Clinical trials: Bupivacaine
Postoperative Pain
Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty
This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block…
- Trial name
- DSG-PENG (NCT07770932)
- Testing
- 0.25% Bupivacaine for Deep Subgluteal Block, 0.25% and 0.125% Bupivacaine for PENG+LFCN Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Postoperative Care
Efficacy of Liposomal Bupivacaine Scalp Nerve Block for Postoperative Pain Management After Supratentorial Craniotomy
This is a prospective, randomized, controlled trial conducted at Beijing Tiantan Hospital to evaluate the efficacy and safety of liposomal bupivacaine for scalp nerve block in managing postoperative pain after elective…
- Trial name
- NCT07344181
- Testing
- Preoperative scalp nerve block
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Beijing Tiantan Hospital
Labor Pain, Obstetric Pain
Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia
Epidural Analgesia remains the most effective form of pain relief in labour. After initiating epidural analgesia, there are many epidural drug regimens that can be employed to maintain analgesia for the duration of labour using…
- Conditions
- Labor Pain, Obstetric Pain, Analgesia
- Trial name
- PIEB (NCT06266767)
- Testing
- Levobupivacaine and Fentanyl
- Where
- Qatar
- Volunteers
- 136 people
- Sponsor
- Hamad Medical Corporation
Milk Expression, Breast
Exparel PK and Breast Milk Excretion
Investigate the pharmacokinetics of Liposomal Bupivacaine and its excretion in breast milk in patients undergoing TAP block after their scheduled C -section delivery
- Trial name
- NCT03526419
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Foot Surgery, Ankle Surgery
Liposomal Bupivacaine With Dexamethasone for Foot Surgery
This study aims to understand the ideal formulation to utilize in saphenous nerve and popliteal nerve blocks for foot and ankle procedures.
- Conditions
- Foot Surgery, Ankle Surgery, Post Operative Pain, Popliteal Nerve Block
- Trial name
- NCT06465992
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.75% Inj, Dexamethasone
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Knee
Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty
The purpose of this study is to determine quantitative and qualitative differences in post-operative pain relief for patients undergoing primary total knee arthroplasty (TKA) who receive administration of a newly approved, long…
- Trial name
- NCT02166632
- Testing
- Intracapsular Injection, Periarticular Injection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Broward Health
Inguinal Hernia Unilateral
Comparison of Quadro-Iliac Plane Block and Transversalis Fascia Plane Block for Open Inguinal Hernia Repair
This prospective observational cohort study aims to compare the postoperative analgesic effectiveness of the quadro-iliac plane block (QIPB) and transversalis fascia plane block (TFPB) in patients undergoing elective unilateral…
- Trial name
- NCT07864064
- Testing
- Quadro iliac Plane Block, Transversalis Fascia Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Vezirköprü State Hospital
Thoracic
Pharmacokinetics of Single-Dose Liposomal Bupivacaine in Surgeon Performed Intercostal Nerve Blocks
Post-surgery pain management is critical for ensuring timely patient recovery and minimizing complications. Part of the multimodal approach to managing severe acute pain in the days following surgeries is the use of nerve blocks.
- Trial name
- NCT03708198
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Pain Syndrome, Dizziness
Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery
Prevention of postoperative pain is essential for the recovery of esophageal surgery. Epidural analgesia is a traditional and standard perioperative pain management for these patients.
- Conditions
- Pain Syndrome, Dizziness, Vomiting, Itching
- Trial name
- NCT06704698
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Zhejiang Cancer Hospital
Pain, Postoperative, Hysterectomy
Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy
Perioperative multimodal analgesia, defined by the use of various analgesic medications targeting different drug receptors, provides adequate pain relief with minimal or no opiate consumption.
- Conditions
- Pain, Postoperative, Hysterectomy, Morphine, Anesthesia, Spinal
- Trial name
- SPIN_GYN (NCT05654363)
- Testing
- Administration of morphine by intrathecal route, Administration of morphine by intravenous route
- Where
- Italy
- Volunteers
- 670 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spinal Anesthesia
Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section
To test the safety of high dose spinal in elective CS after prolonged sitting position.
- Trial name
- NCT02937792
- Testing
- intrathecal 15 mg bupivacaine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Analgesia
Opioid Free Anesthesia for Laparoscopic Cholecystectomy
The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure.
- Trial name
- NCT06202664
- Testing
- Erector Spinae Block, Opioid Analgesic
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Postoperative Pain
QIPB in Inguinal Hernia
Inguinal hernia repair is one of the most commonly performed surgical procedures. It is generally performed under regional anesthesia techniques, such as local anesthesia, peripheral nerve blocks, or neuraxial anesthesia (spinal…
- Trial name
- NCT06862609
- Testing
- Quadro iliac plane block, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Konya City Hospital
Anesthesia, Postoperative Pain
RIB for Perioperative Analgesia in CIED Patients
Rhomboid intercostal plane block (RIB) has been described in the last decade. Various clinical applications have been found to provide hemithorax analgesia.
- Conditions
- Anesthesia, Postoperative Pain, Arrhythmias, Cardiac
- Trial name
- NCT06449599
- Testing
- ultrasound, parenteral local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University - Cerrahpasa
Spinal Anesthesia, Postoperative Pain Management
Intravenous Dexamethasone for Prolonging Sensory Block in Spinal Anesthesia
The goal of this clinical trial is to learn if intravenous dexamethasone can help prolong the effect of spinal anesthesia in adults having elective pelvic, urologic, or proctologic surgery.
- Conditions
- Spinal Anesthesia, Postoperative Pain Management, Dexamethasone, Pelvic Surgery
- Trial name
- NCT07088432
- Testing
- Dexamethasone
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Tunis University
Cervical Disc Prolapse
Effect of Superficial Cervical Plexus Block on the Postoperative Quality of Recovery
Pain and discomfort after anterior cervical spine surgery is difficult to quantify and quoted as moderate in severity, often needing oral opioid analgesics.
- Trial name
- QoR (NCT01662219)
- Testing
- Superficial cervical plexus block for experimental group
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Cystitis, Interstitial
DMSO Efficacy in IC/PBS Patients During and After Treatment
The purpose of this study is to examine the efficacy of dimethylsulphoxide (DMSO) cocktail in patients with interstitial cystitis during the treatment period (12 weeks) and after it (at 6 weeks, 3, 6 and 12 month).
- Trial name
- NCT01074567
- Testing
- DMSO cocktail
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Spinal Anesthesia, Hyperbaric Bupivacaine
Intrathecal Injection of Hyperbaric Bupivacaine Versus a Mixture of Hyperbaric and Isobaric Bupivacaine in Patients Undergoing Lower Abdominal Surgery
The aim of this study is to compare the effects of intrathecal injection of hyperbaric bupivacaine versus injection of hyperbaric and isobaric bupivacaine in patients undergoing lower abdominal surgery.
- Conditions
- Spinal Anesthesia, Hyperbaric Bupivacaine, Isobaric Bupivacaine, Lower Abdominal Surgery
- Trial name
- NCT06050044
- Testing
- Group A (hyperbaric bupivacaine), Group B (Mixture of Hyperbaric and Isobaric Bupivacaine)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Helwan University
Pain, Postoperative
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
The purpose of this study is to compare two medications currently injected intra-operatively to help decrease pain after surgery in patients undergoing a primary total hip replacement (THR).
- Trial name
- NCT03001453
- Testing
- Liposomal Bupivacaine, 0.25% Bupivacaine with epinephrine, Saline
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- American Hip Institute
Erector Spinae Plane Block
Nerve Block for Severe Abdominal Pain in the Emergency Department
Currently, the standard treatment of nonsurgical abdominal pain in the Emergency Department (ED) includes narcotic pain medication. This can be addictive and contributes to the current opioid epidemic.
- Trial name
- ESPB (NCT07826936)
- Testing
- Bupivacaine (erector spinae plane block)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Irvine
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