Clinical trials: Botulinum toxin type A, completed
Glabellar Frown Lines
Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines
This was a pilot study to observe patient satisfaction with BOTOX® Cosmetic treatment in glabellar rhytides (frown lines) using a new treatment satisfaction measure.
- Trial name
- NCT01391312
- Testing
- botulinum toxin Type A
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Allergan
Glabellar Frown Lines
IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines
IncobotulinumtoxinA (Xeomin) is a botulinum toxin type A preparation free of complexing proteins, i.e. free of proteins other than the active toxin. Injected into the muscle, IncobotulinumtoxinA (Xeomin) causes local weakening.
- Trial name
- NCT00430963
- Testing
- IncobotulinumtoxinA (Xeomin) (20 Units)
- Where
- Germany
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Migraine
Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults
This Phase 2 trial will evaluate the efficacy and safety of ABP-450 for migraine prevention in adults who suffer from six or more migraine days per month.
- Trial name
- NCT04845178
- Testing
- ABP-450
- Where
- 62 sites in United States, Australia and 1 more
- Volunteers
- 797 people
- Sponsor
- AEON Biopharma, Inc.
Moderate to Severe Glabellar Lines
Efficacy and Safety of Clostridium Botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines
The purpose of this study was to demonstrate the safety and the efficacy of a single treatment of an injectable liquid form of Clostridium botulinum toxin type A haemagglutinin complex (BTX-A-HAC; hereafter referred to as…
- Trial name
- BTX-A-HAC NG (NCT02353871)
- Testing
- Botulinum toxin type A
- Where
- 9 sites in France, Germany
- Volunteers
- 185 people
- Sponsor
- Ipsen
Glabellar Frown Lines
Safety Study of DWP-450 (Botulinum Toxin, Type a) to Treat Glabellar Lines - EV-006
The primary objective is to demonstrate the safety of multiple doses of DWP-450 purified Botulinum neurotoxin, Type A, in treatment of moderate to severe glabellar lines associated with corrugator and procerus muscle activity in…
- Trial name
- EV-006 (NCT02428608)
- Testing
- DWP-450 (Botulinum purified neurotoxin, Type A)
- Where
- United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Evolus, Inc.
Forehead/Glabellar Rhytid Complexes
Treatment of Forehead/Glabellar Rhytide Complex With Combination Botulinum Toxin A and Hyaluronic Acid Versus Botulinum Toxin A Injection Alone
The objective of this study is to determine whether the use of botulinum toxin (Dysport ®) in conjunction with a hyaluronic acid filler (Restylane®) will improve the appearance of wrinkles on the forehead and glabella (area…
- Trial name
- NCT01186835
- Testing
- Combination Botulinum Toxin A and Hyaluronic Acid, Botulinum Toxin A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Chronic Migraine
Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BOTOX®)
This study will evaluate the use of the Assessment of Chronic Migraine Impacts (ACM-I) Questionnaire in assessing the impact and benefit of treatment with onabotulinumtoxinA (BOTOX®) in adults with chronic migraine.
- Trial name
- NCT01833130
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Allergan
Vestibular Migraine
Local Sensory Nerve Block in the Treatment of Vestibular Migraine
There is no standard approach to the treatment of vestibular migraine. Agents used in the treatment of migraine are frequently used.
- Trial name
- NCT05472675
- Testing
- Botulinum toxin and bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Pamukkale University
Stroke, Upper Limb Spasticity
Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression
The purpose of this study is to investigate if early administration (i.e. within 12 weeks after stroke) of Dysport® 500 U injections may delay the appearance or the progression of upper limb symptomatic spasticity.
- Trial name
- ONTIME Pilot (NCT02321436)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Malaysia, Philippines and 2 more
- Volunteers
- 42 people
- Sponsor
- Ipsen
Facial Rhytides, Crow's Feet Lines
Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines
This study will evaluate the safety and efficacy of botulinum toxin Type A compared to placebo for the treatment of Crow's Feet Lines and Frown Lines (Facial Rhytides)
- Conditions
- Facial Rhytides, Crow's Feet Lines, Glabellar Lines
- Trial name
- NCT01189760
- Testing
- onabotulinumtoxinA 24 U, onabotulinumtoxinA 44 U, normal saline
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 917 people
- Sponsor
- Allergan
Spastic Equinovarus
Treatment of Spastic Equinovarus Foot After Stroke
This study evaluates treatment for spastic foot after stroke using ankle foot orthosis with or without selective injection of BTA (Botox).
- Trial name
- NCT00199589
- Testing
- Botulinic toxin (Botox)
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Limoges
Cerebrovascular Accident
Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing
Claw toes deformity result in spasticity often seem in patients with central nerve disease. It also cause pressure sore in foot and pain during walking that didn't well improve under traditional treatment.
- Trial name
- NCT02586142
- Testing
- Botulinum Toxin Type A, Stretching exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Sialorrhea
Botulinum Toxin Injection for Sialorrhea in Cerebral Palsy
A 100 units of botulinum toxin was injected in both parotid and submandibular glands for children (2 - 12 years) with incapacitating sialorrhea in juvenile cerebral palsy patients and they are followed up for 1 year
- Trial name
- NCT06101160
- Testing
- onaBoNT-A
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Upper Limb Spasticity Post-Stroke
Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke
This study aims to estimate the costs of botulinum toxin A utilization in standard practice for the treatment of upper limb spasticity post-stroke in Portugal.
- Trial name
- P_Dysport_CS (NCT02384330)
- Where
- 3 sites in Portugal
- Volunteers
- 57 people
- Sponsor
- Ipsen
Spasmodic Torticollis
PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia
The safety and efficacy of Mentor Purified Toxin, Botulinum Toxin Type A, Purified Neurotoxin, injected intramuscularly into the neck, is being evaluated as a treatment for painful and non-painful spasmodic torticollis/cervical…
- Trial name
- NCT00549341
- Testing
- Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin, Physiologic saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mentor Worldwide, LLC
Moderate to Severe Glabellar Line
Efficacy and Safety of DWP450 Compared With Botox in Moderate to Severe Glabellar Line
The purpose of this study was to observe Efficacy and safety of DWP450 compared with Botox in moderate to severe glabellar line patients.
- Trial name
- NCT01629875
- Testing
- Generic equivalent of Clostridium Botulinum A Toxin, Botox (Clostridium Botulinum A Toxin)
- Where
- South Korea
- Volunteers
- 268 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Urinary Bladder, Overactive, Urinary Bladder, Neurogenic
Observational Study of Botulinum Toxin Type A in Patients With Urinary Incontinence Associated With Overactive Bladder
This study will describe the prescription conditions of botulinum toxin Type A (Botox®) injection for the treatment of urinary incontinence due to neurogenic detrusor overactivity (NDO) or idiopathic overactive bladder (IOAB) as…
- Trial name
- BOREAL (NCT02673047)
- Testing
- botulinum toxin Type A
- Where
- 50 sites in France
- Volunteers
- 474 people
- Sponsor
- Allergan
Diabetes Mellitus, Neuropathic Pain
A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain
Effective treatment of neuropathic foot pain in diabetic patients is very important to improve their quality of life. There are many medications used to reduce the diabetic neuropathic pain, including anticonvulsants…
- Trial name
- NCT00336349
- Testing
- Botulinum Toxin Type A
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University Hospital
Glabellar Frown Lines
Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines
This is a safety and efficacy study of DaxibotulinumtoxinA for Injection to treat moderate to severe frown lines.
- Trial name
- NCT03014635
- Testing
- Botulinum Toxins, Type A
- Where
- 14 sites in United States, Canada
- Volunteers
- 306 people
- Sponsor
- Revance Therapeutics, Inc.
Benign Prostatic Hyperplasia
Botulinum Toxin Injection for the Management of BPH
This is a double-blind randomized phase II trial to determine whether two different doses of BoNT/A injection into the prostate gland demonstrate sufficient improvement in the management of lower urinary symptoms due to BPH to…
- Trial name
- MIST2 (NCT00451191)
- Testing
- botulinum toxin type A (BoNT/A)
- Where
- 7 sites in United States
- Volunteers
- 134 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)