Clinical trials: Botulinum toxin type A
Cervical Dystonia
Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
To determine the efficacy and safety of Botulax® in treatment of cervical dystonia
- Trial name
- NCT04171258
- Testing
- Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hugel
Overactive Bladder, Urinary Urge Incontinence
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
The purpose of this study is to test whether using belladonna \& opiate suppositories (B\&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
- Trial name
- ROBIN (NCT02600715)
- Testing
- Onabotulinumtoxin A (BoNT), belladonna, Morphine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Edgar LeClaire, MD
Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids
Upper Facial Remodeling With Perlane-L and Dysport
The purpose of this study is to provide data to support combination treatment of the upper face with Perlane-L® and Dysport™. This study will assess the outcome of upper face rejuvenation in the temporal fossa; outcome of…
- Conditions
- Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
- Trial name
- DPL-2010 (NCT01354743)
- Testing
- Dysport, Perlane L
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beer, Kenneth R., M.D., PA
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
Essential Tremor of the Upper Limb
A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm
The purpose of this study is to determine whether a single treatment with NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the motor-dominant arm (Unilateral Period).
- Trial name
- NCT04766723
- Testing
- NT 201
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- Merz Pharmaceuticals GmbH
Glabellar Lines
A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
- Trial name
- NCT06834789
- Testing
- AGN-151586, OnabotulinumtoxinA
- Where
- 8 sites in United States
- Volunteers
- 132 people
- Sponsor
- AbbVie
Skin Aging
Efficacy and Safety of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will confirm the efficacy and safety of a single topical administration of botulinum toxin type A compared to placebo control for the treatment of moderate to severe crow's feet lines
- Trial name
- NCT01940991
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Revance Therapeutics, Inc.
Proctalgia
Analgesic Effect of an Injection of Botulinum Toxin Type A in the Ganglion Impar in Patients With Chronic Proctalgia
The main objective is to evaluate the analgesic efficacy of botulinum toxin type A in refractory chronic proctalgia one month after a bilateral injection of 50 units of Botox ® in the ganglion Impar (total dose = 100 units)
- Trial name
- Impartox (NCT01331356)
- Testing
- Botox
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Nantes University Hospital
Arthritis Multiple Joint
Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint
Basal arthritis of the thumb is a common condition with increased prevalence in post-menopausal women, obese persons, and the elderly. Surgical options are varied and efficacious, but not all patients are candidates for surgery.
- Trial name
- NCT01045694
- Testing
- Botulinum Toxin Type A, Steroid - Triamcinolone Acetonide, Lidocaine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Glabellar Frown Lines
Depth of Botulinum Neurotoxin Injection for Treatment of Glabellar Lines
STUDY QUESTION: Does the depth of injection of onabotulinumtoxinA neurotoxin in the glabellar complex affect efficacy of the BoTN for the improvement of glabellar frown lines? STUDY AIM Primary objective: Compare the efficacy of…
- Trial name
- NCT05766683
- Testing
- onabotulinumtoxinA at a depth of 2mm, onabotulinumtoxinA at a depth of 4mm
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Oromandibular Dystonia, Electromyography
Botulinum Toxin A for Jaw Dystonia .
This study evaluates the effectiveness and safety of Electromyography (EMG)-guided Botulinum Toxin type A (BTX-A) injections in treating oromandibular dystonia (OMD) among a sample of Yemeni patients.
- Trial name
- OMD _ BTX-A (NCT07792798)
- Testing
- Botulinum Toxin Type A (BOTOX) Injection
- Where
- Yemen
- Volunteers
- 20 people
- Sponsor
- Sana'a University
Epicondylitis, Lateral Humeral, Tennis Elbow
Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia
The primary objective of this study is to compare the evolution of pain profiles among patients suffering from lateral epicondyalgia (tennis elbow) following three types of treatment: PRP-L injection versus type A botulinum toxin…
- Trial name
- LET (NCT02325063)
- Testing
- PRP-L Injection, Botox injection, Corticoid injection
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Glabellar Rhytides
A Long-Term Safety Study of Repeat Treatment With PurTox® for Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the long-term safety of repeat treatment with an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines.
- Trial name
- PT-03c (NCT00752258)
- Testing
- Mentor Purified Toxin Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- Mentor Worldwide, LLC
Headache, Allodynia
Botulinum Toxin Type A in Treatment of Cranial Allodynia in Patients With Headache
The objective of this study is evaluated if the Botulinum Toxin Type A is superior to 0,9% saline in treatment of cranial Allodynia in patients with headache.
- Trial name
- NCT01357798
- Testing
- Botulinum toxin type A, 0,9% saline
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
Chronic Pain, Neuroma
Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Conditions
- Chronic Pain, Neuroma, Botulinium Toxin-A, Combat Trauma
- Trial name
- IN-PERI NEUROM (NCT07624877)
- Testing
- Botulinum toxin type A injection
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Sternotomy Closure,Open Heart Surgery
Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact
Sternotomy scars, which are localized in a high-tension area are often dystrophic, hypertrophic or keloidal, and can be difficult to accept to patients who already endured a heavy intervention with high psychologic impact.
- Trial name
- BotuCiSter (NCT07013240)
- Testing
- Botulinum toxin injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Painful Bladder Syndrome, Interstitial Cystitis
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension.
- Trial name
- NCT00194610
- Testing
- Botox, normal saline
- Volunteers
- 20 people
- Sponsor
- University of Washington
Wrinkles in Frontal Area
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the field of effects of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00989768
- Testing
- Botulinum Toxin Type A (Dysport®), Botulinum Toxin Type A/Botox®, Botulinum Toxin Type A/Dysport®
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Glabellar Lines
A Study of OnabotulinumtoxinA X Injection in Adult Participants With Glabellar Lines
Hyperfunctional facial lines that develop from repeated facial expression, such as glabellar lines (GL), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin.
- Trial name
- NCT05013424
- Testing
- Formulation A: OnabotulinumtoxinA, Formulation B: OnabotulinumtoxinA, Formulation C: OnabotulinumtoxinA
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- Allergan
Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI)
Myobloc Atrophy Study
The present pilot study is designed to assess the extent to which BOTOX and MYOBLOC cause muscle atrophy in spastic patients. The primary objective is to assess whether there is statistically significant difference in muscle…
- Conditions
- Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI), Brain Injury, Tumor
- Trial name
- MAS (NCT02052024)
- Testing
- Botox, MYOBLOC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgetown University
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