Clinical trials: Botulinum toxin type A
Plantar Fasciitis
Phase 2 DaxibotulinumtoxinA for Injection for the Management of Plantar Fasciitis
The specific aim of the study is to compare the safety and efficacy of a single administration of DaxibotulinumtoxinA for Injection versus placebo for managing plantar fasciitis.
- Trial name
- NCT03137407
- Testing
- Botulinum Toxins, Type A
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Revance Therapeutics, Inc.
Spasticity Related to Any Cause Except Cerebral Palsy
A Study to Assess Treatment Outcomes of abobotulinumtoxinA and onabotulinumtoxinA Treatments in Real Life Practice in Toxin-naïve Adult Patients With Limb Spasticity.
The aim of the study is to describe treatment outcomes of abobotulinumtoxinA (aboBoNT-A) and onabotulinumtoxinA (onaBoNT-A) treatments, after one injection of either treatment, in toxin-naïve adult patients with upper and/or…
- Trial name
- NCT04396704
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Ipsen
Chronic Rhinosinusitis (Diagnosis)
Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis
The present work aims to assess the effectiveness and safety of topical application of BTX - A compared with its intra turbinate injection in controlling the symptoms in non infectious chronic rhinosinusitis patients
- Trial name
- NCT04572516
- Testing
- BTX A Topical, BTX A Injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Pain, Haemorriodectomy
The Effect of Botulinum Toxin Injection After Hemorrhoidectomy in Pain Control.
Hemorrhoids are a common disease in the general population. Its prevalence is estimated to be 5-36 % and more prevalent in western countries .
- Conditions
- Pain, Haemorriodectomy, Anal Sphincterotomy
- Trial name
- NCT05891314
- Testing
- Botox Injectable Product, Internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Cerebral Palsy, Muscle Contraction
The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contraction, Muscle Spasticity
- Trial name
- CPBiopsyBTX (NCT05497609)
- Testing
- no intervention. Care as ususal
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ponten
Pain
Pain Perception of Children and Youth Receiving Non-sedated Botulinum Toxin-A Injections Using the Buzzy®
The use of Botulinum toxin injections (BoNT-A) has become a standard therapy for children and youth who suffer from stiffness of their muscles due to a neurological problem.
- Trial name
- NCT02273284
- Testing
- Buzzy
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Healthy Volunteers
Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle
The primary purpose of this study is: 1. To evaluate the model determined by the ability of botulism antitoxin (bivalent, Aventis) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage…
- Trial name
- NCT00636519
- Testing
- Botulism Antitoxin Bivalent (Equine) Types A and B, Botulism Antitoxin Heptavalent (Equine) Types A-G
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Idiopathic Cervical Dystonia
UltraSound-Guided Versus Non-Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia [CUSTODY]
Cervical dystonia is a condition that causes the neck muscles to tighten or spasm, leading to abnormal head positions and pain. The main questions it aims to answer are: Do ultrasound-guided BoNT injections improve quality of…
- Trial name
- CUSTODY (NCT07233993)
- Testing
- Ultrasound-guided botulinum toxin injection, Non-ultrasound-guided botulinum toxin injection
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Painful Bladder Syndrome (PBS)
Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome
Previous clinical observations showed that Botulinum A toxin (BoNT/A) has also an antinociceptive effect and can control the neuropathic pain.
- Trial name
- NCT01157507
- Testing
- Intravesical injection of Botulinum A Toxin, Bladder overdistension
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University Of Perugia
Blepharospasm
Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm
To evaluate the efficacy of different botulinum toxin A injection patterns in treating benign essential blepharospasm and to compare their influence on condition of eye surface .
- Trial name
- NCT02327728
- Testing
- Botulinum toxin A injection (5 sites: 12.5U), Botulinum toxin A injection (4 sites: 10U), Botulinum toxin A 12.5U
- Where
- China
- Volunteers
- 120 people
- Sponsor
- YangHui
Urinary Incontinence
A Multi-Center Trial of Botox for Severe Urge Urinary Incontinence
The purpose of the study is to determine how effective Botox is in reducing the amount of urine leaked and which dose of Botox is more effective and safe in those who have urinary urge incontinence.
- Trial name
- NCT00345332
- Testing
- Botox
- Where
- 3 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Keratoconus
Botulinum Toxin A for the Treatment of Keratoconus
The purpose of this study is to associate the use of botulinum toxin type A for patients with keratoconus to demonstrate that tension eyelid has an important role in disease progression.
- Trial name
- NCT01691651
- Testing
- Subcutaneous injection of botulinum toxin type A, Botulinum Toxin Type A
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Cerebral Palsy
Which is the Best Dose of Dysport in Helping With Hip Pain for Children With Cerebral Palsy?
The purpose of the study is to compare the effectiveness of 3 doses of Dysport (5, 10 or 15 Units/Kg/hip) in the management of chronic bilateral hip pain due to cerebral palsy in children/young people.
- Trial name
- NCT00455637
- Testing
- Botulinum toxin type A
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Ipsen
Overactive Bladder
Clinical Trial to Evaluate the Efficacy and Safety of MEDITOXIN® in Subject With Idiopathic Overactive Bladder
This study is for patients who have idiopathic overactive bladder symptoms. This study will evaluate efficacy and safety of Neuronox® against placebo.
- Trial name
- NCT04113941
- Testing
- Neuronox
- Where
- South Korea
- Volunteers
- 216 people
- Sponsor
- Medy-Tox
Masseter Muscle Prominence
A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence
The masseter muscle is one of the muscles in the lower face used for chewing. The prominence of the masseter muscle can appear as a widened lower face which some individuals deem as aesthetically undesirable and can be treated by…
- Trial name
- MMP US P3 416 (NCT06387394)
- Testing
- BOTOX
- Where
- 20 sites in United States
- Volunteers
- 202 people
- Sponsor
- AbbVie
Aging
Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range
The aim of this study is to assess subjects' satisfaction linked to the pan facial management of rejuvenation with injections of Azzalure® and Restylane® fillers. This will be an open, multi-centre study.
- Trial name
- FIRST (NCT01529203)
- Testing
- Botulinum Toxin Type A (Azzalure), Restylane ranges
- Where
- 5 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Galderma R&D
Raynaud's Disease
A Two-Part Study of BOTOX® Therapy for Ischemic Digits
Treating patients with Raynaud's phenomenon who have chronic pain and ulcerations is extremely challenging. Published reports and our previous work support our hypothesis that symptomatic patients experience relief of pain and…
- Trial name
- NCT01309802
- Testing
- onabotulinum toxin type-A
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Southern Illinois University
Degenerative Rotator Cuff Disease
DEgenerative ROtator Cuff Disease and Botulinum TOXin
The aim of the study is to assess the effectiveness of botulinum toxin in persistent shoulder pain due to degenerative rotator cuff disease.
- Trial name
- DEROTOX (NCT05327972)
- Testing
- The investigational medicinal product is incobotulinumtoxinA (XEOMIN®).
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Flutter
Radiofrequency Ablation Plus Botulinum Toxin Injection Versus Radiofrequency Ablation Only in Patients With Atrial Flutter
The aim of this randomized study was to assess the effectiveness of endomyocardial botulinum toxin injection for preventing post-procedural atrial fibrillation in patients undergoing the radiofrequency ablation of atrial flutter.
- Trial name
- NCT02002962
- Testing
- radiofrequency ablation, Botulinum Toxin Type A injection
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Fecal Incontinence
Intra-rectal Botulinum Toxin Injection for Intractable Non-retentive Fecal Incontinence in Children - an Open Label Pilot Study
Background: Fecal Incontinence (FI) is a frustrating and prevalent GI condition with profound social implications and a marked effect on quality of life.
- Trial name
- NCT06785844
- Testing
- Botulinum Toxin A (Botox )
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Shaare Zedek Medical Center
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