Clinical trials: Botulinum toxin type A, completed
Myofacial Pain Syndrome
The Use of Botulinum Toxin in the Management of Myofascial Pain Syndrome
The objective of this study was to assess the efficacy of Botulinum toxin type (A) (BoNTA) injection in Myofascial pain syndrome management in the terms of duration of function improvement and pain reduction.
- Trial name
- NCT06824324
- Testing
- intramuscular Botulinum Toxin
- Where
- Iraq
- Volunteers
- 14 people
- Sponsor
- Yassir R. Al-khannaq
Oral Dystonia, Tardive Dystonia
Dysport for the Treatment of OMD
The purpose of this study is to study the efficacy and safety of AbobotulinumtoxinA (Dysport) for use in Oromandibular Dystonia (OMD).
- Trial name
- NCT01921270
- Testing
- Low Dose - AbobotulinumtoxinA
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Stroke, Spasticity, Muscle
Efficacy of Extracorporeal Shock Wave Therapy on Spasticity
Introduction: We aimed to compare the efficacy of Botulinum Toxin Type A(BoNT-A) injection and BoNT-A injection in combination with ESWT for post-stroke lower extremity ankle plantar flexor spasticity.
- Trial name
- NCT06225024
- Testing
- ESWT, BoNT A
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kayseri City Hospital
Healthy
To Study the Peripheral Effect of Botulinum Toxin-A (Botox-A) on Experimentally Induced Cutaneous Pain in Healthy Subjects
This is a human trial to study the peripheral effect of therapeutic botulinum toxin (botox-A). The trial is performed on healthy normal males. The study comprises of two parallel placebo-controlled, double blinded studies.
- Trial name
- NCT00435682
- Testing
- Botox (Allergan Inc., US)
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aalborg University
Bruxism, Myofascial Pain
Ultrasonographic Evaluation of Masseter Muscle Changes After Botulinum Toxin Injection in Bruxism Patients
This prospective pilot study aimed to evaluate short-term clinical and ultrasonographic changes in the masseter muscle following botulinum toxin injection in patients with bruxism.
- Conditions
- Bruxism, Myofascial Pain, Masseter Muscle Hypertrophy
- Trial name
- NCT07545200
- Testing
- Botulinum Toxin A (Botox )
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Migraine Disorders
Sustained onabotulinumtoxinA Therapeutic Benefits in Patients With Chronic Migraine
To assess whether there is a sustained benefit and good safety with repeated onabotulinumtoxinA sessions in chronic migraine over more than three years of treatment.
- Trial name
- NCT03606356
- Testing
- Onabotulinum toxin A
- Volunteers
- 56 people
- Sponsor
- Corfu Headache Clinic
Blepharospasm
Study of a Single Administration of 3 Doses of Dysport® for the Treatment of Benign Essential Blepharospasm
The purpose of this study is to compare the effectiveness of 3 doses of Dysport® with placebo by assessing functional disability in blepharospasm.
- Trial name
- NCT00234507
- Testing
- Botulinum toxin type A
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- Ipsen
Overactive Bladder, Urinary Incontinence
A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence
A study to evaluate the efficacy and safety of BOTOX® or Solifenacin in patients with overactive bladder (OAB) and urinary incontinence.
- Trial name
- NCT01767519
- Testing
- BOTOX®, solifenacin
- Where
- 8 sites in United States, Belgium and 5 more
- Volunteers
- 356 people
- Sponsor
- Allergan
Hyperhidrosis
The Use of Microneedles With Topical Botulinum Toxin for Treatment of Palmar Hyperhidrosis
Hyperhidrosis or sweating of palms results from the overactivity of sweat glands and leads to psychosocial impairment with reduction in quality of life in those that are affected.
- Trial name
- NCT03203174
- Testing
- Microneedle, Botulinum Toxin Type A, Saline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Upper Limb Spasticity
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
This study is aiming to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to…
- Trial name
- DIRECTION (NCT04936542)
- Testing
- AboBoNT-A, OnaBoNT-A
- Where
- 76 sites in United States, Canada and 2 more
- Volunteers
- 464 people
- Sponsor
- Ipsen
Lateral Canthal Lines, Crow's Feet
Clinical Trial To Evaluate ANT-1207 In Subjects With Crow's Feet
The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of ANT-1207 in the treatment of Crow's Feet.
- Trial name
- NCT01358695
- Testing
- ANT-1207, Botulinum Toxin, Type A, Botulinum Toxin Type A
- Where
- 6 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Anterios Inc.
Sialorrhea
Efficacy and Safety Study of MYOBLOC® in the Treatment of Sialorrhea in Adult Subjects
This study will evaluate the efficacy and safety of MYOBLOC in the treatment of Sialorrhea (drooling), which can be a symptom of many disease conditions. MYOBLOC will be injected directly into the salivary glands.
- Trial name
- MYSTICOL (NCT01994109)
- Testing
- MYOBLOC
- Where
- 34 sites in United States, Russia and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Cerebral Palsy, Muscle Spasticity
Botulinum Toxin (BOTOX) for Cerebral Palsy
This study examines botulinum toxin (BOTOX, or BTX) for the treatment of muscle twitches and spasticity associated with cerebral palsy in children.
- Trial name
- NCT00060957
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity
Feasibility Pilot for the ReBOO-trial
This is a pilot testing the feasibility of the 'REpurposing BOtulinum Toxin in Treatment of Obesity in Adolescents' trial (ReBOO-trial).
- Trial name
- ReBOO (NCT03079557)
- Testing
- Intragastric botulinum toxin type A
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- St. Olavs Hospital
Masseter Muscle Hypertrophy
Xeomin Cosmetic in the Management of Masseter
The goal of this study was to evaluate the efficacy and safety of two injection techniques in the management of masseteric hypertrophy using Xeomin Cosmetic.
- Trial name
- NCT03376464
- Testing
- Xeomin Cosmetic
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Male Pattern Baldness
Treatment of Male Pattern Baldness With Botulinum Toxin
This proof of concept study seeks to demonstrate that Botulinum toxin injections are a safe and effective method for treating this form of hair loss.
- Trial name
- NCT00965640
- Testing
- Botulinum Toxin - A injections
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Crown Institute
Lateral Canthal Lines, Crow's Feet
Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults
The purpose of this study is to find out if an investigational drug, called RT001 Botulinum Toxin Type A Topical Gel, is safe and useful in minimizing the wrinkles between the eye and hairline called crow's feet, also known as…
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT01064518
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Frown Lines
Study to Compare 2 Botulinum Type A Toxins in the Treatment of Glabellar Frown Lines
The purpose of the study is to provide preliminary comparative data on BoNT/A-DP versus Botox Cosmetic. Subsequently the sample size is primarily based on clinical judgement and practical considerations.
- Trial name
- H2H (NCT04763265)
- Testing
- Botulinum toxin A "BoNT/A-DP", Botulinum toxin A "Botox Cosmetics"
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 208 people
- Sponsor
- Croma-Pharma GmbH
Axillary Hyperhidrosis
Botox and Suction-Curettage for Treatment of Excessive Underarm Sweating (Axillary Hyperhidrosis)
The purpose of this study is to compare the effectiveness of two methods in the treatment of excessive underarm sweating (axillary hyperhidrosis): suction-curettage and Botox injections.
- Trial name
- NCT01274611
- Testing
- Botulinum Toxin Type A, Suction-Curettage
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Benign Prostatic Hyperplasia
Safety and Efficacy Study of Botulinum Toxin Type A to Treat Lower Urinary Symptoms Due to Benign Prostatic Hyperplasia
The purpose of this study was to determine the safety and effectiveness of different doses of botulinum toxin Type A in treating lower urinary tract symptoms due to benign prostatic hyperplasia.
- Trial name
- NCT00284518
- Testing
- botulinum toxin Type A, normal saline
- Where
- 11 sites in Australia, Austria and 9 more
- Volunteers
- 380 people
- Sponsor
- Allergan