Clinical trials: Bupivacaine
Clavicle Fracture
Interscalene vs. Superficial Cervical Block vs. Combination for Analgesia After Clavicle Fracture
The optimal analgesic peripheral nerve block (or combinations thereof) are undefined for clavicle fractures, the most frequent fracture in the human population.
- Trial name
- NCT03094481
- Testing
- SCPB, ISB, SCPB + ISB
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid Use, Pain, Postoperative
Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery
Enhanced recovery pathways (ERPs) emphasize evidence-based, multimodal anesthetic and analgesic choices to minimize opioid consumption while providing adequate pain control after surgery.
- Trial name
- ESPB-Spine (NCT04156581)
- Testing
- Bupivacaine, Dexamethasone, Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hospital for Special Surgery, New York
Fracture; Rib, Multiple
Erector Spinae Plane Block Versus Thoracic Epidural Analgesia in Patients With Multiple Fracture Ribs
To assess the analgesic and respiratory effect of continuous Erector Spinae Plane block versus Thoracic Epidural in patients with multiple fracture ribs.
- Trial name
- NCT03853330
- Testing
- Ultrasound, Bupivacaine HCl Inj 0.25%, Bupivacaine Hydrochloride, 0.125%-0.9% Injectable Solution
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Assiut University
Postoperative Pain
Depomedrol for Genicular Nerve Block.
This study is designed to test the efficacy of adding Depomedrol a long-acting steroid to bupivacaine for relieving postoperative pain and reducing opioid requirements following total knee replacement surgery.
- Trial name
- NCT05893771
- Testing
- Methylprednisolone Injection, Bupivacaine Hcl 0.5% Inj_#2, normal saline
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Menoufia University
Pain, Postoperative
Glossopharyngeal Nerve Block in Pediatric Adenotonsillectomy Operations
Tonsilloadenoidectomy operations in pediatric patients cause local pain. Especially, in order to reduce the need for narcotic painkillers, to ensure patient compliance and well-being, and to provide better quality pain management…
- Trial name
- NCT07873307
- Testing
- Bupivacaine hydrogen chloride (HCl) %0.125 in 0,2 milliliter/kilogram (ml/kg)+ 0,2 milliliter/kilogram (ml/kg) injection, Bupivacaine hydrogen chloride (HCl) %0.25 in 0,2 milliliter/kilogram (ml/kg)+ 0,2 milliliter/kilogram (ml/kg) injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University
Postoperative Nausea and Vomiting
Effect of Superficial Cervical Plexus Block on Post Operative Nausea and Vomiting in Tympanomastoid Operations
post operative nausea and vomiting are very common after tympanomastoid operations, in this study we are investigating the effect of superficial cervical plexus block on the incidence and severity of those post operative…
- Trial name
- NCT05504551
- Testing
- ultrasound guided superficial cervical plexus block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cholecystitis, Cholecystitis, Acute
M-Tapa Block for Laparoscopic Cholesistectomy
Modified Perichondral Approach Thoracoabdominal Nerve (M-TAPA) block is a novel block that provides effective analgesia of the anterior and lateral thoracoabdominal walls during laparoscopic surgery, in which local anesthetic is…
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic
- Trial name
- NCT05179629
- Testing
- M TAPA block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Analgesia
Bilateral Rhomboid Intercostal Block for Perioperative Analgesia in Patients Undergoing Bilateral Reduction Mammoplasty
Bilateral reduction mammoplasty is one of the most commonly performed breast surgery. The Postoperative pain following it should be minimized.
- Trial name
- NCT06225895
- Testing
- general anesthesia, Erector spinae plane block, a rhomboid intercostal nerve block
- Where
- 2 sites in Egypt
- Volunteers
- 72 people
- Sponsor
- Zagazig University
Ultrasound Therapy; Complications
Ultrasound-Guided Versus Conventional Method for Caudal Block
Caudal epidural block has been widely used, especially in pediatric surgery, to supply intraoperative and postoperative analgesia by affecting the region between T10 and S5 dermatomes in surgeries below the umbilical level.
- Trial name
- NCT03427437
- Testing
- Bupivacaine, Adrenalin, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 275 people
- Sponsor
- Omer Karaca
Cancer Liver
Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery
Adequate pain control improves postoperative outcomes and is imperative for enhanced recovery after surgery (ERAS) . Open liver resection surgery is associated with intraoperative blood loss, hypotension, coagulopathy, pulmonary…
- Trial name
- NCT06621472
- Testing
- Retrolaminar block group, subcostal TAP technique, thoracic Epidural
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Analgesia, Surgery
U/S-guided Continuous Quadratus Lumborum Block III in Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is considered to be the first choice and a more conservative procedure than open stone surgery.
- Conditions
- Analgesia, Surgery, Renal Stone
- Trial name
- NCT04800302
- Testing
- Continous Quadratum Lumborum Block III, Single dose Quadratum Lumborum Block III, Intra-venous Morphine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Nazmy Edward Seif
Postoperative Pain
The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section
The primary endpoint of this study is to investigate the effect of adding nalbuphine to intrathecal morphine on quality of postoperative analgesia and Morphine related side effects post- cesarean delivery.
- Trial name
- NCT02716129
- Testing
- Morphine, Morphine plus Nalbuphine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Abdelrady S Ibrahim, MD
Malignant Female Reproductive System Neoplasm
Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies
This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy.
- Trial name
- NCT04258631
- Testing
- Hydromorphone, Laparotomy, Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mayo Clinic
Low Back Pain
A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome
This study is being done to determine whether cooled radiofrequency ablation (CRFA) on the medial branch nerves of the lumbar facet joint is effective for the treatment of low back pain.
- Trial name
- STU00097239 (NCT02478437)
- Testing
- Conventional radiofrequency ablation (RFA), Cooled Radiofrequency Ablation (CRFA)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Northwestern University
Postoperative Pain, Analgesia
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy
Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure…
- Conditions
- Postoperative Pain, Analgesia, Supratentorial Brain Tumor
- Trial name
- NCT06406829
- Testing
- Dexmedetomidine, Normal saline, Local analgesic techniques
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Regional Anesthesia, Postoperative Pain
US-guided Pericapsular Nerve Group (PENG) Block in Different Volumes on Postoperative Pain in Hip Replacement Surgeries
Postoperative pain management has an important place in anesthesia practices. In order to ensure patient comfort after the surgery, to start postoperative rehabilitation early, and to prevent the process from causing mood…
- Conditions
- Regional Anesthesia, Postoperative Pain, Hip Surgery
- Trial name
- NCT06166602
- Testing
- PENG block with 0.25% bupivacaine.
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
External Oblique Intercostal Plane Block, Subcostal Transverse Abdominis Plane Block
Comparison of the Effects of External Oblique Intercostal Plane Block, Subcostal Transverse Abdominis Plane Block, and Their Combination in the Management of Postoperative Pain in Laparoscopic Cholecystectomy Surgery
This study aims to compare the efficacy of Subcostal Transversus Abdominis Plan Block, External Oblique Intercostal Plan Block and the combination of these two blocks, which are used in anesthesiology practice for postoperative…
- Trial name
- NCT07179731
- Testing
- subcostal transversus abdominis plane block, External Oblique Intercostal Plane Block, external oblique intercostal plane block and subcostal transversus abdominis plane block combination
- Volunteers
- 105 people
- Sponsor
- Istanbul Medeniyet University
Treatment Resistant Depression, Major Depressive Disorder
Stellate Ganglion Block for Major Depressive Disorder.
This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB).
- Trial name
- NCT04727229
- Testing
- Bupivacaine Hydrochloride, Normal Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Pain, Obstetric
Efficacy of Extended-Release Liposomal Bupivacaine for Post-Partum Pain Management Following Obstetrical Laceration
We propose a prospective, randomized, single blinded trial with subjects recruited from the WRNMMC Labor and Delivery Unit to study post-partum efficacy of Exparel® for pain control in patients undergoing a vaginal delivery who…
- Trial name
- NCT03152877
- Testing
- Bupivacaine Liposome Injectable Product, 0.25% plain bupivacaine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Chronic Plantar Fasciitis
Corticosteroid Injection, Extracorporeal Shock Wave Therapy, and Radiofrequency Ablation for Chronic Plantar Fasciitis:
Chronic plantar fasciitis is a prevalent condition causing persistent heel pain, often refractory to conservative treatments. This prospective randomized controlled trial aimed to compare the effectiveness of corticosteroid…
- Trial name
- NCT06737445
- Testing
- Radiofrequency ablation alone, Cortisone Injection, Extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Kars Harakani State Hospital
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