Clinical trials: Aspirin
Platelet Aggregation Inhibitors, Aspirin
GM03 - Platelet RNA Signatures of Aspirin
This study will involve healthy volunteers and patients with Type 2 diabetes. Eligible healthy volunteers will be invited to enroll into one of two protocols (A or B) and eligible patients with diabetes will be enrolled into…
- Conditions
- Platelet Aggregation Inhibitors, Aspirin, Ticagrelor, RNA
- Trial name
- NCT05278637
- Testing
- Aspirin, Ticagrelor
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Duke University
DRUG REACTIONS
Clinical Trial to Evaluate the Influence of Genotype and DDIs of Aspirin on the PK/PD of Clopidogrel and PK of Digoxin
Clinical trial to evaluate the influence of multiple aspirin administration on PK and PD of co-administered drugs
- Trial name
- NCT01775839
- Testing
- Aspirin+Clopidogrel/Digoxin(oral), Aspirin+Clopidogrel/Digoxin(IV)
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Coronary Stenosis, Coronary Thrombosis
Monitoring Response to Antiplatelet Therapy
Antiplatelet therapy plays a key role in the prevention of complications related to coronary angioplasty and stenting (PCI) including procedure related myocardial damage.
- Conditions
- Coronary Stenosis, Coronary Thrombosis, Angioplasty, Balloon
- Trial name
- NCT00327041
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Greater Glasgow and Clyde
Cerebral Infarction
Cilostazol in Acute Ischemic Stroke Treatment (CAIST)
The purpose of this study is to study efficacy and safety of cilostazol use in patients with acute ischemic stroke.
- Trial name
- NCT00272454
- Testing
- Cilostazol, Aspirin
- Where
- 12 sites in South Korea
- Volunteers
- 468 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Osteoarthritis of the Knee, Coagulopathy
Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants
The purpose of this study is to see if using a topical nonsteroidal antiinflammatory drug (Pennsaid) to treat osteoarthritis knee pain will affect coagulation values in patients who are also taking anticoagulant or antithrombotic…
- Trial name
- ATCCTCP-1 (NCT01511939)
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nathan Wei, MD, FACP, FACR:
Cardiovascular Disease
Single Pill to Avert Cardiovascular Events
The purpose of this study is to determine whether a polipill improved the compliance with treatment compared to usual care that use two or more drugs,in patients at high cardiovascular risk or previous cardiovascular disease.
- Trial name
- SPACE (NCT01313702)
- Testing
- polipillV1, polipillV2, usual care
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Intracranial Arteriosclerosis, Intracranial Artery Stenosis
Comparison Three vs Six Months of Dual Anti-platelet Therapy After Sirolimus-eluting Stent Implantation
This study is a prospective, multicenter, open-label, randomized controlled clinical trial, aims to assess the clinical non-inferiority of 3 months (short-term) vs 6 months (long-term) of Dual Anti-Platelet Therapy (DAPT) in…
- Conditions
- Intracranial Arteriosclerosis, Intracranial Artery Stenosis, Drug-Eluting Stents
- Trial name
- NCT06857045
- Testing
- NOVA intracranial sirolimus-eluting stent system
- Where
- China
- Sponsor
- Sino Medical Sciences Technology Inc.
Stroke, Ischemic
Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke
Intravenous thrombolysis is considered as the first choice for ischemic stroke. In the recent years, endovascular therapy is demonstrated to be effective to treat ischemic with big vessel occlusion.
- Trial name
- NCT03552354
- Testing
- Argatroban plus dual antiplatelet
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
Bleeding
Reversibility of Dual Antiplatelet Therapy by Platelets
The objective of the study is to test the hypothesis whether or not autologous stored platelets are able to offset the antiplatelet effect of aspirin and clopidogrel as assessed by state-of-the-art platelet function assays.
- Trial name
- NCT01248351
- Testing
- autologous stored platelets, administration of autologous stored platelets
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cerebral Microbleeds, Stroke
Cilostazol vs. Aspirin in Acute Non-cardioembolic Stroke With Cerebral mIcrobleeds
The purpose of this clinical trial is to demonstrate that cilostazol is non-inferior to aspirin in terms of efficacy and safety for the secondary prevention of stroke in patients with acute non-cardioembolic ischemic stroke who…
- Trial name
- NCT06530537
- Testing
- Cilostazol, Aspirin
- Where
- China
- Volunteers
- 848 people
- Sponsor
- Zhejiang Provincial People's Hospital
Chronic Low Back Pain
A Pilot Study Examining the Efficacy of Biomodulator Treatment for Chronic Low Back Pain
The purpose of this study is to determine the efficacy of self treatment with the Biomodulator device to decrease chronic low back pain (LBP) in active duty service members.
- Trial name
- NCT02707094
- Testing
- Biomodulator, Usual Care (Medication + Exercise)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brooke Army Medical Center
Polyps
Endoscopic Mucosal Colonic Resection and Polypectomy Under Aspirin
The endoscopic management of patients on anti platelet agents is a wide problem more and more common, with prevalence of patients on this type of therapy steadily increasing.
- Trial name
- OPERA (NCT01481337)
- Testing
- Colonic polypectomy or endoscopic mucosal resection (EMR)
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Société Française d'Endoscopie Digestive
Chest Pain, Acute Myocardial Infarction
Risk Score Alerts for Chest Pain Care
The evaluation of chest pain in the primary care office is a challenging problem, with many patients suffering from missed diagnoses of acute myocardial infarction and many other low risk patients receiving unnecessary…
- Trial name
- NCT00674375
- Testing
- Electronic risk alerts
- Where
- 2 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Harvard Vanguard Medical Associates
Renal Artery Stenosis
Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study)
Renal atherosclerotic stenosis (RAS) is a prevalent cause of secondary hypertension (HT). Since there are still uncertainties as to whether and in what patients revascularization by means of percutaneous renal angioplasty (PTRAS)…
- Trial name
- METRAS (NCT01208714)
- Testing
- Optimal medical therapy, revascularization
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital Padova
Disease Free Survival, Overall Survival
Efficacy of Chemopreventive Agents on Disease-free and Overall Survival in Patients With Pancreatic Ductal Adenocarcinoma: The CAOS Study
The evidence on the value of aspirin, statins, metformin, beta-blocking ACE inhibitors agents as chemopreventive agents in patients with pancreatic ductal adenocarcinoma is limited.
- Conditions
- Disease Free Survival, Overall Survival, Pancreatic Cancer
- Trial name
- CAOS (NCT04245644)
- Testing
- use of targeted drugs such as aspirin, B-Blockers, Metformin, ACE-inhibitors, Statins
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Massimo Falconi
Colorectal Cancer
Adjuvant Low Dose Aspirin in Colorectal Cancer
ALASCCA is a randomized, parallel group, double blind, multicenter, placebo-controlled, biomarker-based study of adjuvant treatment with low dose aspirin in patients with colorectal cancer.
- Trial name
- ALASCCA (NCT02647099)
- Testing
- Acetylsalicylic acid
- Where
- 32 sites in Denmark, Finland and 2 more
- Volunteers
- 626 people
- Sponsor
- Anna Martling
Coronary Artery
Combination Effects of High-dose Statin and Trimetazidine on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Coronary Artery Bypass Surgery
Trimetazidine is a metabolic agent without any negative inotropic or vasodilatory properties. In addition, previous reports showed that trimetazidine was effective in reducing intracoronary platelet aggregation and preventing…
- Trial name
- NCT01857921
- Testing
- Pravastatin 20mg/day for 12 months after randomization, Atorvastatin 40 mg and trimetazidine MR 70 mg/day for 12 months after randomization
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Yonsei University
Pneumonia
Randomised Evaluation of COVID-19 Therapy
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia. The treatments being investigated are: COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin…
- Trial name
- RECOVERY (NCT04381936)
- Testing
- Lopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
- Where
- 16 sites in Belgium, Estonia and 14 more
- Volunteers
- 70,000 people
- Sponsor
- University of Oxford
Myeloma
Bendamustine in Combination With Lenalidomide and Dexamethasone in Refractory or Relapsed Multiple Myeloma
The purpose of this study is to see if the combination of bendamustine, lenalidomide and dexamethasone will help people with multiple myeloma that has returned after standard treatment or has been resistant to other treatments.
- Trial name
- NCT01042704
- Testing
- Bendamustine, Lenalidomide, Dexamethasone
- Where
- 22 sites in United States
- Volunteers
- 29 people
- Sponsor
- Robert Redner, MD
Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery
This phase II trial studies how well enteric-coated (EC) aspirin and rintatolimod with or without interferon-alpha 2b work in treating patients with prostate cancer before surgery.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8
- Trial name
- NCT03899987
- Testing
- EC Aspirin, Radical Prostatectomy, Recombinant Interferon Alfa-2b
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Roswell Park Cancer Institute