Clinical trials: Amlodipine
Hypertension
A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study)
The primary objective of this study was test non-inferiority of telmisartan 80 mg + hydrochlorothiazide (HCTZ) 12.5 mg in comparison to amlodipine 10 mg + HCTZ 12.5 mg in reducing ambulatory systolic blood pressure (SBP) in the…
- Trial name
- NCT00240474
- Testing
- Telmisartan 80 mg + hydrochlorothiazide 12.5 mg, Amlodipine 10 mg + hydrochlorothiazide 12.5 mg
- Where
- 73 sites in Belgium, Denmark and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Hyperlipidemia
Amlodipine/Atorvastatin Combination to Reduce the Health Risk of High Blood Pressure and High Cholesterol Levels
The purpose of the study is to measure the effect of the amlodipine/atorvastatin combination pill in reducing both elevated blood pressure and cholesterol levels to levels suggested by guidelines
- Trial name
- GEMINI-AALA (NCT00143234)
- Testing
- Amlodipine/atorvastatin single pill
- Where
- 118 sites in Argentina, Australia and 25 more
- Volunteers
- 1,825 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add-on therapy.
- Trial name
- KARDIA-2 (NCT05103332)
- Testing
- Indapamide, Amlodipine, Olmesartan
- Where
- 110 sites in United States, Canada and 6 more
- Volunteers
- 663 people
- Sponsor
- Alnylam Pharmaceuticals
JNC 7 Stage 1 or 2 Hypertension
Efficacy and Safety of Nebivolol Versus Metoprolol in Hypertensive Subject Taking Amlodipine
Study is to evaluate the effect of Nebivolol to treat high blood pressure compared to an already approved drug, Metoprolol ER with background treatment of Amlodipine.
- Trial name
- NCT03635125
- Testing
- Nebivolol I, Nebivolol II, Baseline Washout Phase
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Trinity Hypertension & Metabolic Research Institute
Hypertension, Hyperlipidemia
Open Label Study To Assess The Effectiveness Of Amlodipine-Atorvastatin Combination In Hypertension And Dyslipidemia.
To evaluate the effectiveness of amlodipine/atorvastatin therapy by assessing the percentage of subjects who reach target blood pressure (BP) and LDL-C targets as defined by their governing guidelines.
- Trial name
- JEWEL II (NCT00174304)
- Testing
- Amlodipine/atorvastatin single pill
- Where
- 102 sites in Austria, Belgium and 9 more
- Volunteers
- 1,120 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Metabolic Syndrome
Gut Microbiomes in Patients With Metabolic Syndrome
Metabolic syndrome (MS) is defined by a manifestation of cardiometabolic risk factors including high blood pressure, glucose and triglycerides, low high-density lipoprotein (HDL) cholesterol, and abdominal obesity.
- Trial name
- NCT03489317
- Testing
- Metformin, lifestyle modification, Simvastatin 10mg
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hypertension
An Observation Study on the Identification of Prescription Patterns of Lodient Tab(Telmisartan/S-amlodipine)
This study identify prescription patterns of Lodient Tab and evaluate the changes of the hypertension symptoms (BP pressure) who are first prescribed and taking Lodient Tab.
- Trial name
- NCT06214832
- Where
- South Korea
- Volunteers
- 4,000 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Hypertension, Pharmacogenetics
A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
Blood pressure variation and the risk of essential hypertension have an important genetic component. In most cases susceptibility to essential hypertension is likely determined by the action of more than one gene.
- Trial name
- GENRES (NCT03276598)
- Testing
- Amlodipine, Bisoprolol, Hydrochlorothiazide
- Where
- Finland
- Volunteers
- 233 people
- Sponsor
- Helsinki University Central Hospital
Hypertension
Sevicontrol-1: Efficacy and Safety of a Fixed Combination of Olmesartan/ Amlodipine
The investigators want to find out whether a recently introduced combination of two blood pressure lowering agents (olmesartan and amlodipine) has a different blood pressure lowering effect than a single active substance.
- Trial name
- Sevicontrol1 (NCT01613209)
- Testing
- Candesartan cilexetil, Olmesartan/Amlodipin
- Where
- 12 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Metabolic Syndrome
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs glycemic control via effects on insulin sensitivity and insulin secretion. Aim 2.
- Trial name
- NCT02034435
- Testing
- Low Sodium diet plus Salt tablet, Epleronone, Amlodipine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Arterial Hypertension
The Use of TrIple Fixed-dose Combination in the Treatment of Arterial Hypertension
The use of TRIple fixed-dose COmbination in the treatment of arteriaL hypertension: opportunity for effective BP control with cOmbined antihypertensive therapy.
- Trial name
- TRICOLOR (NCT03722524)
- Testing
- amlodipine / indapamide / perindopril arginine FDC
- Where
- 51 sites in Russia
- Volunteers
- 1,247 people
- Sponsor
- Servier Russia
Hypertension
Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
To evaluate Drug-drug interaction
- Trial name
- NCT02152969
- Testing
- Telmisartan, Amlodipine, Chlorthalidone
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Hypertension
Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension
To determine the effectiveness of four different strength combinations of three approved anti-hypertension therapies (olmesartan medoxomil, amlodipine, and hydrochlorothiazide) for lowering blood pressure.
- Trial name
- NCT00649389
- Testing
- Olmesartan medoxomil, Amlodipine, Hydrochlorothiazide
- Where
- 232 sites in United States, Puerto Rico
- Volunteers
- 2,500 people
- Sponsor
- Daiichi Sankyo
Hypertension
Efficacy of Valsartan/Hydrochlorothiazide Versus Amlodipine and Hydrochlorothiazide in Patients Hypertension
This study will evaluate the efficacy of valsartan/hydrochlorothiazide versus amlodipine and hydrochlorothiazide in patients with Stage 2 hypertension using 24-hr ambulatory blood pressure monitoring (ABPM)
- Trial name
- NCT00425997
- Testing
- Valsartan/HCTZ, amlodipine, HCTZ
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Novartis
Healthy
A Bioequivalence Study of Valsartan / Amlodipine From Valsartan and Amlodipine Tablets (Hua Yuan Pharmaceutical LLC, China) and Valsartan and Amlodipine Tablets (Ⅰ) (Novartis Pharma Schweiz AG, Switzerland)
Comparative randomized, single dose, three periods, three-way crossover open-label study to determine the bioequivalence of Valsartan and Amlodipine Tablets (Hua yuan Pharmaceutical LLC, China) and Valsartan and Amlodipine…
- Trial name
- ABSVAFVATVAT (NCT04085627)
- Testing
- Valsartan and Amlodipine Tablets
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Arterial Hypertension
Fimasartan Plus Amlodipine on Hemodynamic Parameters and Arterial Stiffness in Patients With Hypertension
24-week open clinical trial to assess tolerability and effect on pressure, hemodynamic parameters and arterial rigidity of the combined treatment based on Fimasartan 60 mg and amlodipine besylate 5 mg given once daily in patients…
- Trial name
- NCT03294070
- Testing
- Fimasartan plus amlodipine besylate
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Hypertension
Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Stage 2 Hypertension
The purpose of this study is to evaluate the blood pressure lowering effects of an amlodipine/losartan combination treatment and amlodipine monotherapy for treatment of Stage 2 hypertensive patients.
- Trial name
- NCT01127217
- Testing
- amlodipine/losartan, amlodipine
- Where
- South Korea
- Volunteers
- 149 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Essential Hypertension
A Study to Evaluate the Pharmacokinetic Drug Interaction After Oral Concurrent Administration of Fimasartan and Amlodipine in Healthy Male Volunteers
To evaluate the pharmacokinetic drug interaction after oral concurrent administration of fimasartan and amlodipine in healthy male volunteers
- Trial name
- NCT00938197
- Testing
- Fimasartan, Amlodipine
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Dyslipidemia, Hypertension
A Multi-Risk Factor Strategy vs a Guideline-Based Approach in Achieving Blood Pressure and Lipid Goals in Hypertensives at Extra Risk
The purpose of this study is to investigate whether an aggressive multi-risk factor management strategy (Caduet plus therapeutic lifestyle changes (TLC) regimen) will result in greater percentage of patients achieving blood…
- Trial name
- TOGETHER (NCT00412113)
- Testing
- Amlodipine besylate, Amlodipine besylate/atorvastatin calcium single pill combination
- Where
- 51 sites in United States
- Volunteers
- 245 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
CKD-828 (80/5mg) Pharmacokinetic Study
A randomized, open-label, single-dose, four-period, two-way, crossover study,
- Trial name
- CKD-828 (NCT02358824)
- Testing
- CKD-828, Telmisartan, S-amlodipine
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical