Clinical trials: Bupivacaine
Appendicitis Acute
Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult
Acute appendicitis is one of the most common acute abdomens that need surgical intervention. Laparoscopic surgery much decreases postoperative pain of wound, however, pain remains an important determinant of recovery after…
- Trial name
- NCT03481517
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Taiwan University Hospital
Opioid Consumption, Postoperative
Postoperative Opioid Consumption of Serratus Posterior Superior Intercostal Plane Block Versus Thoracic Paravertebral Block
Previous studies found that paravertebral and thoracic epidural continuous infusions of opioid-free local anaesthetic were found to be comparable, but paravertebral analgesia (PVA) was associated with less respiratory…
- Trial name
- NCT07613697
- Testing
- Serratus Posterior Superior Intercostal Plane Block (single injection), Thoracic Paravertebral block (single injection)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Pain
ACL Repair and Multimodal Analgesia
This study will evaluate the effectiveness of an aggressive multimodal regimen versus standard multimodal for Anterior Cruciate Ligament (ACL) repair using hamstring graft for patients having surgery in our outpatient surgicenter.
- Trial name
- NCT01868425
- Testing
- multimodal:acetaminophen, gabapentin, ketamine, bupivacaine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Wisconsin, Madison
Video-assisted Thoracoscopic Surgery (VATS), Serratus Posterior Superior Intercostal Plane Block
ESP vs SPSIP Block in VATS Analgesia
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive procedure performed through small thoracic incisions, but postoperative pain remains significant due to tissue and rib trauma.
- Trial name
- NCT07232940
- Testing
- Postoperative analgesia management(SPSIPB), Postoperative analgesia management(ESPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Hand Surgery
Effect of Verapamil as an Adjuvant to Local Anaethetics in Supraclav Block for Hand Surgery
The aim of this study is to evaluate the role of verapamil when added to bupivacaine in ultrasound-giuded supraclavicular Brachial plexus block regarding the duration of action of the block, onset of action and the need of rescue…
- Trial name
- NCT06847620
- Testing
- Supraclavicular Brachial Plexus Block, Bupivacaine 0.25% 20ml alone, bupivacaine 0.25% And verapamil
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain
ED90 of 0.75% Bupivacaine for Bilateral Tubal Ligation (BTL)
The purpose of this study is to determine the dose of bupivacaine that provides effective pain management in 90% (ED90) of patients undergoing bilateral tubal ligation.
- Trial name
- NCT05017584
- Testing
- Hyperbaric bupivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Kidney Transplant
Erector Spınae Plane Block and Transmuscular Quadratus Lumborum Block In Kıdney Transplantatıon
Perioperative anesthesia and pain management are among the difficult situations for anesthesiologists to manage in kidney transplant patients.
- Trial name
- NCT07059455
- Testing
- Erector Spinae (ESP) Block with Bupivacaine (Marcaine®), Quadratus Lumborum (QL) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Anesthesia
Surgical Pleth Index- Relevance in Small Children
Surgical Pleth index is a novel device aimed for measurement of intraoperative nosiseption. It has not been tested on small children.
- Trial name
- SPIinChildren (NCT02045810)
- Testing
- Levobupivacaine, Saline
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Immune Suppression
The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.
General anesthesia has an important effect on inflammatory cytokines. Inhalational agents as isoflurane and sevoflurane attenuate immune function expressed by neutrophil chemoattractant-1 as well as inflammatory enzyme and also…
- Trial name
- NCT03437213
- Testing
- Total intravenous anesthesia group, Total intravenous plus block group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alaa Mazy Mazy
Hip Fractures
Enhancing Recovery in Hip Fracture Surgeries
The purpose of this study is to look at how two different types of anesthesia, spinal and general, affect participants with broken hips who are getting a special kind of pain block before surgery.
- Trial name
- NCT06249789
- Testing
- Spinal Anesthesia, General Anesthesia
- Volunteers
- 102 people
- Sponsor
- Hartford Hospital
Pain, Acute
Optimal Timing of Parasternal Intercostal Nerve Block Application for Acute Pain Management in Cardiac Surgery
Patients experiencing pain after undergoing cardiac surgery may also experience prolonged immobilization, insufficient respiratory functions, and the inability to cough due to median sternotomy.
- Trial name
- NCT05363540
- Testing
- pre-incisional parasternal intercostal block, post-incisional parasternal intercostal block
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Benha University
Anaesthesia
Comparing Post-operative Analgesia After (PECS II) Block and (ESPB) in Modified Radical Mastectomy
The aim of this study is to compare the analgesic efficacies of the modified pectoral plane block (PECS II) and the erector spinae plane block (ESPB) after modified radical mastectomy surgery through assessment of post-operative…
- Trial name
- NCT06714682
- Testing
- Modified Pectoral Plane block group, Erector spinae plane block group.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Surgical Procedures, Operative
The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.
Animal studies suggest general anaesthetics harm the developing brain. It is unclear if these findings are relevant to humans but the issue has become a major concern.
- Trial name
- NCT02353182
- Testing
- Dexmedetomidine, Remifentanil, Bupivacaine
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 60 people
- Sponsor
- Murdoch Childrens Research Institute
Emergence Agitation, Postoperative Pain
Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.
Sevoflurane is the agent of choice for induction and maintenance of day care anesthesia in children and has a wide acceptance among pediatric anesthesiologists.
- Trial name
- NCT03846284
- Testing
- Bupivacaine, Magnesium sulfate 50mg, Magnesium sulfate 30 mg
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Mansoura University
Malignant Melanoma
Anesthesia and Cancer Recurrence im Malignant Melanoma
Studies in animals and retrospective studies in humans show that regional anesthesia reduces metastatic cancer dissemination. The investigators hypothesize that in patients suffering from malignant melanoma who have to undergo…
- Trial name
- NCT01588847
- Testing
- Spinal anesthesia with Bupivacaine hyperbar 0.5 %, General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane
- Where
- Germany
- Volunteers
- 230 people
- Sponsor
- University Hospital Muenster
Pelvic Organ Prolapse (POP), Postoperative Pain
Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension
This study is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of paracervical block on early postoperative pain after vaginal natural orifice transluminal endoscopic…
- Trial name
- vNOTES-PB (NCT07440576)
- Testing
- Bupivacaine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Erkan Gol
Postoperative Pain
Decreasing Postoperative Pain Following Endometrial Ablation
To determine whether paracervical injection of long acting local anesthesia decreases postoperative pain following endometrial ablation under general anesthesia.
- Trial name
- NCT02660918
- Testing
- Bupivacaine, Normal Saline
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Obstetric Pain, Labor Pain
Dural Puncture Epidural VS Standard Epidural on Physician Top-ups During Labour Analgesia
The purpose of this prospective randomized controlled study is to compare the number of physician top-up interventions during the first stage of labour between two different neuraxial analgesia techniques : the dural puncture…
- Conditions
- Obstetric Pain, Labor Pain, Anesthesia
- Trial name
- DPE (NCT04728048)
- Testing
- Dural puncture epidural, Standard epidural
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cesarean Section Complications
Effect of a 20% Reduction in Hyperbaric Bupivacaine Dose on High Spinal Block Incidence in Cesarean Delivery
Effect of a 20% Reduction in Hyperbaric Bupivacaine Dose on High Spinal Block Incidence in Cesarean Delivery: A Risk-Stratified Randomized Controlled Trial.
- Trial name
- NCT07140640
- Testing
- Hyperbaric Bupivacaine HCl 0.5% 12.5 mg, Hyperbaric Bupivacaine HCl 0.5% 10 mg
- Where
- Egypt
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Aswan University
Obesity
Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia
Post-laparoscopic sleeve pain management is essential for early mobilization of the patient and so on decrease post-operative complication.
- Trial name
- NCT04525274
- Testing
- normal saline, dexmedetomidine, Ketamine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
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