Clinical trials: Botulinum toxin type A
Stroke Sequelae, Spastic Hemiplegia
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex
The purpose of this thesis is to research the effect of oral baclofen treatment and botulinum toxin injection treatments over the electromyographic nociceptive flexor reflex (NFR) threshold in hemiplegic patients with spasticity.
- Trial name
- NCT03860662
- Testing
- Nociceptor flexor reflex, Botox, Baclofen
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Functional Popliteal Artery Entrapment Syndrome, Popliteal Artery Entrapment Syndrome
Botulinum Toxin Injection for Functional Popliteal Artery Entrapment Syndrome
Failure to adequately diagnose and treat patients with functional popliteal artery entrapment syndrome (PAES) leads to continued pain, loss of function and poor quality of life for many patients nationwide.
- Trial name
- NCT03631966
- Testing
- Dysport
- Where
- United States
- Sponsor
- Stanford University
Acne Vulgaris
Safety and Efficacy of the Use of Botox on Acne
To determine the safety and efficacy of Botox Treatment in subjects with mild to moderate acne vulgaris defined by the Investigator's Global Assessment (IGA)
- Trial name
- NCT00765375
- Testing
- Botulinum Neurotoxin Type A, Bacteriostatic saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DeNova Research
Hemifacial Paralysis
Onabotulinumtoxin A and Hyaluronic Acid Fillers in the Treatment of Facial Paralysis
Social interaction via facial mimic expression is crucial in human relationship and communication. Neural function disorder in this mechanism therefore affects human communication and social interaction.
- Trial name
- NCT05012566
- Testing
- Juvederm, Vistabex
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Glabellar Frown Lines
Safety and Efficacy Study of Botulinum Toxin Type A to Treat Glabellar Lines
The purpose of this study is to find an optimal dose to determine the safety and tolerability of a single dose of MT10109(clostridium botulinum type A) administered by intramuscular injection in subjects with glabellar lines…
- Trial name
- NCT01485601
- Testing
- MT10109
- Where
- Australia
- Volunteers
- 121 people
- Sponsor
- Medy-Tox
Androgenetic Alopecia
Efficacy of Botulinum Toxin A Versus Nanofat in the Treatment of Androgenetic Alopecia: A Comparative Clinical Trial
The goal of this clinical trial is to learn whether botulinum toxin A (BTA) or autologous nanofat injection is more effective for treating male androgenetic alopecia. It will also assess the safety of both treatments.
- Trial name
- AGA (NCT07863856)
- Testing
- Botulinum Toxin Type A, Autologous Nanofat Injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sherief Ayman Hussein Shaamash
Botulinum Toxin, Type A
A Study of Botulinum Toxin Type A Treatment of Wrinkles in Asian
OBJECTIVES： The aim of this randomized, parallel-group, double-blinded controlled multicenter clinical trial is to determine the proper dosage of botulinum toxin type A in Asian, and provide evidence-based proof.
- Trial name
- NCT05324839
- Testing
- Botulinum toxin type A
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Stroke
The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke
The purpose of this study is to see whether treating subjects for wrist rehabilitation following stroke with Botox® and robotic therapy is more effective than treatment with robotic therapy alone and no Botox®.
- Trial name
- NCT01088230
- Testing
- Botox®, saline solution
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York Presbyterian Hospital
Moderate to Severe Glabellar Frown Lines
Study to Investigate the Safety and Duration of Effect of Different Botulinum Toxin A (NT 201) Dose Groups Following the Treatment of Glabellar Frown Lines
The purpose of the study is to investigate the safety and duration of effect following different doses of Botulinum Toxin A (NT 201) in the treatment of glabellar frown lines (GFL).
- Trial name
- NCT03806933
- Testing
- NT 201
- Where
- 9 sites in United States, Germany
- Volunteers
- 241 people
- Sponsor
- Merz Aesthetics GmbH
Idiopathic Cervical Dystonia
UltraSound-Guided Versus Non-Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia [CUSTODY]
Cervical dystonia is a condition that causes the neck muscles to tighten or spasm, leading to abnormal head positions and pain. The main questions it aims to answer are: Do ultrasound-guided BoNT injections improve quality of…
- Trial name
- CUSTODY (NCT07233993)
- Testing
- Ultrasound-guided botulinum toxin injection, Non-ultrasound-guided botulinum toxin injection
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Overactive Bladder
Safety and Efficacy Study of Intravesical Instillations of BotuGelTM, Slow Release RTGel Based Botox® Formulations, in Idiopathic OAB Patients With Urinary Incontinence ("INTIMO2")
The study will investigate the safety and efficacy of UroGen's TC-3 Gel for sustained release of Botulinum Toxin A (BTX) in urinary bladder in patients with idiopathic overactive bladder.
- Trial name
- INTIMO2 (NCT02674269)
- Testing
- 300 IU of BotuGelTM (60ml), 400 IU of BotuGelTM (60ml), TC-3 Gel
- Where
- 2 sites in Israel
- Sponsor
- UroGen Pharma Ltd.
Benign Prostatic Hypertrophy (BPH), Lower Urinary Track Symptoms
Intradetrusor Onabotulinumtoxin A (Botox) at the Time of Transurethral Resection of the Prostate or Transurethral Waterjet Ablation of the Prostate for Mixed Lower Urinary Tract Symptoms
Patients with longstanding obstructive lower urinary tract symptoms (LUTS) due to benign prostatic hypertrophy (BPH) can also develop symptoms of overactive bladder syndrome (OAB).
- Trial name
- NCT07377929
- Testing
- Survey using a questionnaire.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Benaroya Research Institute
Upper Limb Spasticity
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
This study is aiming to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to…
- Trial name
- DIRECTION (NCT04936542)
- Testing
- AboBoNT-A, OnaBoNT-A
- Where
- 76 sites in United States, Canada and 2 more
- Volunteers
- 464 people
- Sponsor
- Ipsen
Spasmodic Torticollis
PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia
The safety and efficacy of Mentor Purified Toxin, Botulinum Toxin Type A, Purified Neurotoxin, injected intramuscularly into the neck, is being evaluated as a treatment for painful and non-painful spasmodic torticollis/cervical…
- Trial name
- NCT00549341
- Testing
- Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin, Physiologic saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mentor Worldwide, LLC
Obesity
Endoscopic Gastric Reduction for Weight Management
The proposed study is a prospective, pilot study to assess the feasibility of a novel endoscopic suturing system to reduce gastric volume by changing the shape of the stomach for the primary treatment of obesity.
- Trial name
- NCT01682733
- Testing
- Botulinum toxin, Overstitch Endoscopic Suturing System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Overactive Bladder Syndrome
Intravesical Injection of Botox for Treating Therapy Refractory Overactive Bladder in Females
The neurotoxin Botox (botulinum neurotoxin type A) is shown to be effective in the treatment of therapy refractory overactive bladder syndrome.
- Trial name
- NCT01042119
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Urinary Incontinence, Overactive Bladder
A Safety and Efficacy Study of Botulinum Toxin Type A (BOTOX®) to Treat Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in Korean Patients
This is a safety and efficacy study of BOTOX® (Botulinum Toxin Type A) in the Treatment of Adult Korean Patients with Urinary Incontinence due to Neurogenic Detrusor Overactivity or Overactive Bladder.
- Trial name
- NCT02601287
- Testing
- Botulinum Toxin Type A
- Where
- 5 sites in South Korea
- Volunteers
- 168 people
- Sponsor
- Allergan
Hyperhidrosis
Botulinum Toxin Treatment in Craniofacial, Inguinal, Palmar, Plantar and Truncal Hyperhidrosis
Hyperhidrosis is defined as excessive sweating and affects about 2.8 % of the population. It has been shown to have a deleterious effect on the quality of life measured using the Dermatology Life Quality Index (DLQI) which is one…
- Trial name
- NCT01930604
- Testing
- Botox (onabotulinumtoxinA), NeuroBloc/Myobloc (rimabotulinumtoxinB)
- Where
- Sweden
- Volunteers
- 588 people
- Sponsor
- Carl Swartling
Systemic Sclerosis Patients With Digital Ulcers
Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis
Efficacy and safety of local infusion of botulinum toxin type B in patients with systemic sclerosis (SSc) with digital ulcer is evaluated by a randomized, double-blind study.
- Trial name
- NCT03007004
- Testing
- Botulinum toxin type B (2500 units / vial), Physiological saline
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Gunma University
Urge Urinary Incontinence
Intravesical Instillation of Botulinum Toxin Type A to Patients With Urge Urinary Incontinence
A pilot study to examine efficacy and safety of intravesical botulinum toxin type A.
- Trial name
- NCT00770406
- Testing
- botulinum toxin type A
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Glostrup University Hospital, Copenhagen
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