Clinical trials: Botulinum toxin type A
Spasticity, Brain Injuries
CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY
Spasticity has been defined as a disorder of the sensorimotor system characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the…
- Conditions
- Spasticity, Brain Injuries, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT04673240
- Testing
- Botulinum toxin type A injection
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Plantar Fasciitis
Botulinum Toxin A Versus Steroids for the Treatment of Chronic Plantar Fasciitis
Plantar fasciitis is the classic and most common type of heel pain. Considering the costs for health care and the temporary disability not only for work, plantar fasciitis results in a substantial (and at least partially…
- Trial name
- NCT02196155
- Testing
- Botulinum toxin A, cortisone, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 54 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neuromuscular Agents, Peripheral Nervous System Agents
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States
The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence.
- Conditions
- Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs, Acetylcholine Release Inhibitors
- Trial name
- PLATINUM US (NCT07122193)
- Testing
- NT 201
- Where
- 28 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Merz North America, Inc.
Plantar Fasciitis
The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis
This single-blinded, randomized-controlled trial compares the efficacy of ultrasound-guided onabotulinumtoxinA (BTX-A) injections to the flexor digitorum brevis with current standard of care corticosteroid injections to the…
- Trial name
- NCT05367271
- Testing
- Botulinum Toxin A, Dexamethasone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Western Institute for Veterans Research
Platysma Prominence
A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence
The purpose of the study is to evaluate the safety and effects of onabotulinumtoxinA (BOTOX) for the temporary improvement in the appearance of platysma prominence.
- Trial name
- NCT04949399
- Testing
- OnabotulinumtoxinA
- Where
- 30 sites in United States, Canada
- Volunteers
- 408 people
- Sponsor
- AbbVie
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy
Painful diabetic peripheral neuropathy (DPN) is a frequent and disabling complication of diabetes that commonly causes persistent foot pain, sleep impairment, and decreased quality of life.
- Conditions
- Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy, Diabetic Foot Pain, Neuralgia
- Trial name
- NCT07882238
- Testing
- Botulinum Toxin Type A, Duloxetine
- Volunteers
- 56 people
- Sponsor
- Assiut University
Overactive Bladder Syndrome
Role of Combination Therapy in Women With Refractory Overactive Bladder
Defined by the International Continence Society (ICS) as urinary "urgency, with or without urge incontinence, usually with frequency and nocturia", overactive bladder (OAB) presents as challenging syndrome to treat.
- Trial name
- NCT06438861
- Testing
- Vibegron 75mg
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy, Drooling
Treatment of Drooling With Type A Botulinum Toxin in Children With Cerebral Palsy
The purpose of this study is to evaluate the effectiveness of botulinum toxin injection to treat drooling in children with cerebral palsy, and to find the most appropriate dosage, duration of effect and side effects.
- Trial name
- NCT00173745
- Testing
- botulinum toxin A injection
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Cervical Dystonia
IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Cervical Dystonia
At baseline patients received incobotulinumtoxinA (Xeomin) or placebo. Thereafter, all patients who entered the extension period were treated with up to five injection sessions of incobotulinumtoxinA (Xeomin) during the extension…
- Trial name
- NCT00407030
- Testing
- incobotulinumtoxinA (Xeomin) (240 Units), incobotulinumtoxinA (Xeomin) (120 Units)
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia
Neubotulinum Toxin Injection in Cerivical Dystonia
24-Week Prospective, Double-Blinded, Randomized, Cross-over design in Multicenter Study of 50 unit of Neubotulinum Toxin Type A (Neuronox) and 100 unit of Neubotulinum Toxin Type A (Neuronox) injection for Cervical Dystonia in…
- Trial name
- NTCD (NCT04582929)
- Testing
- Neuronox ® Injection
- Where
- 4 sites in Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Wrinkles
Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A
This study is being done to find out if the use of botulinum toxin prior to a medium strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid peel) will improve the appearance of crow's feet…
- Trial name
- NCT01586819
- Testing
- Botulinum Toxin, Chemical Peel Only
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Loyola University
Glabellar Lines
Safety and Efficacy of CKDB-501B in Subjects With Moderate-to-severe Glabellar Lines
A single-center, randomized, double-blind, single-injection, active-controlled, parallel-design study to evaluate the safety and efficacy of CKDB-501B in Glabellar lines.
- Trial name
- NCT05428930
- Testing
- CKDB-501B, Botox®50U
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CKD Bio Corporation
Anal Fissure Chronic
Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure
Chronic anal fissure is a common benign anorectal condition characterized by severe pain during defecation, rectal bleeding, and reduced quality of life.
- Trial name
- NCT07665528
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Botulinum Toxin Type A (BOTOX) Injection, Fissurectomy and Anoplasty
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Islamabad Medical and Dental College
Spasticity as Sequela of Stroke
Dose-response Relationship of Botullinum Toxin (DWP 450) for Finger Flexor Spasticity
Study Design: Randomized Single Blind Study Objective: To determine the dose relationship of DWP 450 for finger flexor spasticity Subjects: 78 patients with upper extremity spasticity after CVA Inclusion criteria: Patient who…
- Trial name
- NCT03517319
- Testing
- Normal Saline 0.9% 1.2 ml, Clostridium Botulinum Toxin Type A (Nabota, DWP 450) 15 U, Clostridium Botulinum Toxin Type A (Nabota, DWP 450) 30 U
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Benign Masseteric Hypertrophy
To Evaluate the Efficacy and Safety of LIZTOX in Subjects with Benign Masseteric Hypertrophy
A double-blind, randomized, placebo-controlled, multi-center, phase III study to evaluate the efficacy and safety of LIZTOX in subjects with benign Masseteric hypertrophy
- Trial name
- NCT05964257
- Testing
- Botulinum toxin type A, normal Saline
- Where
- South Korea
- Volunteers
- 188 people
- Sponsor
- Huons Biopharma
Type A Botulinum Toxin, Tennis Elbow
Comparison Between Type A Botulinum Toxin Injection and Corticosteroid Injection in the Treatment of Tennis Elbow
Humeral lateral epicondylitis or tennis elbow is a common painful elbow disorder. The cause of tennis elbow is the chronic overload of bone-tendon junction.
- Trial name
- NCT00395616
- Testing
- Botox (drug)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- E-DA Hospital
Wrinkles
Comparison of Two Botulinum Toxins Type A on Forehead Wrinkles
Single-centre, controlled, randomized, evaluator-blinded, bilateral (split-face) comparison study in subjects with moderate to severe forehead wrinkles.
- Trial name
- NCT01014871
- Testing
- Botulinum Toxin Type A - Azzalure, Botulinum Toxin Type A - Vistabel
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Galderma R&D
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Wilson Disease
The Clinical Study of Botulinum Toxin Type A Injection in the Treatment of Wilson Disease
In order to expand the treatment of Wilson disease and improve the quality of life of patients with Wilson's disease, the clinical effect of botulinum toxin type A injection on Wilson's disease was discussed.
- Trial name
- WD (NCT06762509)
- Testing
- Botulinum toxin type A
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Esophageal Cancer
Esophagectomy With or Without Prior Ischemic Gastric Preconditioning
This multi-center, randomized prospective clinical trial involves esophageal cancer patients who are surgical candidates. Patients will be randomized either to the one stage or the two stage esophagectomy procedure.
- Trial name
- NCT02457299
- Testing
- Two Stage Esophagectomy, One Stage Esophagectomy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Endeavor Health
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.