Clinical trials: Atorvastatin
Atherosclerosis
Effect of Atorvastatin and Lifestyle Intervention on Progression of Pre-Clinical Atherosclerosis
The purpose of this study is to determine whether atorvastatin, aggressive lifestyle intervention, and their interaction are effective in delaying the progress of pre-clinical atherosclerosis.
- Trial name
- EALIPPCA (NCT00723320)
- Testing
- Atorvastatin, Aggressive lifestyle intervention
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Mixed Hyperlipidemia
Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To look at ultrasound images taken in the carotid arteries and to look at various lipids in the blood of people with mixed hyperlipidemia
- Trial name
- RADIANCE 2 (NCT00134238)
- Testing
- torcetrapib/atorvastatin, atorvastatin
- Where
- 51 sites in United States, Canada and 4 more
- Volunteers
- 755 people
- Sponsor
- Pfizer
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Psoriasis
Influence of Atorvastatin on Psoriasis Severity and Endothelial Function
Patients with psoriasis seem to have increased risk for developing atherosclerosis. This may be due to the fact that psoriasis and atherosclerosis are both caused by inflammation and involvement of cells of the immune system.
- Trial name
- NCT01527097
- Testing
- Atorvastatin
- Where
- Israel
- Sponsor
- shmuel fuchs
Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus
Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men
The aim of the study was to assess the effect of high intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetes males.It is a prospective study, conducted between march 2021 and July…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus, Statin Adverse Reaction, Hypogonadism, Male
- Trial name
- NCT05806723
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Hopital La Rabta
Hypertension, Hyperlipidemia
Study to Evaluate the Safety and Efficacy of CJ-30061 in Hypertensive Patients With Hyperlipidemia
To evaluate the safety and efficacy of CJ-30061 compared with amlodipine/valsartan combination therapy and valsartan/atorvastatin combination therapy in hypertensive patients with hyperlipidemia
- Trial name
- NCT03639480
- Testing
- Amlodipine 10mg+Valsartan 160mg+Atorvastatin 40mg, Amlodipine 10mg+Valsartan 160mg, Valsartan 160mg+Atorvastatin 40mg
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- HK inno.N Corporation
Coronary Artery Bypass Grafting
Efficacy of Different Perioperative Statin Regimens on the Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events
This study aims at comparing different perioperative statin regimens for the prevention of post CABG adverse events. This was a randomized, prospective clinical trial.
- Trial name
- NCT02706860
- Testing
- Atorvastatin
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypercholesterolemia
Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia
Primary Objective: To demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by alirocumab as add-on therapy to stable maximally tolerated daily statin therapy in comparison to ezetimibe 10 mg daily after 24…
- Trial name
- ODYSSEY EAST (NCT02715726)
- Testing
- Alirocumab, ezetimibe, atorvastatin
- Where
- 62 sites in China, India and 1 more
- Volunteers
- 615 people
- Sponsor
- Sanofi
Adverse Effects, Cardiovascular Diseases
Self-Assessment Method for Statin Side-effects Or Nocebo
Front-line clinicians cannot currently test for an individual participant whether symptoms experienced are the pharmacological result of a statin or due to other phenomena.
- Conditions
- Adverse Effects, Cardiovascular Diseases, Hyperlipidemias
- Trial name
- SAMSON (NCT02668016)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Overall Survival, Tumor Responses
Statin Combination Therapy in Patients Receiving Sorafenib for Advanced Hepatocellular Carcinoma
Target therapy with sorafenib is the standard of treatment for advanced Hepatocellular carcinoma (HCC), but the patient survival time is still unsatisfactory.
- Trial name
- NCT03275376
- Testing
- Atorvastatin 10mg
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Taichung Veterans General Hospital
Diabetes Melliuts, Type 2
Multiple Dose Study Of PF-05231023 In Adult Subjects Who Have Poor Lipid Control With And Without Type 2 Diabetes Mellitus
This is a trial in obese subjects who have poor lipid control with and without Type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics of multiple doses of PF-05231023
- Trial name
- NCT01673178
- Testing
- 25 mg PF-05231023, 50 mg PF-05231023, 100 mg PF-05231023
- Where
- 17 sites in United States
- Volunteers
- 107 people
- Sponsor
- Pfizer
Systemic Lupus Erythematosus
An Open Labeled Pilot Study of Atorvastatin in Systemic Lupus Erythematosus
The aim of this study is to to determine whether atorvastatin 40mg per day is effective in the treatment of SLE.
- Trial name
- NCT00432354
- Testing
- atorvastatin
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Heart Valve Diseases
Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair
The purpose of the investigation is to determine whether Atrovastatin as anti-inflammatory agent can be effective in preventing from atrial fibrillation incidence in patients whom undergone open cardiac surgery for their heart…
- Trial name
- NCT02084069
- Testing
- Atorvastatin
- Where
- Iran
- Volunteers
- 58 people
- Sponsor
- Urmia University of Medical Sciences
Healthy
Investigation of Interactions Between Faldaprevir, Itraconazole, Atorvastatin and Rosuvastatin
To investigate the effect of steady-state itraconazole on the pharmacokinetics of steady-state of faldaprevir and the effect of steady-state of faldaprevir on the single-dose pharmacokinetics of atorvastatin as well as the effect…
- Trial name
- NCT01795937
- Testing
- Itraconazole, Atorvastatin, Faldaprevir
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypercholesteremia
Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy
The primary objective of the study is to compare the efficacy of rosuvastatin 10 mg with atorvastatin 10 mg by assessment of the percentage of subjects who reach EAS LDL-C target goals after 12 weeks of therapy.
- Trial name
- NCT00239330
- Testing
- Rosuvastatin, Atorvastatin
- Where
- 26 sites in Belgium
- Volunteers
- 824 people
- Sponsor
- AstraZeneca
Hypercholesterolemia
Lipid-lowering Therapy Individualization
This clinical study will explore individual factors influencing statin pharmacokinetics in a cohort of 150 patients treated with atorvastatin.
- Trial name
- NCT03604471
- Testing
- Atorvastatin
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Université Catholique de Louvain
Hepatitis B, Chronic, Lipid Disorder
An Experimental Study on the Effect of Tenofovir Amibufenamide on Blood Lipid During Anti-HBV Treatment
In June 2021, Chinese Food and Drug Administration approved the launch of the self-developed new drug Tenofovir Amibufenamide(TMF). TMF is a new second generation of tenofovir(TFV) and its effect on blood lipids is unclear.
- Trial name
- NCT05398393
- Testing
- oral Tenofovir Amibufenamide 25mg each day, lipid lowering drugs (e.g. Atorvastatin and amlodipine.)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Coronary Syndrome, Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
Effect of Evolocumab Added to Moderate-Intensity Statin Therapy on LDL-C Lowering and Cardiovascular Adverse Events in Patients With Acute Coronary Syndrome
The study is an open-label, multicenter, and randomized study(five hospitals).The purpose of this study is to assess the differences in the effects of the evolocumab added to moderate-intensity statin therapy and the…
- Trial name
- EMSIACS (NCT04100434)
- Testing
- Evolocumab
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tianjin Chest Hospital
Healthy
Pharmacokinetic Interactions Between Amlodipine Besylate/Valsartan and Atorvastatin in Healthy Male Subjects
The purpose of the study is to assess the pharmacokinetic interactions between amlodipine besylate/valsartan and atorvastatin single or co-administered in healthy volunteers.
- Trial name
- NCT02069821
- Testing
- combination administration
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Chronic Periodontitis Wth Diabetes Mellitus
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
Statins are specific competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known for its hypolipidemic actions, possessing biologically significant anti-inflammatory and antioxidant properties…
- Trial name
- NCT03745300
- Testing
- ATORVASTATIN, SIMVASTATIN
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore