Clinical trials: Botulinum toxin type A
Cutaneous Leiomyomas, Hereditary Leiomyomatosis and Renal Cell Cancer
Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin
Cutaneous leiomyomas are benign tumors of smooth muscle origin. They can be very painful, and current treatments for the tumors and for the associated pain do not produce satisfactory results.
- Trial name
- NCT00971620
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Trigeminal Neuralgia
Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia
This is a double-blind randomized clinical trial comparing the pain reduction of individuals treated with BTX-A and placebo as well as evaluating possible changes in neuroinflammatory biomarkers.
- Trial name
- NCT06315790
- Testing
- Botulinum toxin A, Isotonic saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Henrik Schytz
Glabellar Frown Lines
A Safety and Efficacy Study of Different Injections Volumes of Botulinum Toxin Type A, Azzalure, in the Glabellar Lines
A randomized, evaluator-blinded, comparative, study to evaluate the efficacy and safety of different injection volumes of botulinum toxin type A, Azzalure, in the glabellar lines.
- Trial name
- NCT02108158
- Testing
- Azzalure
- Where
- 2 sites in Sweden
- Volunteers
- 62 people
- Sponsor
- Galderma R&D
Brow Lifting
The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial
The purpose of this study is to describe three safe and reproducible techniques for brow lifting using botulinum toxin. It will also describe the effect of 2 techniques on the eyebrow shape using quantitative, objective…
- Trial name
- NCT02942303
- Testing
- Dysport, lateral orbicularis injection, Lateral orbicularis + corrugator injection
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- St Joseph University, Beirut, Lebanon
Stroke, Pain
Botulinum Toxin A for Shoulder Pain After Stroke
Shoulder pain after stroke is a very common, causing significant morbidity disease. Subacromial and subdeltoid (SASD) bursitis are common causes of pain or disability of the shoulder joint in stroke patients.
- Trial name
- NCT02618603
- Testing
- Botulinum toxin A, Triamcinolone Acetonide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Parkinson Disease, Depression
Trial of OnabotulinumtoxinA for Depression in Parkinson Disease
This study evaluates the efficacy of onabotulinumtoxinA (BOTOX®) in the treatment of depression associated with Idiopathic Parkinson Disease in adults.
- Trial name
- NCT03069911
- Testing
- OnabotulinumtoxinA, Control
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Moderate to Severe Glabellar Lines
A Phase I/II Study of Recombinant Botulinum Toxin Type A for the Treatment of Moderate to Severe Glabellar Lines
This is a phase 1/2, multicenter, randomized, double-blind, active-controlled and placebo-controlled study to evaluate safety,immunogenicity and efficacy of YY001 for the treatment of moderate to severe glabellar lines in male…
- Trial name
- NCT05743634
- Testing
- YY001, OnabotulinumtoxinA
- Where
- 6 sites in China
- Volunteers
- 140 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Idiopathic Clubfoot (Talipes Equinovarus)
Efficacy of Botox in Patients With Idiopathic Clubfoot
The purpose of this study was to determine the efficacy of adding Botox injection to serial manipulations and castings in patients with clubfoot.
- Trial name
- NCT00152334
- Testing
- Botox
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Cerebral Palsy, Spastic
Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy
This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy
- Trial name
- NCT06494618
- Testing
- Radial Extracorporeal Shockwave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medeniyet University
Gingival Recession
Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2
The goal of this study type: clinical trial] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth . Primary outcome is keratinzed tissue width.
- Trial name
- NCT06842290
- Testing
- Botulinum toxin-A injection, Coronally advanced flap
- Volunteers
- 28 people
- Sponsor
- Cairo University
Neuropathic Pain
Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain
Onabotulinum toxin type A (BoNT-A) is a potent neurotoxin that has been reported to have an effect on afferent (sensory) neurons independent of its action on muscle tone and secretory glands at the periphery.In human studies, the…
- Trial name
- NCT03848143
- Testing
- onabotulinum toxin A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Isabel Moreno Hay
Spasticity
Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticity
The purpose of this study is to compare the effectiveness between two commercial formulations of botulinum toxin type A in the treatment of spasticity through the Ashworth scale.
- Trial name
- NCT00819065
- Testing
- Botulinum toxin type A from laboratory Lanzhou, Botulinum toxin type A from laboratory Allergan
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Blepharospasm
Blepharospasm Short Interval
The objective of this Phase II study is to show that pre-treated patients with BEB with the need of shortened injection intervals achieve an improved and stable quality of life level if they receive repeated NT 201 injections at…
- Trial name
- NCT00507637
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Merz Pharmaceuticals GmbH
Pediatrics, Muscle Spasticity
BOTOX® Treatment in Pediatric Lower Limb Spasticity
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) in pediatric patients with lower limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy
- Trial name
- NCT01603628
- Testing
- botulinum toxin Type A
- Where
- 53 sites in United States, Hungary and 7 more
- Volunteers
- 384 people
- Sponsor
- Allergan
Chronic Brain Injury, Cerebral Stroke
Qualitative Study Patient & Physician Experiences Botox COVID-19
During the COVID-19 pandemic and subsequent series of Lockdowns, clinic out-patient spasticity services were replaced with video based tele-consultation appointments, in order to reduce the potential risk of virus transmission…
- Conditions
- Chronic Brain Injury, Cerebral Stroke, MS (Multiple Sclerosis)
- Trial name
- QualBotoxCov (NCT05435404)
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Chronic Anal Fissure
Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- BTATCAF (NCT05598164)
- Testing
- Botulinum toxin type A
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Freezing of Gate, Parkinson Disease
Effectiveness of Botulinum Toxin in Freezing of Gate in Parkinson's Disease Walking in Parkinson's Disease.
Freezing of gait is a symptom of Parkinson's disease (PD) that becomes more evident with the evolution of the disease, and which presents an important difference compared to the other signs and symptoms: does not respond…
- Conditions
- Freezing of Gate, Parkinson Disease, Botulinum Toxin
- Trial name
- NCT06094309
- Testing
- Botulinum toxin type A injection
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Glabellar Frown Lines
Efficacy and Safety Study of MT10107 in the Treatment of Glabella Line
This study design is a parallel, active drug controlled, double blind, randomized, multi-centered, phase III clinical trial to compare the efficacy and safety of MT10107 versus BOTOX® in treatment of glabella line.
- Trial name
- NCT03908008
- Testing
- Botox (Botulinum toxin type A), MT10107 (Botulinum toxin type A)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Medy-Tox
Stress Urinary Incontinence
Feasibility of BOTOX Injection on Improving Female Stress Urinary Incontinence
The purpose of this study is to assess the effect of onabotulinumtoxin A (BOTOX) injection into the detrusor muscle on increasing bladder compliance to reduce urinary leakage in women suffering from stress urinary incontinence…
- Trial name
- NCT04984317
- Testing
- onabotulinumtoxin A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
HIV Posterior Cheek Enlargement
HIV Posterior Cheek Enlargement
Altered contour of the lower face is a frequent complication of human immunodeficiency virus (HIV). HIV facial lipoatrophy or loss of facial fat commonly results from antiretroviral therapy.
- Trial name
- NCT01635504
- Testing
- Botulinum toxin A
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
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