Clinical trials: Amlodipine
Myotonic Dystrophy 1
Calcium Channel Blocker in Myotonic Dystrophy Type 1
This is a Phase 1 clinical trial designed to evaluate the safety and tolerability of amlodipine, a calcium channel blocker, in adults with Myotonic Dystrophy Type 1 (DM1).
- Trial name
- CAP DM1 (NCT07075965)
- Testing
- Amlodipine
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Hypertension
Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension
The study examined the efficacy of LCZ696 in comparison to the ARB olmesartan on Central Aortic Systolic Blood Pressure (CASP) and other measures of central hemodynamics and arterial stiffness in elderly patients with an elevated…
- Trial name
- NCT01692301
- Testing
- LCZ696, Olmesartan, amlodipine
- Where
- 47 sites in United States, Argentina and 10 more
- Volunteers
- 454 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, COVID-19
Coronavirus (COVID-19) ACEi/ARB Investigation
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- CORONACION (NCT04330300)
- Testing
- Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor
- Where
- Ireland
- Volunteers
- 2,414 people
- Sponsor
- National University of Ireland, Galway, Ireland
Hypertension, Chronic Kidney Disease
Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age
The purpose of this study is to assess the long-term safety and tolerability profile of valsartan and valsartan-based treatments in children with hypertension, with or without chronic kidney disease.
- Trial name
- NCT01365481
- Testing
- Valsartan, amlodipine, Hydrochlorothiazide
- Where
- 28 sites in Colombia, Finland and 8 more
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Self-Management
OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)
Hypertension (HTN) has a greater impact on African Americans (AA) than any other U.S. racial group. Uncontrolled blood pressure (BP) contributes to higher rates of disability, death, and health resource use among AA.
- Conditions
- Hypertension, Self-Management, Technology, Quality of Life
- Trial name
- NCT05293756
- Testing
- OPTIMA-BP Intervention
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Case Western Reserve University
Coronary Artery Bypass Graft Surgery (CABG), Radial Artery Grafts
Effect of Oral Isosorbide Mononitrate Plus Amlodipine Antispasm Therapy on Outcomes of Radial Artery Grafts After CABG
The goal of this clinical trial is to to evaluate the effect of oral isosorbide mononitrate plus amlodipine antispasm therapy on outcomes of radial artery grafts in patients underwent primary isolated CABG.
- Conditions
- Coronary Artery Bypass Graft Surgery (CABG), Radial Artery Grafts, Graft Failure
- Trial name
- ASRAB (NCT06730945)
- Testing
- Oral isosorbide mononitrate 4+ amlodipine
- Where
- China
- Sponsor
- Ruijin Hospital
We Searched for the Effects of Calcium Channel Blocker Amlodipine on the Clinical and Laboratory Parameters of Diabetic Patients With Proteinuria.
Effect of Calcium Channel Blocker on the Serum Fibrobalst Growth Factor-23 (FGF-23) Levels in Type-2 Diabetic Patients With Proteinuria Purpose
In recent years, diabetic nephropathy, which may lead to dialysis treatment, is the most prevalent underlying disease of people in developed countries.
- Trial name
- NCT01738945
- Testing
- Amlodipine
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gulhane School of Medicine
Hypertension
Default BP Medication Intensification
High blood pressure leads to heart attacks and strokes which can be prevented by blood pressure-lowering medication. However, the current office-based prescription of one pill and one dose at a time is ineffective.
- Trial name
- NCT01994408
- Testing
- default intensification
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Cedars-Sinai Medical Center
Healthy Subjects
BE Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tab - Fed Conditions
Subjects to compare the single dose bioavailability of Torrent's Olmesartan medoxomil, Amlodipine and Hydrochlorothiazide Tablets 40+10+25 mg and Tribenzor® 40+10+25 mg Tablets of Daichi Sankyo Inc, USA.
- Trial name
- NCT02962258
- Testing
- Torrent's Olmesartaan medoxomil, Amlodipine and Hydrochlorothiazide Tablets, Tribenzor of Daichi Sankyo Inc. USA
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Hypertension With Dyslipidemia
The PK Characteristics of the Co-administration of Rosuvastatin and Telmisartan/Amlodipine and JLP-1401 in Healthy Male Volunteers Volunteers
The PK Characteristics of the Co-administration of Rosuvastatin and Telmisartan/Amlodipine and JLP-1401 in Healthy Male Volunteers Volunteers
- Trial name
- NCT03247140
- Testing
- JLP-1401, Telmisartan/Amlodipine, Rosuvastatin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Healthy
Pharmacokinetics and Drug Interaction Study Between Amlodipine,Olmesartan and Rosuvastatin in Healthy Adult Volunteers
The purpose of this study is to evaluate the pharmacokinetics profile and drug-drug interaction between amlodipine, olmesartan and rosuvastatin in healthy adult volunteers.
- Trial name
- NCT02089399
- Testing
- Sevikar(amlodipne/olmesartan), crestor(Rosuvastatin)
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypertension
Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled Hypertension
This study will evaluate the efficacy and safety of valsartan and amlodipine in fixed dose combination in adults with moderate, inadequately controlled hypertension.
- Trial name
- NCT00523744
- Testing
- Amlodipine, Olmesartan medoxomil, Amlodipine+valsartan
- Where
- 2 sites in Germany
- Volunteers
- 257 people
- Sponsor
- Novartis
Essential Hypertension
Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients with Essential Hypertension
This study is to develop a predictive model for cardiocerebrovascular risk factors in elderly patients with essential hypertension with Telmisartan, Amlodipine, and Chlorthalidone Fixed-Dose Combination.
- Trial name
- NCT06282549
- Testing
- Telmisartan/Amlodipine/Chlorthalidone(Truset)
- Where
- 5 sites in South Korea
- Volunteers
- 1,219 people
- Sponsor
- Yuhan Corporation
Masked Hypertension
Mechanism of Masked Hypertension - Intervention
To test the hypothesis that sympatholytic antihypertensive antihypertensive therapy (αβ-blocker - carvedilol) will reduce out-of-clinic ambulatory BP to a greater extent by blocking sympathetic activity than non-sympatholytic…
- Trial name
- NCT04121299
- Testing
- Carvedilol, Amlodipine
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Essential Hypertension
Perindopril Amlodipine for the Treatment of Hypertension
The purpose of the study is to evaluate the safety and efficacy of a fixed-dose combination drug compared to two other drugs (monotherapies) in controlling hypertension.
- Trial name
- PATH (NCT01556997)
- Testing
- XOMA 985, Amlodipine Besylate, Perindopril Erbumine
- Where
- 48 sites in United States
- Volunteers
- 837 people
- Sponsor
- Symplmed Pharmaceuticals LLC
Essential Hypertension, Hypercholesterolemia
Effect of Atorvastatin on Carotid Intima Media Thickness
The investigators hypothesize that additive effects of combined antihypertensive medications and statin in a single pill combination may better reduce progression of vascular remodeling and inhibit atherosclerosis progression.
- Trial name
- NCT04306627
- Testing
- Perindopril/Amlodipine and Perindopril/Amlodipine/Atorvastatin treatment
- Volunteers
- 200 people
- Sponsor
- Yerevan State Medical University
Resistant Hypertension
Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension
Resistant hypertension (RH) accounted for a considerable proportion of patients with hypertension. It has been revealed to impose certain adverse effects on the prognosis of patients with cardiovascular diseases.
- Trial name
- NCT05545059
- Testing
- Sacubitril/valsartan, valsartan
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Obesity, Hypertension
Irbesartan Versus Amlodipine: The OBI Study
Objective: 1. To study the effectiveness of irbesartan 300mg and amlodipine 10 mg in 24h ambulatory blood pressure values in obese subjects 2. To study the drug specific effect in arterial stiffness 3.
- Trial name
- OBI (NCT00987662)
- Testing
- Irbesartan, Amlodipine
- Where
- Greece
- Sponsor
- Aristotle University Of Thessaloniki
Beta-Thalassemia, Iron Overload
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
This is a randomized, open label, two arms superiority trial of a representative population of patients with a primary diagnosis of transfusion dependent thalassemia with evidence of moderate cardiac iron overload, defined as an…
- Trial name
- CANALI (NCT02474420)
- Testing
- Amlodipine, Deferasirox
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Kevin H.M. Kuo, MD, MSc, FRCPC
Hypertension
Observational Cohort Study Evaluating the Effectiveness of an Educational Program (NGAYDAUTIEN) in Combination With Perindopril and Amlodipine Single-Pill Combination in Hypertensive Patients naïve of Antihypertensive Treatments.
The primary objective is to assess the change of systolic blood pressure from baseline after a 6-month follow up for hypertensive patients initiating Viacoram® plus an educational program (NGAYDAUTIEN) in comparison to…
- Trial name
- EDUHYPER (NCT06704815)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Servier Affaires Médicales