Clinical trials: Botulinum toxin type A
Raynaud's Syndrome
Botulinum Toxin in the Treatment of Raynaud's
The investigators are studying a medical condition known as Raynaud's Phenomenon (RP). RP is a painful condition in which cold surroundings or stressful events trigger pain, a cold sensation, and in severe cases, sores and ulcers…
- Trial name
- NCT01233999
- Testing
- botulinum toxin A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Erectile Dysfunction, Botulinum Toxin
Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction
purpose: The aim of this study is to compare the safety, efficacy and durability of different doses of BTX-A (50 and 100 unit) in the treatment of Vasculogenic Erectile Dysfunction after failure of other ICI therapy.
- Trial name
- NCT03355963
- Testing
- saline injection, Botulinum toxin type A 50 units, Botulinum toxin type A 100 units
- Volunteers
- 200 people
- Sponsor
- Benha University
Urinary Bladder, Overactive
Voiding Efficiency, a Predictor of Clean Intermittent Catheterization (CIC)
This study is a retrospective chart review of patients treated with onabotulinumtoxinA (BOTOX®) for idiopathic overactive bladder (OAB) and will determine voiding efficiency (VE) cutoff ratios that predict post-procedure urinary…
- Trial name
- NCT03043287
- Testing
- onabotulinumtoxinA
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- Allergan
Equinus Foot Deformity in Children With Cerebral Palsy
PerLE (Peroneus Longus Evaluation): A Study Evaluating the Efficacy of Injection of Dysport in Peroneus Longus in Equinus Foot Deformity in Children With Cerebral Palsy
A recent publication (Boulay et al. 2012) highlighted the role of the peroneus longus (PL) muscle in equinus foot deformity in children with hemiplegia.
- Trial name
- PerLE (NCT02856321)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Masseter Muscle Hypertrophy
Xeomin Cosmetic in the Management of Masseter
The goal of this study was to evaluate the efficacy and safety of two injection techniques in the management of masseteric hypertrophy using Xeomin Cosmetic.
- Trial name
- NCT03376464
- Testing
- Xeomin Cosmetic
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Overactive Bladder Syndrome, Urinary Urge Incontinence
Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial
Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine.
- Conditions
- Overactive Bladder Syndrome, Urinary Urge Incontinence, Detrusor Overactivity
- Trial name
- NCT07184307
- Testing
- Platelet-Rich Plasma, Intravesical Botulinum Toxin Injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Benha University
Chronic Migraine, Headache
Onabotulinumtoxin Type A Reconstitution With Preserved Versus Preservative-free Saline in Chronic Migraine.
A growing body of literature on the cosmetic use of OnabotulinumtoxinA has suggested that the use of preserved saline exerts a local anesthetic effect, and reduces the procedure discomfort when used in reconstitution in lieu of…
- Trial name
- B-RECON (NCT03698409)
- Testing
- Preserved saline in reconstitution of Botox
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- State University of New York - Upstate Medical University
Spinal Cord Injury, Neuropathic Pain
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.
- Trial name
- NCT01579500
- Testing
- Botulinum toxin type A, normal saline
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Skin Abnormalities
Fractional Co2 Laser Versus Microbotox Injection in the Treatment of Wide Facial Pores: A Split Face Comparative Study
1. Evaluation of fractional Co2 laser as a treatment option for wide pores in skin type (III - VI) 2. Evaluation of mesobotox as a new modality for improving wide pores appearance. 3.
- Trial name
- NCT05923996
- Testing
- microbotox, fractional carbon dioxide laser
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cerebral Palsy
Safety on Switching Between Different Botulinum Toxin-A
Clinical guidelines recommend the use of Botulinum Toxin-A (BoNT-A) for localized/segmental spasticity in children with cerebral palsy.
- Trial name
- NCT03234413
- Testing
- Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Nigar Dursun
Chronic Constipation
Anorectal Manometery in Pediatric Chronic Refractory Constipation
Anorectal manometry and high-resolution anorectal manometry (HRAM) are becoming the investigation of choice for understanding the pathophysiology of chronic constipation with or without fecal incontenance in children in many…
- Trial name
- NCT06543979
- Testing
- lubiprostone , single arm, biofeed back sessions, botox injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Temporomandibular Disorder
Clinical Evaluation of Botulinum Toxin a in the Management of Temporomandibular Myofascial Pain
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effectiveness of botulinum toxin type A (BoNT-A) in patients with temporomandibular myofascial pain who have not improved after…
- Trial name
- NCT07847541
- Testing
- Botulinum Toxin Type A (BoNT-A)
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Riphah International University
Myofascial Pain Syndromes
A Study of the Combination of Electrical Stimulation and Dysport® in Myofascial Pain Syndrome.
The purpose of this study is to determine whether electrical stimulation enhances the effect of botulinum toxin type A (Dysport®) on myofascial pain syndrome.
- Trial name
- NCT00246142
- Testing
- Botulinum toxin type A
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Ipsen
Gingival Recession
Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2
The goal of this study type: clinical trial] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth . Primary outcome is keratinzed tissue width.
- Trial name
- NCT06842290
- Testing
- Botulinum toxin-A injection, Coronally advanced flap
- Volunteers
- 28 people
- Sponsor
- Cairo University
Post-stroke Spasticity of the Upper Limb
TMS AND BOTULINUM TOXIN IN POST-STROKE UPPER LIMB SPASTICITY
Post-stroke upper limb spasticity is an important condition that negatively affects motor recovery, upper limb functions, and activities of daily living.
- Trial name
- TMS (NCT07624149)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Continuous Theta Burst Stimulation (cTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Asya ÖZCAN KAVCI
Hemiparesis After Stroke, Traumatic Brain Injury
Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis
The most common motor deficiency after stroke or traumatic brain injury is hemiparesis. Most hemiparetic patients recover walking, but rarely with a speed permitting easy ambulation outdoors with family or friends.
- Trial name
- GENUFLEX (NCT03119948)
- Testing
- Botulinum toxin injection
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Migraine
Real World Effectiveness of Eptinezumab in Participants With Migraine
The purpose of this study is to examine how eptinezumab compares to other advanced preventive medications in a real-world community setting in adult participants with episodic migraine (EM) or chronic migraine (CM).
- Trial name
- EVEC (NCT05284019)
- Testing
- Eptinezumab, Erenumab, Onabotulinumtoxin-A
- Where
- 10 sites in United States
- Volunteers
- 32 people
- Sponsor
- H. Lundbeck A/S
Cervical Dystonia
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in…
- Trial name
- RELY-CD (NCT05884528)
- Testing
- CC BoNT/A, CF BoNT/A, CF to CC BoNT/A
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Merz Therapeutics GmbH
Nutcracker Oesophagus
Botulinum Toxin Injection in Hypercontractile Esophagus
This study aims to evaluate the efficacy and the safety of endoscopic injection of 100 IU of botulinum toxin (BTX) in the distal esophagus in patients with symptoms related to hypercontractile esophageal motility disorders.
- Trial name
- TIBOH (NCT01955174)
- Testing
- Esophageal endoscopic injection of botulinum toxin, No injection of botulinum toxin
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
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