Clinical trials: Botulinum toxin type A, completed
Obstructed Defecation, Anismus
Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients
Comparative study between surgical and non surgical treatment of anismus in patients with symptoms of obstructed defecation. Anismus is a significant cause of chronic constipation.
- Conditions
- Obstructed Defecation, Anismus, Constipation
- Trial name
- NCT00735605
- Testing
- BFD, PDPR, BTX A
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Osteoarthritis
Safety and Efficacy Study of Botulinum Toxin Type A as Treatment for Osteoarthritis Knee Pain
This study will evaluate the efficacy and safety of a single intra-articular (IA) injection of botulinum toxin Type A compared with placebo as treatment for osteoarthritis (OA) knee pain.
- Trial name
- NCT01518257
- Testing
- botulinum toxin Type A, Normal Saline
- Where
- Denmark
- Volunteers
- 121 people
- Sponsor
- Allergan
Scar, Hypertrophic Scar
The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation
1. Test the ability of botulinum toxin type A, when injected into the surgical incision at the time of surgery, to decrease postoperative scar scores compared to control (normal saline) in a double-blinded randomized control…
- Conditions
- Scar, Hypertrophic Scar, Mammary Disorder
- Trial name
- NCT03887377
- Testing
- Botulinum Toxins, Normal saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Aging
Comparative Study of the Effect of Dysport and Botox
The purpose of this study is to test the effect of Dysport and Botox on forehead wrinkles and EMG activity.
- Trial name
- NCT00434863
- Testing
- botulinum toxin type A
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laserklinik Karlsruhe
Muscle Spasticity, Stroke Sequelae
Comparison of Two Botox Injection Techniques to Improve Gait
According to our hypothesis, the use of HD-EMG shall allow an accurate localization of the innervations zones of the muscles, offering a better complement to the methodology applied so far to define the botulinum neurotoxin…
- Conditions
- Muscle Spasticity, Stroke Sequelae, Spasticity as Sequela of Stroke, Gait Disorders, Neurologic
- Trial name
- NCT07124806
- Testing
- Botulinum toxin guided by ultrasonography and anatomical references, Botulinum neurotoxin guided by ultrasonography and in vivo location of innervation zones guided by high-density electromyography
- Where
- 2 sites in Chile
- Volunteers
- 18 people
- Sponsor
- Universidad de los Andes, Chile
Glabellar Lines
Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines
The purpose of the protocol is to demonstrate the safety and the efficacy of a single injection of a new formulation of Clostridium Botulinum toxin type A haemagglutinin complex (BTX A HAC NG) to improve the appearance of…
- Trial name
- NCT02493946
- Testing
- Botulinum toxin type A
- Where
- 24 sites in France, Germany and 1 more
- Volunteers
- 600 people
- Sponsor
- Ipsen
Skin Aging
Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Lateral Canthal Lines
This is a safety and efficacy study of botulinum toxin type A in subjects with lateral canthal lines.
- Trial name
- REALISE 1 (NCT02580370)
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Revance Therapeutics, Inc.
Stroke
Upper Limb Training Modalities in Patients With Stroke
To date, evidence of the effects of robotic training combined with OnabotulinumtoxinA focal treatment for spasticity is limited.
- Trial name
- NCT03590314
- Testing
- Experimental group - robot assisted arm training (Armotion®), Control group - conventional treatment
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Benign Prostatic Hyperplasia
Effect of 50 and 100 IU Doses of Botox A Toxin Injection in BPH Patients.
The primary objective of this study is to compare the efficacy and safety of a single injection of 50 U and 100 U doses of BoNT-A for the treatment of BPH-associated LUTS.
- Trial name
- NCT02524236
- Testing
- Botox injection in the prostate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Scrotal Pain
Randomized Control Trial of the Use of Botox to Treat Chronic Scrotal Pain
There are no previous reports on the use of OnabotulinumtoxinA (Botox) to treat men with scrotal pain that we found published. We proposed a pilot study using Botox to block the nerves on a small group of men with chronic scrotal…
- Trial name
- ROBOT (NCT02249234)
- Testing
- Botox
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Mount Sinai Hospital, Canada
Glabellar Frown Lines
Treatment of Moderate to Severe Glabellar Lines
The objective of the study is to evaluate the efficacy and safety of a single dose of QM1114-DP compared to placebo for the treatment of moderate to severe GL.
- Trial name
- READY-1 (NCT04249583)
- Testing
- botulinum toxin
- Where
- 14 sites in United States, Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Botulinum Toxin, Type A
A Study of Botulinum Toxin Type A Treatment of Wrinkles in Asian
OBJECTIVES： The aim of this randomized, parallel-group, double-blinded controlled multicenter clinical trial is to determine the proper dosage of botulinum toxin type A in Asian, and provide evidence-based proof.
- Trial name
- NCT05324839
- Testing
- Botulinum toxin type A
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Stroke
Improving Holding Function of the Hemiplegic Hand
Relevant to patients with spastic hemiparesis in the hand and upper limb, this pilot project proposes to measure the effects of botulinum toxin injections through observation of performance on a functional task known as 'hand as…
- Trial name
- NCT02459951
- Testing
- clenched fist
- Volunteers
- 10 people
- Sponsor
- Nathaniel Mayer
Vocal Weakness(Post-BOTOX Injection)
Firdapse for Post-BOTOX Vocal Weakness
Botox injections into the thyroarytenoid muscle are a predictable and effective treatment for SD, but typically result in transient symptoms of voice weakness and breathiness during the first 2-3 weeks after injection.
- Trial name
- NCT05123053
- Testing
- Amifampridine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Augusta University
Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS), Cervical Dystonia
Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain
The purpose of this study is to investigate the use of injections of Botox (botulinum toxin type A) for the treatment of chronic neck pain. Botox is an approved treatment for patients with cervical dystonia.
- Trial name
- NCT00178945
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Shoulder Pain
The Treatment of Shoulder Pain in Hemiplegic Spastic Patients With Botulinum Toxin A
Stroke is the leading cause of disability in developed countries, and the major cause of mortality in Brazil.It is associated with low quality of life, disability, decreased muscle strength and control due to the hypertonia…
- Trial name
- dolomtox (NCT04470401)
- Testing
- AbobotulinumtoxinA, Saline
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Nutcracker Oesophagus
Botulinum Toxin Injection in Hypercontractile Esophagus
This study aims to evaluate the efficacy and the safety of endoscopic injection of 100 IU of botulinum toxin (BTX) in the distal esophagus in patients with symptoms related to hypercontractile esophageal motility disorders.
- Trial name
- TIBOH (NCT01955174)
- Testing
- Esophageal endoscopic injection of botulinum toxin, No injection of botulinum toxin
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Glabellar Frown Lines
Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines
This is a safety and efficacy study of DaxibotulinumtoxinA for Injection to treat moderate to severe frown lines.
- Trial name
- NCT03014635
- Testing
- Botulinum Toxins, Type A
- Where
- 14 sites in United States, Canada
- Volunteers
- 306 people
- Sponsor
- Revance Therapeutics, Inc.
Migraine
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.
- Trial name
- NCT03381261
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Neurogenic Bladder
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients
This study investigated the changes in urothelial dysfunction and sensory protein expression in the bladder urothelium with time after onabotulinumtoxin injection in spinal cord injured (SCI) patients.
- Trial name
- NCT03063827
- Testing
- OnabotulinumtoxinA 200 UNT, Urothelial sensory protein levels
- Volunteers
- 36 people
- Sponsor
- Buddhist Tzu Chi General Hospital