Common Drugs
Lack of knowledge of digestive absorption of drugs used in metabolic syndrome (MS) before and after gastric by-pass (GBP) in obese patients.
- Trial name
- ABSORGYP (NCT06460896)
- Testing
- pharmacokinetic study
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension
The purpose of this study is compare treatment with valsartan with the possible addition of a diuretic, hydrochlorothiazide, on high blood pressure with the drug amlodipine with the possible addition of a diuretic…
- Trial name
- NCT00171054
- Testing
- Valsartan 320 mg, Amlodipine 10 mg, Hydrochlorothiazide
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- Novartis
Essential Hypertension
Clinical Efficacy and Safety Evaluation of Irbesartan and Amlodipine Combined Therapy in Essential Hypertension Patients
The purpose of this study is to evaluate efficacy and safety of Irbesartan and Amlodipine combined therapy in patients with essential hypertension inadequately controlled on Irbesartan monotherapy
- Trial name
- NCT05476354
- Testing
- Irbesartan/Amlodipine low, Irbesartan/Amlodipine high, Irbesartan
- Where
- South Korea
- Volunteers
- 271 people
- Sponsor
- Handok Inc.
Essential Hypertension
Essential Hypertension
The purpose of this study is to demonstrate the antihypertensive efficacy of once daily oral administration of ACT 280778 on DBP compared to placebo after 28 days.
- Trial name
- REDUCE-1 (NCT01264692)
- Testing
- ACT-280778, Amlodipine
- Where
- 18 sites in Israel, Serbia
- Volunteers
- 196 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Healthy Male Subjects
Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects
To assess the pharmacokinetic characteristics of Lodivixx tab.5/160mg in healthy male subjects PK parameter evaluation Safety profile evaluation
- Trial name
- NCT01652339
- Testing
- Exforge tab. 10/160mg, Lodivixx tab. 5/160mg
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Healthy
Telmisartan, Amlodipine and Combination in Healthy Subjects
To determine the pharmacokinetic profile of 80 mg telmisartan / 5 mg amlodipine (T80/A5) dose combination after single dose in healthy Chinese subjects.
- Trial name
- NCT01181011
- Testing
- amlodipine/telmisartan/combination
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Arterial and Arteriolar Disorders
Amlodipine Plus/Minus Atorvastatin for Protection of Arteries
The primary objective of this study is to test the hypothesis that amlodipine plus atorvastatin given in a single tablet (Caduet), compared with amlodipine alone (Norvasc), has a stronger effect in protection of arterial…
- Trial name
- NCT01922687
- Testing
- amlodipine plus atorvastatin (Caduet), amlodipine (Norvasc)
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Shanghai Institute of Hypertension
Hypertension, Hyperlipidemia
The Pharmacokinetic Drug Interaction Between Rosuvastatin and Telmisartan/Amlodipine
A randomized, open-label, multiple-dose, crossover study to investigate the pharmacokinetic drug interaction between rosuvastatin and telmisartan/amlodipine in healthy male volunteers
- Trial name
- NCT02387619
- Testing
- Rosuvastatin, Telmisartan/Amlodipine, Rosuvastatin and Telmisartan/Amlodipine
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Hypertension, Potassium Imbalance
Occurrence of Dyskalemia With Treatment for Hypertension
Hypertension is a major public health issue associated with significant morbidities and mortality. Fixed-dose combination (FDC) pills, combining 2 or more classes of antihypertensive medications have considerable appeal because…
- Trial name
- OK (NCT05155436)
- Testing
- Fixed Dose Combination pill of Telmisartan 40mg and Amlodipine 5 mg
- Where
- Bangladesh
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- National Heart Foundation of Bangladesh
Essential Hypertension
A Multicenter, Randomized, Double-Blind Phase 3 Trial of KDF1901 in Patients With Essential Hypertension
This randomized, double-blind, multicenter phase 3 clinical trial evaluated the efficacy and safety of KDF1901, a single-pill triple combination of valsartan, amlodipine, and chlorthalidone, in patients with essential…
- Trial name
- NCT07116863
- Testing
- KDF1901-R0, KDF1901-L, KDF1901
- Where
- 2 sites in South Korea
- Volunteers
- 286 people
- Sponsor
- Kyungdong Pharmaceutical Co., Ltd.
Metabolic Syndrome
Caduet and TLC Intervention in Metabolic Syndrome
To evaluate the effectiveness of Caduet in addition to therapeutic life-style change (TLC) intervention in resolving metabolic syndrome fifty three individuals were randomized to TLC intervention study with or without Caduet…
- Trial name
- NCT03504735
- Testing
- Therapeutic Lifestyle Change, Caduet Pill
- Volunteers
- 53 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypertension
Study of the Efficacy and Safety of LCZ696 Alone and in Combination With Amlodipine in Patients With Hypertension
To evaluate the blood pressure lowering effect and safety of LCZ696 when given alone and in combination with amlodipine in patients with essential hypertension.
- Trial name
- NCT01865188
- Testing
- LCZ696, Amlodipine, LCZ696 and amlodipine combination
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Transforming Hypertension Treatment in Nigeria Using a Type II Hybrid, Interrupted Time Series Design
The purpose of the Transforming Hypertension Treatment in Nigeria Program is to improve awareness, treatment, and control of hypertension in Nigeria through the adaptation, implementation, and evaluation of the effectiveness and…
- Trial name
- HTN (NCT04158154)
- Testing
- Evidence-based fixed-dose combination protocol based treatment
- Where
- 60 sites in Nigeria
- Volunteers
- 21,922 people
- Sponsor
- Washington University School of Medicine
Hypertension, Diabetes Mellitus
Comparison Between Losartan and Benazepril in Diabetic Hypertensive Patients Not Controlled by Amlodipine
The purpose of this study is to compare losartan and benazepril in diabetic patients whose high blood pressure is not controlled by amlodipine and its relationship to statin current use.
- Trial name
- CONTROL (NCT01603940)
- Testing
- Benazepril, Losartan
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Blood Pressure
Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial
The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended…
- Trial name
- NOAAH (NCT01030458)
- Testing
- amlodipine 5/10 mg per day plus valsartan 160 mg/day, hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day
- Where
- 7 sites in Cameroon, Côte d’Ivoire and 3 more
- Volunteers
- 183 people
- Sponsor
- KU Leuven
Hypertensive Nephrosclerosis, Chronic Renal Insufficiency
African American Study of Kidney Disease and Hypertension
The AASK is a multicenter, randomized, controlled clinical trial using a 2 × 3 factorial design to evaluate the effects of level of blood pressure control and type of anti-hypertensive medication on progression of chronic renal…
- Trial name
- AASK (NCT04364139)
- Testing
- MAP goal less than or equal to 92 mm Hg, MAP goal 102-107 mm Hg, Ramipril
- Volunteers
- 1,094 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypertension
Efficacy of a Combination of Amlodipine/Valsartan on 24H Blood Pressure Control With One Nocturnal or Diurnal Intake a Day
This study was a multicenter, randomized, PROBE-type (prospective, randomized, open label, blinded end-point) study of 12 weeks duration comprising four visits, carried out in patients with essential arterial hypertension not…
- Trial name
- NCT00700271
- Testing
- Amlodipine, Valsartan
- Where
- 2 sites in France, Tunisia
- Volunteers
- 478 people
- Sponsor
- Novartis Pharmaceuticals