Clinical trials: Bupivacaine
Patients Eligible for Elective Lower Extremity Femoral Nerve Surgery, Knee Arthroscopic Surgery
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
This prospective, sequential dose-finding clinical observational study aims to estimate the median effective concentration (EC50) and the 95% effective concentration (EC95) of liposomal bupivacaine for ultrasound-guided femoral…
- Trial name
- NCT07366905
- Testing
- Liposomal bupivacaine, 266mg
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Hainan Medical College
Postoperative Pain, Liposomal Bupivacaine
Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block
This is a single-center, randomized, single-blind, parallel-group clinical trial. The study aims to compare the analgesic efficacy of liposomal bupivacaine versus ropivacaine for transversus abdominis plane (TAP) block in…
- Trial name
- NCT07577934
- Testing
- Liposomal Bupivacaine TAP block, Ropivacaine TAP blocks
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin First Central Hospital
Video-Assisted Thoracic Surgery
Quality of Postoperative Recovery (QoR-15T) in Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique that provides faster recovery after thoracic surgery.
- Trial name
- NCT06558331
- Testing
- Bupivacaine 0,25%, Bupivacaine 0,375%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Analgesia
Inter-semispinal Fascial Plane Block (ISPB) Versus Erector Spinae Plane Block (ESPB) in Posterior Cervical Spine Surgery
Recent advances in regional anesthesia techniques have aimed to provide more targeted and effective pain relief. Among these, the erector spinae plane (ESPB) block, the multifidus cervicis plane (MCP) block, and the paraspinal…
- Trial name
- NCT07340801
- Testing
- Bupivacaine
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery
The study aims to test the safety and effectiveness of two different surgeon-administered methods of the anesthesia medication EXPAREL during knee replacement surgery.
- Trial name
- CRS-121 (NCT07584915)
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Analgesia
Pediatric Postoperative Analgesia Herniorrhaphy Study
This is a Phase 2 study in pediatric subjects undergoing inguinal herniorrhaphy.
- Trial name
- NCT03922048
- Testing
- HTX-011, Bupivacaine HCl, Luer Lock Applicator
- Sponsor
- Heron Therapeutics
Inguinal Hernia Postoperative Pain Acute Pain
The Effect of Different Volumes of Ilioinguinal-Iliohypogastric Nerve Block on Postoperative Analgesia in Inguinal Hernia Surgery
The primary objective of this study is to evaluate and compare the efficacy of different volumes of local anesthetics, administered at the same total dose, for ilioinguinal and iliohypogastric (II/IH) nerve blocks in patients…
- Trial name
- NCT07579975
- Testing
- Bupivacaine (Ilioinguinal-iliohypogastric nerve block)
- Volunteers
- 70 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Regional Anesthesia, Postoperative Pain
US-guided Pericapsular Nerve Group (PENG) Block in Different Volumes on Postoperative Pain in Hip Replacement Surgeries
Postoperative pain management has an important place in anesthesia practices. In order to ensure patient comfort after the surgery, to start postoperative rehabilitation early, and to prevent the process from causing mood…
- Conditions
- Regional Anesthesia, Postoperative Pain, Hip Surgery
- Trial name
- NCT06166602
- Testing
- PENG block with 0.25% bupivacaine.
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Cough
Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough
The purpose of this study is to evaluate if office-based injection of a local anesthetic/steroid combination at the area of one superior laryngeal nerve can decrease cough frequency and alleviate symptoms of chronic cough in…
- Trial name
- NCT04642352
- Testing
- superior laryngeal nerve block
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Menstrual Migraine, Menstrually Related Migraine
Repetitive GON Blockade for Menstrual Migraine
: The primary objective of this prospective, randomized, double-blind, placebo-controlled clinical trial is to evaluate whether repetitive bilateral greater occipital nerve (GON) blockade administered with a local anesthetic…
- Trial name
- NCT07576309
- Testing
- 0.5% bupivacaine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Perioperative Analgesia
Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries
This study will evaluate the effect of adding dexmedetomidine to bupivacaine compared to ketamine in the caudal block on perioperative analgesia in patients undergoing lumbosacral surgeries under general anesthesia.
- Trial name
- NCT07573969
- Testing
- Group C (plain bupivacaine (0.125%)), Group D (plain bupivacaine (0.125%) + 2μg/kg dexmedetomidine), Group K (plain bupivacaine (0.125%) + 1mg/kg ketamine)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Hallux Valgus, Bunionectomy
Sciatic Nerve Block With ALX006 in Subjects Undergoing Bunionectomy
This is a Phase 2, randomized, double-blind, active-controlled, dose-escalation study evaluating the safety, pharmacokinetics, efficacy, and pharmacodynamics of ALX006, an extended-release bupivacaine formulation, administered as…
- Trial name
- NCT07574385
- Testing
- ALX006 (bupivacaine extended-release injection), Bupivacaine Hcl 0.25% Inj, Sciatic Nerve Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rebel Medicine Inc
Pain, Postoperative
Video-assisted Thoracoscopic Surgery - Exparel Study
Video-assisted thoracoscopic surgery (VATS) greatly decreased the number and types of surgery that required open thoracotomy. Initially it was thought that VATS would lead to a reduction of respiratory problems and less acute…
- Trial name
- NCT04864210
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Nada Sadek
Appendectomy, Pediatric
The Effectiveness of Dexmedetomidine as an Adjuvant for Bupivacaine Caudal Block in Pediatric Open Appendectomy Under General Anesthesia
This study aims to evaluate if adding dexmedetomidine to bupivacaine in a caudal block can provide longer and better quality pain relief for children after open appendectomy surgery.
- Trial name
- NCT07088900
- Testing
- caudal block using dexmedetomidine with bupivacaine, caudal block with bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Sphenopalatine Ganglion Block, General Anesthesia
Sphenopalatine Ganglion Block as Adjuvant to General Anesthesia Regarding the Quality of Surgical Field in Trans-Sphenoidal Endoscopic Hypophysectomy
This study aims to evaluate the efficacy of ultrasound guided sphenopalatine ganglion block (SPGB) through the suprazygomatic approach in optimizing the quality of surgical field as well as its effect on postoperative pain relief…
- Conditions
- Sphenopalatine Ganglion Block, General Anesthesia, Quality of Surgical Field, Trans-Sphenoidal Endoscopic Hypophysectomy
- Trial name
- NCT07569952
- Testing
- Sphenopalatine ganglion block using bupivacaine + dexamethasone, General anesthesia
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Post Operative Analgesia, Hemodynamic (MAP) Stability
Comparative Study of USG Guided ESPB vs USG Guided PVB For Post-op Analgesia In Patient's After Open Renal Surgeries
Pain control following open renal surgeries are of utmost importance in order to reduce the chance of chronic pain development, and facilitate early rehabilitation.
- Conditions
- Post Operative Analgesia, Hemodynamic (MAP) Stability, Renal Surgeries, Hypertension
- Trial name
- NCT06728514
- Testing
- Erector spinae plane block group., Paravertebral Nerve Block, Inj Bupivacaine
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sahiwal medical college sahiwal
Postoperative Shivering
Spinal Anesthesia With Bupivacaine Versus Prilocaine on Postoperative Shivering After Inguinal Hernia Repair
Effect of spinal anesthesia with bupivacaine versus prilocaine on postoperative shivering after inguinal hernia repair : a prospective randomized double blind study
- Trial name
- NCT07564180
- Testing
- Bupivacaine Spinal Anesthesia, Prilocaine spinal anesthesia, Spinal Anesthesia (bupivacaine) spinal anesthsia (prilocaine)
- Volunteers
- 80 people
- Sponsor
- Amr mohamed
Third Molars Extraction
Comparative Experimental Study Between Bupivacaine and Ropivacaine Regarding Efficacy in Third Molar Removal Surgery Under General Anesthesia
The goal of this clinical trial is to compare the efficacy of bupivacaine and ropivacaine in third molar removal surgery under general anesthesia in healthy volunteers.
- Trial name
- NCT07108465
- Testing
- Bupivacaine 0,5%, Ropivacaine 0,75%
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henrique Tedesco
Post Cesarean Section Pain
Optimal Intrathecal Morphine Dose for Better Post Cesarean Section Analgesia
Central neuraxial blocks (CNBs) remain the preferred anesthetic technique for cesarean section, with single shot spinal anesthesia (SSSA) being the standard practice at investigator's institute unless contraindicated.
- Trial name
- Analgesia (NCT07560501)
- Testing
- 0.5% bupivacaine heavy with fentanyl, 0.5% bupivacaine heavy with fentanyl plus morphine 50 mcg, 0.5% bupivacaine heavy with fentanyl plus morphine100 mcg
- Volunteers
- 180 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Ankle Fractures
Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
The investigators plan to evaluate the efficacy in reducing post-operative pain between local multimodal analgesia as compared to regional anesthesia in rotational ankle fractures.
- Trial name
- NCT05019638
- Testing
- Regional anesthesia group, Local multimodal analgesia group
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah