Clinical trials: Botulinum toxin type A, completed
Chronic Migraine, Headaches
A Retrospective Study to Evaluate the Effectiveness and Benefit of onabotulinumtoxinA in Patients With Chronic Migraines
This study will evaluate the effectiveness and benefit of treatment with onabotulinumtoxinA in Chronic Migraine patients who have received a minimum of 7 treatment cycles.
- Trial name
- NCT01749410
- Testing
- onabotulinumtoxinA
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Allergan
Subacute Cervical Pain, Subacute Upper Back Pain
The Therapeutic Use of Botulinum Toxin Type A in Subacute Cervical/Upper Back Pain
To determine the therapeutic efficacy of Botox not only for chronic cervical/upper back pain but also for subacute pain.
- Trial name
- NCT00282958
- Testing
- Botulinum Toxin type a (Botox)
- Sponsor
- Palo Alto Veterans Institute for Research
Spasmodic Dysphonia
Spasmodic Dysphonia Pain
This study aims to identify adjuvant methods to improve patient comfort during in-office laryngology procedures.
- Trial name
- NCT04648891
- Testing
- Lidocaine, Vibrating wand
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI)
Myobloc Atrophy Study
The present pilot study is designed to assess the extent to which BOTOX and MYOBLOC cause muscle atrophy in spastic patients. The primary objective is to assess whether there is statistically significant difference in muscle…
- Conditions
- Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI), Brain Injury, Tumor
- Trial name
- MAS (NCT02052024)
- Testing
- Botox, MYOBLOC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgetown University
Gummy Smile
Effect of Clinical Crown Lengthening Surgery and Botulinum Toxin A Injection in Gummy Smile Treatment
Background: The demand for beauty is increasing in society as everyone is looking for cosmetic improvement, including gummy smile correction.
- Trial name
- NCT05057286
- Testing
- Clinical crown lengthening surgery
- Where
- Vietnam
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Idiopathic Clubfoot (Talipes Equinovarus)
A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot
The purpose of this study is to continue the work from the previous review study and determine the effectiveness of Botox in treating patients with idiopathic clubfoot by comparing outcomes of subjects treated with manipulation…
- Trial name
- NCT00152347
- Testing
- Botox
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of British Columbia
Hemiplegia and/or Hemiparesis Following Stroke
Exercise to Improve Sleep and Quality of Life in Stroke Patients Receiving Botulinum Toxin Treatment
This study aimed to investigate the contribution of aerobic exercise programmes to improving sleep quality, quality of life, and functional status, alongside conventional rehabilitation, in stroke patients who had received…
- Trial name
- NCT07369453
- Testing
- Aerobic exercise training using a cycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Essential Blepharospasm
Efficacy and Safety Study of Meditoxin® to Treat Essential Blepharospasm
The purpose of this study is to evaluate the efficacy and safety of Meditoxin® in the treatment of Essential blepharospasm.
- Trial name
- NCT01259557
- Testing
- Botulinum Toxin Type A
- Where
- 3 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- Medy-Tox
Unequal Length of Limbs; Congenital, Lower Extremity Deformities, Congenital
Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery
The purpose of this six site multi-center study is to determine if BTX-A can alleviate the post-operative pain and improve the functional and quality of life outcomes of children with limb length discrepancy or angular deformity…
- Trial name
- BOLLD (NCT00412035)
- Testing
- Botulinum toxin A injection, saline injection
- Where
- 6 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Shriners Hospitals for Children
Bladder Disorder, Neurogenic
Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Heart rate variability (HRV) is an important indicator of cardiac autonomic function and predictor of cardiac mortality and of all-cause mortality.
- Trial name
- HRV/Botox (NCT01337024)
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Amyotrophic Lateral Sclerosis, Sialorrhea
Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to determine the safety and efficacy of Myobloc in ALS patients who are having excessive drooling. The primary goal of the study is to determine if the patient perceives a benefit from the Myobloc in…
- Trial name
- NCT00125203
- Testing
- Botulinum toxin type B (Myobloc), Injection of salivary glands
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Glabellar Frown Lines
NT 201 (Xeomin®/Bocouture®) in Comparison With Clostridium Botulinum Toxin Type A in the Treatment of Glabellar Frown Lines
NT 201, also known as IncobotulinumtoxinA (Xeomin®/Bocouture®), is a Botulinum toxin type A preparation free of complexing proteins (150 kiloDalton).
- Trial name
- Head2Head (NCT00777803)
- Testing
- NT 201 (IncobotulinumtoxinA (Xeomin®/Bocouture®)), OnabotulinumtoxinA (Vistabel®)
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 381 people
- Sponsor
- Merz Pharmaceuticals GmbH
Stroke
Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity
Botulinum toxin type A (BtxA) injection and modified constraint-induced movement therapy (mCIMT) are both promising approaches to enhance recovery after stroke.
- Trial name
- NCT00723866
- Testing
- BtxA+mCIMT, BtxA+ conventional rehabilitation
- Volunteers
- 32 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Face, Skin Fold
Efficacy of Prabotulinum and Onabotulinum Toxin-A for Facial Wrinkles
The appearance of facial wrinkles, lines, or folds is a natural phenomenon during aging. Different scales help classify wrinkles objectively, such as the Facial Wrinkle Scale.
- Conditions
- Face, Skin Fold, Rejuvenation
- Trial name
- NCT05840445
- Testing
- Onabotulinum toxin A, Prabotulinumtoxin A
- Where
- 2 sites in Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Myalgia, Bruxism
Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia
Eighty individuals (44 female, 36 male), which were randomly divided into 4 groups of 20 patients each, due to the treatment type: Botulinum toxin (BTX); Dry needling (DN); Pharmacological therapy (PT) and Manual therapy (MT).
- Conditions
- Myalgia, Bruxism, Quality of Life
- Trial name
- NCT06583551
- Testing
- Botulinum toxin, Dry needling, Myorel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Osteoarthritis, Knee
Is Botox Effective in Relieving Pain From Knee Osteoarthritis?
Patients with painful knee osteoarthritis will be randomly allocated to one of three groups. Each group will receive a knee injection of: 1) cortisone, 2) low dose Botox, or 3) high dose Botox.
- Trial name
- NCT00279903
- Testing
- Botulinum toxin type A (Btx-A), Cortisone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Glabellar Frown Lines
Finding of Optimal Dose for NT 201 in the Treatment of Glabellar Frown Lines
NT 201 is a botulinum toxin type A preparation free of complexing proteins, i.e. free of proteins other than the active toxin. Injected into the muscle, NT 201 causes local weakening to full paralysis depending on the…
- Trial name
- NCT00430586
- Testing
- Botulinum neurotoxin type A, free of complexing proteins
- Where
- Germany
- Volunteers
- 191 people
- Sponsor
- Merz Pharmaceuticals GmbH
Esophageal Carcinoma
Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer
This randomized phase II trial studies how well botulinum toxin type A works in preventing complication after surgery in patients with esophageal cancer.
- Trial name
- NCT02965976
- Testing
- Botulinum Toxin Type A, Esophagectomy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Roswell Park Cancer Institute
Glabellar Frown Lines
Treatment of Moderate to Severe Glabellar Lines
The objective of the study is to evaluate the efficacy and safety of a single dose of QM1114-DP compared to placebo for the treatment of moderate to severe GL.
- Trial name
- READY-1 (NCT04249583)
- Testing
- botulinum toxin
- Where
- 14 sites in United States, Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Upper Limb Spasticity
Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity
This is a randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Ranging, trial to Evaluate the Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Upper Limb Spasticity in Adults After…
- Trial name
- JUNIPER (NCT03821402)
- Testing
- DAXI for injection 250 U, DAXI for injection 375 U, DAXI for injection 500 U
- Where
- 26 sites in United States
- Volunteers
- 83 people
- Sponsor
- Revance Therapeutics, Inc.