Clinical trials: Botulinum toxin type A
Chronic Anal Fissure
High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure
comparison between the effect of lateral sphincterotomy against high dose botox injection in chronic anal fissure the outcome was healing time, recurrence continence relapse pain pruritus
- Trial name
- professor (NCT04166175)
- Testing
- botox injection in intersphincteric space, lateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Zagazig University
Knee Pain
Safety and Efficacy of Botulinum Toxin A Injection in Patients With Painful Artificial Knee Arthroplasty (TKA)
Primary Total Knee joint replacement surgery is highly successful surgery for relieving pain and improving function in patients with disabling arthritis.
- Trial name
- NCT00403273
- Testing
- Botulinum toxin A, Normal Saline
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Painful Unilateral Femorotibial Knee Osteoarthritis of Any Etiology
Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection for the Treatment of Painful Knee Osteoarthritis
In France, osteoarthritis affects about 10 million people and knee osteoarthritis represents 35% of cases. It is thought that more than 2.5 million people older than 65 years have knee osteoarthritis.
- Trial name
- GOTOX (NCT02832713)
- Testing
- Botulinum toxin A ( BoNT-A), Hyaluronic acid (HA)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Hidradenitis Suppurativa, Hyperhidrosis
Targeting Nociceptors in Hidradenitis Suppurativa
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS).
- Trial name
- HS (NCT05403710)
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Worcester
Cerebral Palsy
The Effect of Botox on Children With Cerebral Palsy
Botulinum toxin injections are a common form of treatment for children with cerebral palsy to help reduce muscle tightness and help them walk without resorting to surgery.
- Trial name
- NCT00503620
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Moderate to Severe Upper Facial Lines
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines
The purpose of this study is to assess the safety and efficacy profile of increasing doses of Corabotase (also known as IPN10200) in comparison to placebo, with the aim to discover the doses(s) that offer the best efficacy/safety…
- Trial name
- LANTIC (NCT04821089)
- Testing
- Corabotase, Dysport
- Where
- 10 sites in France, Germany
- Volunteers
- 727 people
- Sponsor
- Ipsen
Hernia, Abdominal
This Randomized Controlled Study Aims to Investigate the Effect of Botox Injection in Abdominal Wall Muscle Post Major Abdominal Surgery in Terms of Postoperative Pain, Incidence of Incisional Hernia.
Aim of the work This randomized controlled study aims to investigate the effect of botox injection in abdominal wall muscle post major abdominal surgery in terms of postoperative pain, incidence of incisional hernia Study design…
- Trial name
- NCT04422197
- Testing
- Botox, surgery without botox injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Hyperhidrosis
The Use of Microneedles With Topical Botulinum Toxin for Treatment of Palmar Hyperhidrosis
Hyperhidrosis or sweating of palms results from the overactivity of sweat glands and leads to psychosocial impairment with reduction in quality of life in those that are affected.
- Trial name
- NCT03203174
- Testing
- Microneedle, Botulinum Toxin Type A, Saline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Dystonic Tremor Syndrome
Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia
Tremor occurs in up to 55% of dystonia patients, which is known as dystonic tremor syndrome (DTS). Tremor can be present in the body part affected by dystonia (dystonic tremor, DT), or an unaffected body part (tremor associated…
- Trial name
- BAT (NCT06411028)
- Testing
- Polymyography, Muscle ultrasound, (Functional) magnetic resonance imaging
- Where
- 3 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Platysma Prominence
BOTOX® for the Treatment of Platysma Prominence
To assess the efficacy and safety of BOTOX® in adults with moderate to severe platysma prominence.
- Trial name
- NCT03915067
- Testing
- BOTOX® purified neurotoxin complex
- Where
- 12 sites in United States, Canada
- Volunteers
- 171 people
- Sponsor
- Allergan
Healthy
Evaluate the Migration Potential of Xeomin® Compared to Two Other Botulinum Toxin Type A Products
Xeomin® is a Botulinum neurotoxin type A preparation free of complexing proteins, i.e. free of bacterial proteins other than the active toxin. Injected into the muscle, Xeomin® causes local weakening.
- Trial name
- NCT00515944
- Testing
- Botulinum neurotoxin type A, free of complexing proteins
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Wrinkles
Comparison of Two Botulinum Toxins Type A on Forehead Wrinkles
Single-centre, controlled, randomized, evaluator-blinded, bilateral (split-face) comparison study in subjects with moderate to severe forehead wrinkles.
- Trial name
- NCT01014871
- Testing
- Botulinum Toxin Type A - Azzalure, Botulinum Toxin Type A - Vistabel
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Galderma R&D
Chronic Migraine
Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A Treatment in Chronic Migraine Patients
Preventive treatment with botulinum toxin A injections is standard care for chronic migraine and follows the PREEMPT protocol. Patients are injected at 31 locations in the frontal, corrugator and procerus muscle, the temporalis…
- Trial name
- BTACM (NCT05328687)
- Testing
- Shear wave elastography
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Danish Headache Center
Stroke
Upper Limb Training Modalities in Patients With Stroke
To date, evidence of the effects of robotic training combined with OnabotulinumtoxinA focal treatment for spasticity is limited.
- Trial name
- NCT03590314
- Testing
- Experimental group - robot assisted arm training (Armotion®), Control group - conventional treatment
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Cerebral Palsy, Spasticity
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of one or both arms alone or in combination with injections into one or both legs are effective and safe in treating…
- Trial name
- XARA (NCT02002884)
- Testing
- IncobotulinumtoxinA (8 Units per kg body weight), IncobotulinumtoxinA (6 Units per kg body weight), IncobotulinumtoxinA (2 Units per kg body weight)
- Where
- 32 sites in United States, Argentina and 4 more
- Volunteers
- 351 people
- Sponsor
- Merz Pharmaceuticals GmbH
Bruxism, Sleep
Efficacy of Botulinum Toxin and Marjoram Oil Applications in Bruxism
Objective: Bruxism is defined as clenching or grinding teeth unconsciously. It can be categorized under two subheadings: sleep and awake bruxism.
- Trial name
- NCT06674733
- Testing
- Botox administration, Aromatherapy, Clinical evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Epicondylitis, Lateral Humeral
Treatment of Tennis Elbow With Botulinum Toxin
The purpose of this study is to determine whether Botulinum A toxin is effective in the treatment of tennis elbow (lateral epicondylitis).
- Trial name
- NCT00119704
- Testing
- Botulinum toxin A injection or normal saline
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Stroke, Spasticity
Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity
The purpose of this study is to evaluate the safety and efficacy of Botulax® compared to Botox® reducing upper limb muscle tone in post stroke patients.
- Trial name
- NCT01915459
- Testing
- Botulinum toxin type A(Botulax®), Botulinum toxin type A(Botox®)
- Where
- 6 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Hugel
Facial Fine Lines
Intradermal (ID) BOTOX in the Treatment of Facial Fine Lines
The main objective of this study is to assess safety and tolerability of Intradermal (ID) BOTOX in participants with facial fine lines.
- Trial name
- NCT04631588
- Testing
- Botox
- Where
- 5 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Allergan
Cold Hypersensitivity, Vascular System Injuries
Treatment of Frostbite Sequelae With Botulinum Toxin A
Background Digital vasospasm as part of frostbite sequelae is comparable to the vasospastic disorders found in Raynaud's phenomenon which has been successfully treated with Botulinum toxin type A injections in the palm of the…
- Conditions
- Cold Hypersensitivity, Vascular System Injuries, Vibration; Disorder, Sensory Disorders
- Trial name
- NCT06460194
- Testing
- Botuinum toxin
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
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